MASSIMILIANO RENZI

Curriculum Vitae
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Surname Renzi
Forename(s) Massimiliano

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Education

Ph.D. Neurophysiology - neural basis of cognitive functions 2004
Sapienza University of Roma (Italy)
Thesis published on Neuropharmacology (2004, 46: 727)

B.Sc. (Italian Laurea, 110 / 110 cum laude) 1998
Sapienza University of Roma (Italy)
Thesis published on Journal of Physiology (1999, 519: 723)
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Positions

Mar 2021-
Associate Professor BIO/09 PHYSIOLOGY
Settore concorsuale 05/D1
Department of Physiology and Pharmacology
Sapienza University of Roma

2014
Abilitazione Scientifica Nazionale
Associate Professor
Settore concorsuale 05/D1 – FISIOLOGIA

Dec 2011 –
Assistant Professor (Professore aggregato) BIO/09 PHYSIOLOGY
Department of Physiology and Pharmacology
Sapienza University of Roma

Nov 2003 – Nov 2011
Postdoctoral Research Fellow
Department of Neuroscience, Physiology and Pharmacology
University College London

Oct 1999 – Oct 2003
Ph.D. student (Neurophysiology)
Lab of Biophysics
Department of Human Physiology and Pharmacology
Sapienza University of Roma

Jun 1999 – Sept 1999 and
Nov 1998 – Dec 1998
Research Assistant
Lab of Physio-Pathology
Istituto Superiore di Sanità Roma (Italy)

Teaching
National
Sapienza University of Roma
Faculty of Farmacia e Medicina; Medicina e Odontoiatria; Medicina e Psicologia

1022410 and 10620819 - 14519-LM BIOTECNOLOGIE FARMACEUTICHE (active) (Human Physiology)
AAF1595 - 14519-LM BIOTECNOLOGIE FARMACEUTICHE (active)
1049378 - 28614-LT NURSING (active) (Human Physiology)

1034952 - 16006-LT INFERMIERISTICA P (ended)
1034830 - 16017-LT FISIOTERAPIA L (ended)

International teaching
Patch-clamp recording in brain slices for
‘Microelectrode Techniques for Cell Physiology’ MBA, Plymouth UK
‘Synaptic Pharmacology’ (3rd Year, BSc UCL PHAR3011)
‘Neuropharmacology’ (3rd Year, BSc UCL PHAR3001)
''Master in Neuroscience ' (UCL)
Supervision of research projects (undergraduate and master students)

Internationalization
2024 - present Promoter for:
Erasmus Learning Agreement between Sapienza – Pharmaceutical Biotechnology LM and Karolinska Institutet – Master’s Programme in Translational Physiology and Pharmacology

Research
Patch-clamp studies of neurophysiological alterations in Alzheimer Disease
Patch-clamp studies of GABAA, AMPA and NMDA receptors in native neuron-neuron and neuron-glia signalling
Patch-clamp studies of biophysical and pharmacological properties of LGICs in primary cell cultures and expression systems
Patch-clamp characterization of cells in culture on nano-engineered substrate (graphene; silicon nano-wires)

Collaboratori attuali
Prof M Migliore / Prof R Migliore - CNR IBFc (Palermo)
Prof R Ventura - Univ. Sapienza Dip.Psicologia (Roma)
Dr MT Viscomi - Univ. Cattolica (Roma)

Collaboratori precedenti
Prof. Stuart Cull-Candy & Prof. Mark Farrant - Dept Neurology, Physiology and Pharmacology – UCL, UK
Prof Patrick Anderson - Dept Cell and Developmental Biology– UCL, UK
Dr Abraham Acevedo-Arozena - MRC Mammalian Genetics Unit Harwell, UK
Dr Antonina Monaco - Dept of Biomedical Sciences, University of Antwerp, B
Prof Marcello D'Amelio - Campus Biomedico
Prof F Palma - Sapienza SBAI

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Funding
2024
Progetti Ricerca Ateneo (prog. Dipartimentale)
€3K

2023
Progetti Ricerca Ateneo
€3K

2022-2025
PNRR-IR Ebrains-Italy
€135K

2021
Progetti Ricerca Ateneo
€3K

Mar 2013 – Jun 2014
AriSLA - Pilot Grant 2012
€58K

Dec 2011 – Feb 2012
UCL Graduate School - Research Staff Bridging Fund
£12K

Dec 2008 – Nov 2010
Pasteur Institute – Fondazione Cenci-Bolognetti
Postdoctoral Research Fellowship
€36K

Apr 2004 – Mar 2006
Pasteur Institute – Fondazione Cenci-Bolognetti
Postdoctoral Research Fellowship
€45K

Nov 1999 – Oct 2003
M.I.U.R. – Department of Human Physiology and Pharmacology, Sapienza University of Roma
PhD Studentship
€38K
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Peer reviewing

2005 –
ad hoc referee (alone or jointly) for:
Nature
Nature Neuroscience
Journal of Neuroscience
Journal of Physiology
European Journal of Neuroscience
Cerebellum
Neuroscience
Human Molecular Genetics

2010 – 2013
Associate Faculty Member of Faculty 1000 - Biology
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Additional Qualifications and Training
2013
Autorizzazione Protocollo Sperimentale ‘in deroga’ per impiego di animali modello SLA (Ministero della Salute)

2013
Autorizzazione Protocollo Sperimentale ‘in comunicazione’ per impiego di animali modello SLA (Ministero della Salute)

2004
Personal Licence UK, Animals (Scientific Procedures) Act 1986 - Module 1-3 training
Institute of Biology, Biological Services, UCL

2000
Italian Chartered Biologist – marks 150 / 150 (Abilitazione professionale)

1996 – 1999
Pre- and Post-lauream experimental training (tirocinio)
Laboratory of Physio-Pathology
Istituto Superiore di Sanità, Roma (Italy)
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Publication record

Mancini et al. (2024)
Secure attachment to caregiver prevents adult depressive symptoms in a sex-dependent manner: A translational study
iSCIENCE
DOI: 10.1016/j.isci.2024.111328

Garofalo et al. (2023)
Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine
NATURE COMMUNICATIONS
DOI: 10.1038/s41467-023-38899-3

Colombo et al. (2023)
Rare Missense Variants of the Human β4 Subunit Alter Nicotinic α3β4 Receptor Plasma Membrane Localisation
MOLECULES
DOI: 10.3390/molecules28031247

Spoleti et al. (2022)
Early derailment of firing properties in CA1 pyramidal cells of the ventral hippocampus in an Alzheimer's disease mouse model
EXPERIMENTAL NEUROLOGY
DOI: 10.1016/j.expneurol.2021.113969

Gaetani et al. (2022)
Biocompatibility and Connectivity of Semiconductor Nanostructures for Cardiac Tissue Engineering Applications
BIOENGINEERING
DOI: 10.3390/bioengineering9110621

Pucci et al. (2021)
Evidence of a dual mechanism of action underlying the anti-proliferative and cytotoxic effects of ammonium-alkyloxy-stilbene-based α7- and α9-nicotinic ligands on glioblastoma cells
PHARMACOLOGICAL RESEARCH
DOI: 10.1016/j.phrs.2021.105959

Basilico et al. (2021)
Microglia control glutamatergic synapses in the adult mouse hippocampus
GLIA
DOI: 10.1002/glia.24101

D'Addario et al. (2021)
Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA dopaminergic neurons
NEUROBIOLOGY OF STRESS, 14:100324
DOI: 10.1016/j.ynstr.2021.100324

Bavo et al. (2020)
Modifications at C(5) of 2‐(2-Pyrrolidinyl)-Substituted 1,4- Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype
J. MED. CHEM., 63, 15668−15692
DOI: 10.1021/acs.jmedchem.0c01150

Piedimonte et al. (2020)
Silicon Nanowires as Contact Between the Cell Membrane and CMOS Circuits
Lecture Notes in Electrical Engineering ISBN:978-3-030-37276-7.... - ISSN:1876-1100
DOI: 10.1007/978-3-030-37277-4_28

Piedimonte et al. (2019)
Biocompatibility of Silicon NanoWires: a Step Towards IC Detectors
AIP Congress Proceeding 2145(1):020011
DOI: 10.1063/1.5123572

Piedimonte et al. (2019)
Silicon nanowires as biocompatible electronics-biology interface
IEEE
DOI: 10.1109/TRANSDUCERS.2019.8808824

Piedimonte et al. (2019)
Silicon nanowires to detect electric signals from living cells
MATER. RES. EXPRESS 6 084005
DOI: https://doi.org/10.1088/2053-1591/ab20f8

Onorato et al. (2016)
Noise Enhances Action Potential Generation in Mouse Sensory Neurons via Stochastic Resonance
PLOS ONE 11(8)e0160950
DOI: 10.1371/journal.pone.0160950

Coombs et al. (2012)
Cornichons modify channel properties of recombinant and glial AMPA receptors.
J NEUROSCIENCE, 32 (29):9796–9804
DOI: 10.1523/JNEUROSCI.0345-12.2012

Eyre et al. (2012)
Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor delta subunit isoforms
J NEUROSCIENCE, 32 (17):5853–5867
DOI: https://doi.org/10.1523/JNEUROSCI.6495-11.2012

Zonouzi et al. (2011)
Bidirectional regulation of calcium-permeable AMPA receptors in oligodendrocytes lineage cells
NATURE NEUROSCIENCE, 14 (11):1430–1438
DOI: 10.1038/nn.2942

Bright et al. (2011)
Profound desensitization by ambient GABA limits activation of -containing GABAA receptors during spillover
J NEUROSCIENCE, 31 (2):753–763
DOI: https://doi.org/10.1523/JNEUROSCI.2996-10.2011

Wulff et al. (2009)
Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning
NATURE NEUROSCIENCE, 12 (8):1042–1049
DOI: https://doi.org/10.1038/nn.2348

Soto et al. (2009)
Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5
NATURE NEUROSCIENCE, 12 (3):277–285
DOI: https://doi.org/10.1038/nn.2266

Renzi et al. (2007)
Climbing-fibre activation of NMDA receptors in Purkinje cells of adult mice
J PHYSIOL, 585 (1):91–101
DOI: 10.1113/jphysiol.2007.141531

Wulff et al. (2007)
From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors
NATURE NEUROSCIENCE 10 (7):923–929
DOI: https://doi.org/10.1038/nn1927

Fucile et al. (2004)
Nicotinic cholinergic stimulation promotes survival and reduces motility of cultured rat cerebellar granule cells
NEUROSCIENCE, 127 (1):53–61
DOI: 10.1016/j.neuroscience.2004.04.017

Tonini et al. (2004)
Unliganded human mutant α7 nicotinic receptors are modulated by Ca2+ and trace levels of Zn2+
NEUROPHARMACOLOGY 6 (5):727–733
DOI: 10.1016/j.neuropharm.2003.11.001

Fucile et al. (2003)
Fractional Ca2+ current through human neuronal 7 nicotinic acetylcholine receptors
CELL CALCIUM 34 (2):205–209
DOI: 10.1016/s0143-4160(03)00071-x

Palma et al. (2003)
Microtransplantation of membranes from cultured cells to Xenopus oocytes: a method to study neurotransmitter receptors embedded in native lipids
P.N.A.S., 100 (5):2896–2900
DOI: https://doi.org/10.1073/pnas.0438006100

Lax et al. (2002)
Chemokine receptor CXCR2 regulates the functional properties of AMPA-type glutamate receptor GluR1 in HEK cells
J NEUROIMMUNOL, 129 (1-2):66–73
DOI: 10.1016/s0165-5728(02)00178-9

Ragozzino et al. (2002)
Stimulation of chemokine CXC receptor 4 induces synaptic depression of evoked parallel fibers inputs onto Purkinje neurons in mouse cerebellum
J NEUROIMMUNOL, 127 (1-2):30–36
DOI: 10.1016/s0165-5728(02)00093-0

Visentin et al. (2001)
Altered outward-rectifying K+ current reveals microglial activation induced by HIV-1 Tat protein
GLIA 33, (3):181-190
DOI: 10.1002/1098-1136(200103)33:3<181::aid-glia1017>3.0.co;2-q

Visentin et al. (1999)
Two different ionotropic receptors are activated by ATP in rat microglia
J PHYSIOL, 519 (3):723–736
DOI: 10.1111/j.1469-7793.1999.0723n.x