MARIANNA MARANGHI

Curriculum Vitae

Personal information
First name(s) / Surname(s) Marianna Maranghi
Address(es) 155 Viale del Policlinico, 00166, Rome, Italy.
Telephone(s) Mobile: +39 392 9091560
E-mail marianna.maranghi@uniroma1.it ; mariannamaranghi@yahoo.it

Nationality Italian

Date of birth 08/02/1976

Gender Female

Desired employment / Occupational field: Assistant Professor in Internal Medicine at Sapienza University of Rome

Work experience:
Dates From March 2010 to May 2011
Occupation or position held Post doctoral Research position at Sapienza University Rome
Main activities and responsibilities Coordination of the clinical outpatient activities and of cardiovascular non-invasive diagnostics in type 2 diabetes
Name and address of employer Outpatients department for Diabetes and Endocrinology,Internal Medicine and Medical Specialties Department Policlinico Umberto I Hospital – Sapienza University, Rome

Type of business or sector University hospital
Dates From January 2009 to February 2010
Occupation or position held Post-doctoral Research Fellow at the Department of Internal Medicine- University of Helsinki Biomedicum- working on a project entitled ”Diabetic dyslipidemia and metabolic control” under the supervision of Professor Marjia Riitta Taskinen
Main activities and responsibilities Researcher
Name and address of employer Professor M.R. Taskinen
Type of business or Sector: Internal Medicine
Dates From February 2007 to December 2009
Occupation or position held Medical director, grade 1
Main activities and responsibilities Coordination of the Cardiovascular Prevention Clinic Policlinico Umberto I Rome
Name and address of employer Department of Clinical Science - Policlinico Umberto I Hospital– Sapienza University, Rome

Degrees
Title of qualification awarded 2011

Master degree in Diabetology
Name and type of organisation providing education and training Sapienza University , Rome

Dates 2005-2008
Title of qualification awarded Ph.D. Degree in Biomedical Technologies and Clinical Medicine
Sapienza University , Rome
Dates 2008
Title of qualification awarded NLA Master in Lipidology Advanced Training and Board Review Course
National Lipid Association

Dates 2000 – 2005
Title of qualification awarded Board in Internal Medicine
Sapienza University , Rome

Dates 1994 - 2000
Title of qualification awarded Master Degree in Medicine and Surgery
Sapienza University, Rome

Dates 1989 – 1994
Title of qualification awarded High School Leaving Qualification with specialization in Classical studies
Liceo Ginnasio Statale Dante Alighieri di Roma

Awards and Honors

Umberto Di Mario Foundation” Prize.2005
Marcello Santoro Prize, SISA Foundation 2012

Membership of Scientific-Professional Societies:
Endocrine Society (USA)
National Lipid Association (USA)
Italian society for the study of atherosclerosis
European Atherosclerosis Society

Teaching activities:
Internal Medicine
“B“ Course of Medicine Sapienza University
Scientific metodology VI
"A" course of Medicina Sapienza University

Internal Medicine in Geriatrics
Undergraduate Physiotheraphy Course
S. Giovanni Addolorata
Sapienza University

Mother tongue(s) Italian
Other language(s) English

Computer skills and competences Good working knowledge of the Internet and e-mail tools, as well as of the Office Package both in Windows and Mac OS, mainly used for the following purposes: to draft scientific articles and documentation; to process statistical data with Excel sheets and SPSS software and to create presentations for conferences and academic lessons.

Driving licence B
Volontary work and additional experience
2011 Good and clinical practice (GCP) course
2001 Three months voluntary fellow at the Laboratory of the Department of Clinical Pharmacology – Trinity College Dublin under the supervision of Professor D. Fitzgerald.
 2006 One month voluntary clinical working experience at the Center for Human Nutrition – The University of Texas, Southwestern Medical Center (Dallas, USA) under the supervision of Professor N. Abate.
 Sailing instructor at Centro Velico Caprera Sailing School Italy

Scientific Pubblications 
1. Maranghi M, Carnovale A, Durante C, Tarquini G, Tiseo G, Filetti S.Pharmacokinetics, pharmacodynamics and clinical efficacy of dapagliflozin for the treatment of type 2 diabetes.
Expert Opin Drug Metab Toxicol. 2015 Jan;11(1):125-37. doi: 10.1517/17425255.2015.986457. Epub 2014 Nov 24.

2. Barbarossa G, Renzi A, D'Erasmo L, Gallo A, Grieco E, Rossetti M, Carnovale A, Santilli M, Mandosi E, Coletta P, Pergolini D, Morano S, Maranghi M. The relation between glycemic control and HDL-C in type 2 diabetes: a preliminary step forward? Diabetes Res Clin Pract. 2014 Jan 8. pii: S0168-8227(14)00022-9. doi: 10.1016/j.diabres.2013.12.061.

3. Minicocci I, Santini S, Cantisani V, Stitziel N, Kathiresan S, Arroyo JA, Martí G, Pisciotta L, Noto D, Cefalù AB, Maranghi M, Labbadia G, Pigna G, Pannozzo F, Ceci F, Ciociola E,Bertolini S, Calandra S, Tarugi P, Averna M, Arca M. Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis. J Lipid Res. 2013 Dec;54(12):3481-90.

4. Arca M, Minicocci I, Maranghi M. The angiopoietin-like protein 3: a hepatokine with expanding role in metabolism. Curr Opin Lipidol. 2013 Aug;24(4):313-20

5. Robciuc MR*, Maranghi M*, Lahikainen A, Rader D, Bensadoun A, Oorni K, Metso J, Minicocci I, Montali A, Ciociola E, Ceci F, Arca M, Ehnholm C, Jauhiainen M. Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity and decreased serum free fatty acids . Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1706-13

6. Minicocci I, Cantisani V, Poggiogalle E, Favari E, Zimetti F, Montali A, Labbadia G, Pigna G, Pannozzo F, Zannella A, Ceci F, Ciociola E, Santini S, Maranghi M. Vestri AR, Ricci P, Bernin F, Arca M. Functional and morphological vascular changes in subjects with familial combined hypolipidemia: an exploratory analysis. Int J Cardiol. 2013 Oct 9;168(4):4375-8

7. Kaye SM, Maranghi M, Bogl LH, Kaprio J, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Taskinen MR, Pietiläinen KH.Acquired liver fat is a key determinant of serum lipid alterations in healthy monozygotic twins.Obesity (Silver Spring). 2012 Dec 12.

8. Coletta P., Barbarossa G., Pergolini D., D'Erasmo L, Renzi A., Mercuri L., Anatra M. G., Ciociola E, Verrienti A, Maranghi M Genetic determinants and early carotid atherosclerosis: is there a role for the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP-1) K121Q polymorphism? Preliminary results in non diabetic individuals. Endocrine. 2012 Dec;42(3):749-51.

9. Maranghi M, Prudente S, D'Erasmo L, Morini E, Ciociola E, Coletta P, Verrienti A, Arciello S, Copetti M, Pellegrini F, Santini SA, Morano S, Filetti S, Trischitta V.The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals. Nutr Metab Cardiovasc Dis. 2012 Mar 6.

10. Yetukuri L, Huopaniemi I, Koivuniemi A, Maranghi M, Hiukka A, Nygren H, Kaski S, Taskinen MR, Vattulainen I, Jauhiainen M, Orešič M. High density lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy. PLoS One. 2011;6(8):e23589. Epub 2011 Aug 24.

11. Bogl LH, Maranghi M, Rissanen A, Kaprio J, Taskinen MR, Pietiläinen KH. Dietary omega-3 polyunsaturated fatty acid intake is related to a protective high-density lipoprotein subspecies profile independent of genetic effects: a monozygotic twin pair study. Atherosclerosis. 2011 Dec;219(2):880-6.

12. Maranghi M, Hiukka A, Badeau R, Sundvall J, Jauhiainen M, Taskinen MR. Macrophage cholesterol efflux to plasma and HDL in subjects with low and high homocysteine levels: A FIELD substudy. Atherosclerosis. 2011 Nov;219(1):259-65.

13. Mastroianno S, Torlontano M, Scillitani A, D'Aloiso L, Verrienti A, Bonfitto N, De Bonis A, D'Agruma L, Muscarella LA, Guarnieri V, Dicembrino F, Maranghi M, Durante C, Filetti S. Coexistence of multiple endocrine neoplasia type 1 and type 2 in a large Italian family. Endocrine. 2011 Dec;40(3):481-5.

14. Durante C, Tallini G, Puxeddu E, Sponziello M, Moretti S, Ligorio C, Cavaliere A, Rhoden KJ, Verrienti A, Maranghi M, Giacomelli L, Russo D, Filetti S. BRAF V600E mutation and expression of proangiogenic molecular markers in papillary thyroid carcinomas. Eur J Endocrinol. 2011 Sep;165(3):455-63.

15. Irace C, Rossetti M, Carallo C, Morano S, Vespertini V, Mandosi E, Maranghi M, Fiorentino R, Filetti S, Gnasso A. Transaminase levels in the upper normal range are associated with oral hypoglycemic drug therapy failure in patients with type 2 diabetes. Acta Diabetol. 2011 Feb 9.

16. Colotto M, Maranghi M, Durante C, Rossetti M, Renzi A, Anatra MG. PFAPA syndrome in a young adult with a history of tonsillectomy. Intern Med. 2011;50(3):223-5. Epub 2011 Feb 1.

17. Sponziello ML, Bruno R, Durante C, D'Agostino M, Corradino R, Giannasio P, Ciociola E, Ferretti E, Maranghi M, Verrienti A, De Toma G, Filetti S, Russo D. Growth factor receptors gene expression and Akt phosphorylation in benign human thyroid nodules are unaffected by chronic thyrotropin suppression. Horm Metab Res. 2011 Jan;43(1):22-5.

18. Hiukka A, Maranghi M, Matikainen N, Taskinen MR. PPARalpha: an emerging therapeutic target in diabetic microvascular damage.Nat Rev Endocrinol. 2010 Aug;6(8):454-63. Epub 2010 Jun 22. Review. Erratum in: Nat Rev Endocrinol. 2010 Sep;6(9):476.

19. Castellone MD, Verrienti A, Magendra Rao D, Sponziello M, Fabbro D, Muthu M, Durante C, Maranghi M, Damante G, Pizzolitto S, Costante G, Russo D, Santoro M, Filetti S. A novel de novo germ-line V292M mutation in the extracellular region of RET in a patient with phaeochromocytoma and medullary thyroid carcinoma: functional characterization. Clin Endocrinol (Oxf). 2010 Oct;73(4):529-34.

20. Maranghi M, Pugliese F, Cianci R, Colotto M, Durante C, Anatra MG, Coletta P, Mercuri S, Rossetti M, Morano S, Filetti S. Atherosclerosis renal artery stenosis and in-stent restenosis in a diabetic patient: Targeting on diabetic dyslipidemia is a key intervention.J Endocrinol Invest. 2010 Apr;33(4):284-5.

21. Sponziello M, Scipioni A, Durante C, Verrienti A, Maranghi M, Giacomelli L, Ferretti E, Celano M, Filetti S, Russo D. Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines. J Endocrinol Invest. 2010 Jan;33(1):2-6.

22. Gatti A, Maranghi M, Bacci S, Carallo C, Gnasso A, Mandosi E, Fallarino M, Morano S, Trischitta V, Filetti S.Poor glycemic control is an independent risk factor for low HDL cholesterol in patients with type 2 diabetes. Diabetes Care. 2009 Aug;32(8):1550-2.

23. Costante G, Meringolo D, Durante C, Bianchi D, Nocera M, Tumino S, Crocetti U, Attard M, Maranghi M, Torlontano M, Filetti S. Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. J Clin Endocrinol Metab. 2007, 92(2): 450-5.

24. Ronga G, Bruno R, Puxeddu E, Calcinaro F, Montesano T, Travascio L, Colandrea M, Durante C, Maranghi M, Filetti S, Russo D. Radioiodine uptake in non-lactating mammary glands: evidence for a causative role of hyperprolactinemia. Thyroid. 2007, 17(4): 363-6.

25. Montesano T, Durante C, Attard M, Crocetti U, Meringolo D, Bruno R, Tumino S, Al- Nahhas A, Rubello D, Colandrea M, Maranghi M, Travascio L, Ronga G, Torlontano M. Age influences TSH serum levels after withdrawal of l-thyroxine or rhTSH stimulation in patients affected by differentiated thyroid cancer. Biomedicine & Pharmacotherapy 2007, 61(8): 468-71 .

26. Maranghi M, Coletta P, Durante C, Pergolini D, Filetti S. Malattia cardiovascolare e sindrome metabolica: oggi e domani. Recenti Progressi in Medicina. 2006, 97 (12): 719-26.

27. Romagnoli E, Carnevale V, Calandra P, D'Erasmo E, De Geronimo S, Pepe J, Manfredi G, Maranghi M, Aliberti G, Minisola S. Impact of fractures on health care in a major university hospital in Rome. Aging Clin Exp Res. 2003, 15(6): 505-11.

28. Romagnoli E, Carnevale V, Nofroni I, D'Erasmo E, Paglia F, De Geronimo S, Pepe J, Raejntroph N, Maranghi M, Minisola S.: Quality of life in ambulatory postmenopausal women: the impact of reduced bone mineral density and subclinical vertebral fractures.
Osteoporos Int. 2004, 15(12): 975-80.

29. Filetti S, Durante C, Maranghi M. A genetic based disease management in inherited cancer syndromes: the multiple endrocrine neoplasia model. Supportive & Palliative Cancer Care. 2006, 2 (suppl. 2): 13-16.

30. Durante C, Romagnoli E, Maranghi M, D’Aloiso L, Minisola S, D’Erasmo E, Filetti S. Hyperparathyroidism in multiple endocrine neoplasia type IIA. Clinical Cases in Mineral and Bone Metabolism. 2006, 3 (2): 162-6.

31. Violi F, Loffredo L, Maranghi M. Effect of vitamins E and C on transplant-associated atherosclerosis. Lancet. 2002, 360 (9331): 486.

32. Iuliano L, Micheletta F, Maranghi M, Frati G, Diczfalusy U, Violi F Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. Arterioscler Thromb Vasc Biol. 2001, 21 (10): E34-7.

1.

I declare under full personal responsibility that the information contained in the present CV are true and accurate.

Rome, 14/april /2015