Catalogo dei Corsi di studio

Actual position: Associate Professor of Organic Chemistry
At Dipartimento di Chimica e tecnologia del farmaco

Education

University graduation 2001 Sapienza
Università di Roma Laurea (master s degree) in Pharmaceutical Chemistry and Technology

Post-graduate studies 2006 Sapienza
Università di Roma PhD in Pharmaceutical Sciences (Dottorato di ricerca in Scienze Farmaceutiche, XVIII Ciclo)

Teaching experience

Year Institution Lecture/Course

2015-present Sapienza
Università di Roma Chimica organica e chimica delle sostanze organiche naturali , canali A-D (9CFU) e P-Z (3CFU), degree course Scienze Farmaceutiche Applicate.
2005-present Sapienza
Università di Roma Metodi fisici in chimica organica-Modulo 1 84CFU) , master degree course Chimica e tecnologia del farmaco.

Research Activities

The research activity can be arranged in two main lines: i) synthesis of chromatographic supports for molecular recognition studies and ii) study of stability/instability of bioactive compounds mainly enantiomers. The first line focuses in the field of separation science and includes as corollary some studies of advanced methodologies in the analysis of chiral and bioactive molecules. The second line is related to stereochemistry and focused in the stability of atropoisomers. From last years, as consequence of interaction or fusion of two research lines, the research has been also dedicated to development of supported organocatalysts for heterogeneous batch and flow catalysis.
Fields of interest:
- synthesis of chromatographic supports for HPLC and UHPLC in order to investigate their recognition properties towards molecules of biological and pharmaceutical interest. (chiral brush-type and receptor-like selectors)
- study of stereochemical stability of bioactive compounds as potential new drugs or organocatalysts in asymmetric synthesis by HPLC and NMR. (off-column method, dynamic HPLC and dynamic NMR)
- development of solid supported catalyst based on silica or polymethacrylate media. (chiral amine as catalysts)

Scientific Production
More than 80 papers, 5 book chapters, 1 patent. H index: 25
Last two-year publications

72) S. Manetto, G. Mazzoccanti A. Ciogli C. Villani F. Gasparrini, Ultra-high performance separation of basic compounds on reversed-phase columns packed with fully/superficially porous silica and hybrid particles by using ultraviolet transparent hydrophobic cationic additives, J Sep Sci 2020;43:1653 1662.

73) L. Di Magno, F. Di Pastena, M. Puxeddu, G. La Regina, A. Coluccia, A. Ciogli, S. Manetto, M. Maroder, G. Canettieri, R. Silvestri, M. Nalli. Sulfonamide Inhibitors of Catenin Signaling as Anticancer Agents with Different Output on c MYC, ChemMedChem 2020, 15, 2264 2268.

74) Franzini, R. Pierini, M., Mazzanti, A., Iazzetti, A. Ciogli, A., Villani, C, Molecular recognition of the hplc whelk-o1 selector towards the conformational enantiomers of nevirapine and oxcarbazepine, International Journal of Molecular Sciences, 2021, 22, 1-14. DOI: 10.3390/ijms22010144

75) S. Aiello, L. Pagano, F. Ceccacci, B. Simonis, S Sennato, F. Bugli, C. Martini, R. Torelli, M. Sanguinetti, A. Ciogli, C Bombelli, G Mancini, Mannosyl, glucosyl or galactosyl liposomes to improve resveratrol efficacy against Methicillin Resistant Staphylococcus aureus biofilm, Colloids and Surfaces A: Physicochemical and Engineering Aspects 617 (2021) 126321

76) Rocchina Sabia, Alessia Ciogli, Marco Pierini, Roberta Franzini, Antonia Iazzetti, Claudio Villani, Chromatographic separation of the interconverting enantiomers of imidazo- and triazole-fused benzodiazepines, Journal of Chromatography A 1647 (2021) 462148

77) G. Leodori, M. I. De Bartolo, D. Belvisi, A. Ciogli, A. Fabbrini, M. Costanzo, S. Manetto, A. Conte, C. Villani, G. Fabbrini, A. Berardelli, Salivary caffeine in Parkinson s disease, Scientific Reports (2021) 11:9823 | https://doi.org/10.1038/s41598-021-89168-6.

78) G. Mazzoccanti, F. Gasparrini, A. Calcaterra, C. Villani, A. Ciogli, Separation Static vs. Dynamic Electrostatic Repulsion Reversed Phase Liquid Chromatography: Solutions for Pharmaceutical and
Biopharmaceutical Basic Compounds. Separations 2021, 8, 59.
https://doi.org/10.3390/separations8050059

79) Fabio Buonsenso; Sabrina Madio; Alessia Ciogli; Gabriella Siani; Marco Pierini, On-Column Quantification of Amino Functionalities Bonded to Solid Porous Matrices Packed within High Performance Liquid Chromatography Columns, Journal of Chromatography A 1651 (2021) 462284

80) Primary Amine Catalyzed Activation of Carbonyl Compounds: A Study on Reaction Pathways and Reactive Intermediates by Mass Spectrometry. Eur. J. Org.Chem. 2021, 1 9, doi.org/10.1002/ejoc.2021012722 with cover feature

82) Nowak, R.; Tumber, A.; Hendrix, E.; ANSARI, M. S. Z.; Sabatino, M.; Antonini, L.; Andrijes, R.; Salah, E.; Mautone, N.; Pellegrini, F.; Simelis, K.; Kawamura, A.; Johansson, C.; Passeri, D.; Pellicciari, R.; Ciogli, A.; Del Bufalo, D.; Ragno, R.; Coleman, M.; Trisciuoglio, D.; Mai, A.; Oppermann, U.; Schofield, C.; Rotili, D., First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53, J. Med. Chem. 2021, 64, 23, 17031 17050.