Ritratto di Giovanna.Serino@uniroma1.it

per gli studenti dei corsi di:


Genetica Molecolare (corso di Laurea Triennale Scienze Biologiche)

Biologia Molecolare (modulo all'interno del corso Biologia Molecolare e biotecnologie ricombinanti - Laurea Triennale Biotecnologie Agro-alimentari e industriali)

Il corso di Biotecnologie vegetali per l'agricoltura, la medicina e l'ambiente non verra' piu' erogato a partire dal 2023/2024 e sara' sostituito da Plant solutions for climate change (corso in inglese, Laurea Magistrale in Biotecnologie e Genomica per l'industria e l'ambiente)


i corsi per l'AA 2023-2024 inizieranno il 4 marzo. Si consiglia l 2024 . Si cinsiglia la presenza alle lezioni. Ulteriori informazioni sono disponibili sui siti moodle dei corsi (link a lato, sotto "materiali didattici").

Insegnamento Codice Anno Corso - Frequentare Bacheca
MOLECULAR GENETICS 1019209 2023/2024

General objectives:

After completing this course students will be able to describe:

-what is climate change is and what are its main effects on plants and on the environment

-how plants contribute to climate change

-how plant biotechnology can be used to reduce climate change


Specific objectives

1. Knowledge and understanding - Students will get acquainted with the with essential concepts in climate change and plant biotechnology. Using specific examples, they will also learn the technologies and experimental approaches used in plant biotechnology to reduce climate change as well as the most important and recent discoveries in this field 


2. Ability to apply knowledge and understanding - Students will acquire the ability to dissect and discuss current research being performed in plant biotechnology to face climate change

3. Critical and judgmental capacities- Students will learn to critically discuss and evaluate experimental results, as well as to infer possible ethical issues.

4. Ability to communicate - Students enrolled in the course will be encouraged to contribute to the class discussion by describing specific experiments. This will enhance communication skills and critical thinking.

5. Ability to continue study independently in the life - Students will acquire an understanding of plant biology and biotechnology in relation to climate change. These skills will accompany the students during the rest of their academic career.

Green Biotechnologies for agriculture health and environment 10592907 2022/2023
MOLECULAR GENETICS 1019209 2022/2023
Green Biotechnologies for agriculture health and environment 10592907 2021/2022
MOLECULAR GENETICS 1019209 2021/2022
Green Biotechnologies for agriculture health and environment 10592907 2020/2021
MOLECULAR GENETICS 1019209 2020/2021
Green Biotechnologies for agriculture health and environment 10592907 2019/2020
MOLECULAR GENETICS 1019209 2019/2020
MOLECULAR GENETICS 1019209 2018/2019
GENOMICS 1022925 2016/2017

la docente e' disponible in diversi giorni ed orari. contattare la docente per email per stabilire una data e orario preciso


Family name, First name: Serino, Giovanna
Researcher unique identifier (ORCID): orcid.org/ 0000-0001-8689-6132
- H-INDEX: 25


2002 PhD Molecular, Cellular and Developmental Biology, Yale University
1993 Laurea cum laude in Biological Sciences, Sapienza University, Rome, Italy


2007- present Associate professor, tenured, Sapienza University, Rome, Italy


2003-2007 Assistant professor, Sapienza University, Rome, Italy
2002-2003 Post-doctoral fellow, Sapienza University, Rome, Italy
1996-2002 Graduate student, Yale University, USA
1993-1996 Research associate, Sapienza University, Rome, Italy
1990-1993 Undergraduate, Sapienza University, Rome, Italy


2015 National Scientific Qualification at the level of Full Professor in Plant Physiology
2005 Short-Term Fellowship, Japanese Society for the Promotion of Science
2002-2004 Long Term Fellowship, European Molecular Biology Organization
2002 John Spangler Nicholas Prize for outstanding doctoral candidate in Biology, Yale University, USA
1996-1998 Joseph Cullman Fellowship for Excellence in Research, Yale University, USA
1995-1996 Fellowship, Pasteur Institute-Cenci Bolognetti Foundation, Rome, Italy
1993-1995 Fellowship, National Research Council, Rome, Italy


2017-2022 Scientific Secretary of the Italian Federation for the Life Sciences (FISV)
2014-2018 Management Committee Substitute for the COST Action Proteostasis
2011-present Associate scientist at the CNR (National Research Council), Italy
2009-present Member of the editorial board of the Journal of Integrative Plant Biology
2009-2013 Adjunct Curator in the Genomics Program, New York Botanical Garden, USA
2008-2015 Italian Coordinator for the Multinational Arabidopsis Steering Committee

o 2023 PRIN 2022 Research Grant, Italian Ministry of Research. LIDS, Light and drought signals integration driving development transitions in plants 70000 euros (P;unit leader)
2021 Research Grant, Lazio Innova, Regione Lazio, Italy. Top of the crops: interazioni tra luce e ormoni nel controllo dell apertura fiorale in specie modello e ortive, 150000 EUR, C
2020 Research Grant, Sapienza University. Molecular mechanisms controlling the trade-off between drought stress and growth in plants - RP120172B587077F, 3500 EUR
2012-2014 MAE-MOST Grant for Italy-Israel Joint Research, Italian Ministry of Foreign Affairs Regulation of autophagy by the CSN complex, a possible therapeutic target for neurodegeneration. 20000 EUR
2010 Research Grant, Sapienza University. Role of the COP9 signalosome in chromatin structure and transcription in plants and yeast 15000 EUR
2009 Research Grant, Sapienza University Structure, function and interactions of CSN6, an essential protein for plant and animal development. 1700 EUR
2008 Research Grant, Sapienza University Mapping the interaction surfaces in the ubiquitin-proteasome system. 19000 EUR
2007-2010 Italy- Japan Joint Project, Italian Ministry of Foreign Affairs. Fine mapping of interaction surfaces within components of the ubiquitin-mediated protein degradation pathway 30000 EUR
2007-2009 Italy- Japan Joint Project, JSPS- CNR. Transcriptional regulation in higher plants by COP9 signalosome. 19000 EUR
2003-2007 Grant for Returning Scientists from abroad, Italian Ministry of Research 56000 EUR.
2019 Research Grant, Sapienza University Conserved mechanisms for the epigenetic regulation of telomere maintenance. Coordinator Gianni Cenci, Sapienza University. 13500 EUR P
2018 Research Grant, Sapienza University. Coordinator: Sabrina Sabatini P
2017 Research Grant, Sapienza University Conserved mechanisms for the epigenetic regulation of telomere maintenance. Coordinator Gianni Cenci, Sapienza University. 40000 EUR P
2016 Research Grant, Sapienza University. Molecular mechanisms in developmental boundary formation. Coordinator Paolo Costantino, Sapienza University Total budget 15000 EUR P
2015 Research Grant, Sapienza University. To the root of organ growth: the control of root meristem activity in Arabidopsis. Coordinator Paolo Costantino, Sapienza University 28586 EUR P
2013-2015 Grant for Italy- Japan Joint Projects, Italian Ministry of Foreign Affairs. Common regulatory mechanisms at the basis of hypocotyl and stamen growth in Arabidopsis. Coordinator: Maura Cardarelli, CNR 60000 EUR UL
2011-2013 PRIN 2010-2011. To the root of organ growth: the control of root meristem activity in Arabidopsis.Coordinator Paolo Costantino, Sapienza University P
2011 Research Grant, Sapienza University. Post-translational regulation of seed germination and hypocotyl elongation. Coordinator: Paola Vittorioso, Sapienza University. Total budget 8000 EUR P
2009-2011 Research Grant, Pasteur Institute-Cenci Bolognetti Foundation, Rome, Italy. Role of the COP9 signalosome in transcription modulation and chromatin organization in yeast and plants. Coordinator: Rodolfo Negri, Sapienza University. 50000 EUR UL
2007-2010 ERA-NET Plant Genomics. Coordinator for Italy: Paolo Costantino, Sapienza University. Total budget 1788397 EUR P


- Reviewer for National Evaluation and Funding Agencies (VQR 2004-2010, 2010-2014, ANVUR, CIVR).
- Reviewer for International Funding Agencies (BSF, GIF, ESF, BARD)
- Reviewer/ rapporteur for the European Commission FP7 People and Horizon 2020 (ERC, ITN, IF), HORIZON EUROPE
- Panel member for FWO (2022-present)
- Reviewer for international journals (Journal of Experimental Botany, Plant Cell, Cell Reports, Plant Journal, Plos).
- Member of the editorial board of the Journal of Integrative Plant Biology (2009-2018).
- Member of the editorial board of the Journal Biomolecules (2019-present).
- Member of the editorial board of Frontiers in Plant Science (2022-present)
- See also my profile on Publons.


Since 2018 Member of the Italian Society for Biophysics and Molecular Biology (SIBBM, https://sibbm.org)
2017-2022 Scientific Secretary of the Italian Federation for the Life Sciences (FISV, www.fisv.org)
Since 2023 Member of the Italian Society for Agricultural genetics (SIGA,http://www.geneticagraria.it/home.asp)


2020 Member of the scientific committee of the international FISV symposium on SARS-CoV-2 Biology and COVID-19: Current research and perspectives (on line,16/09/2020)
2019 Member of the Scientific committee of the International Conference ZOMES X, Akko, Israel, 4-7/02/2019
2018 Member of the Organizing Scientific committee of the XV FISV congress, Sapienza Università di Roma, IT, 18-21/09/2018
2017 Main organizer of the Workshop The ubiquitin-proteasome system in yeast, plant and human. Hypotheses for new anti-cancer therapies , Sapienza University, Rome IT, 13/02/2017
2017 Main organizer of the International Conference ZOMES IX, Hotel Aran Mantegna, Rome, IT, 14-17/02/2017
2011 Co-organizer of the workshop Control of protein degradation in plant development and environmental
response , CNR, Rome, IT, 11/11/2011


The research in my lab aims at understanding how environmental factors affect the molecular mechanisms regulating plant development. More in detail, we are interested in understanding how and why light and drought affect the activity and protein stability of key developmental regulators. In the lab, we use Arabidopsis thaliana as a model system, because of its small size, fast life cycle, trim genome and easy genetics. We are currently pursuing two main research lines:

· Regulation of the ubiquitin proteasome pathway and its targets during plant development and in response to combined drought and light stress
We have recently discovered that the function of the major class of ubiquitin ligase enzymes (the enzymes that regulate the stability of many regulatory proteins) is differentially regulated during plant development, as well as in response to abiotic stress, such as drought. We are currently characterizing the physiological relevance and the cellular and molecular pathways responsible for this regulation.

· Regulation of flower organs development by light
While we have a very clear picture of how light regulates flowering time, very little is known on how light affect the growth of flower organs. We have found that light is able to regulate the growth of stamens (the male reproductive organs), using a signaling cascade that shared similarities with the one employed by light and temperature to regulate the growth of another organ, the hypocotyl; this suggests that the same signaling module has been recruited multiple times during evolution to translate environmental stimuli into distinct adaptational growth processes.


Prof. NIng Wei , School of Life Sciences, Southwest University, Chongqing 400715, China, on light regulated plant development

2023 Organization of the workshop on Symmetries and Asymmetries in Nature open to the general public, MACRO museum, Rome, IT
2020 Invited talk The COP9 signalosome regulates developmental phase transitions in Arabidopsis thaliana, 4th International and 16th Iranian Genetic Congress 2020 (GC2020) co-organized by SIBBM, 30/09-02/10/2020, online
2020 Invited seminar Molecular mechanisms of drought response in plants , PhD program in Evolutionary Biology and Ecology, Tor Vergata University, Rome, 06/07/2020, online
2019 Invited Seminar The ubiquitin proteasome pathway in the environmental control of plant growth and development to the PhD students in Molecular and Cellular Biology, Department of Biosciences, University of Milan, Milan, IT
2019 Invited Seminar Cullin Neddylation is regulated during plant development and response to abiotic stress", Scuola Superiore Sant Anna, Pisa, IT
2019 Participated to the Walking with Science Project (PLS- piano Lauree Scientifiche) by giving seminars and organizing classes projects on plant science with High School students from the Rome area (Liceo Cannizzaro).
2017-2020 Organization, coordination and promotion of the FISV days , an event that brings scientist and high school students together (https://www.fisv.org/25-fisv-days-1.html). Under my guidance the FISV days have grown from being hosted only by La Sapienza University to a National event with multiple locations from southern to northern Italy.

Holness S, Bechtold U, Mullineaux P, Serino G*, Vittorioso P* (2023) Highlight Induced Transcriptional Priming against a Subsequent Drought Stress in Arabidopsis thaliana. Int J Mol Sci. 2023 24:6608. IF 5.9 (* co-corresponding author).

Casagrande F, Serino G. (2023) Immunoprecipitation of Cullin-Ring Ligases (CRLs) in Arabidopsis thaliana Seedlings. Methods Mol Biol 2581:31-42

Casagrande, F., Xie, Q., Serino, G (2022). A useful toolbox for the detection of SCF E3 ligase activity. Molecular Plant15: 1654-1655. IF 13.2-

Linster E, Forero Ruiz FL, Miklankova P, Ruppert T, Mueller J, Armbruster A, Gong X, Serino G, Mann M, Hell R, Wirtz M (2022) Cotranslational N-degron masking by acetylation promotes proteome stability in plants. Nature Communications, 13:810.

Chen J, Jiang J, Liu J., Qian S, Song J, Kabara R, Delo I, Serino G, Liu F, Hua Z, Zhong X (2021). F-box protein CFK1 interacts with and degrades de novo DNA methyltransferase in Arabidopsis. New Phytol. 229:3303-3317

Marzi D, Brunetti P, Mele G, Calò L, Napoli N, Spaziani E, Matsui M, De Panfilis S, Costantino P, Serino G*, Cardarelli M*. (2020) Light controls stamen elongation via cryptochromes, phytochromes and COP1 through HY5 and HYH. Plant J. 103:379-394. (* co-corresponding author)

Napoli N, Ghelli R, Brunetti P, De Paolis A, Cecchetti V, Tsuge T, Serino G, Matsui M, Mele G, Rinaldi G, Palumbo A, Costantino P, Cardarelli M (2018). A newly identified flower-specific Splice variant of ARF8 regulates Arabidopsis stamen elongation and endothecium lignification. Plant Cell 30:620-637

Shu K, Chen Q, Wu Y, Liu R, Zhang H, Wang P, Li Y, Wang S, Tang S, Liu C, Yang W, Cao X, Serino G, Xie Q (2016). ABI4 mediates antagonistic effects of abscisic acid and gibberellins at transcript and protein levels. Plant J. 85:348-61.

Cirigliano A. Menta S, Mori M, Licursi V, Danovska S, Vapore v, Serino G, Pick E, Botta B, Negri R, Rinaldi T. (2015) S. cerevisiae as a tool to select inhibitors of the deneddylating activity of the COP9 signalosome. Yeast 32 S175-S175

Franciosini A, Moubayidin L, Du K, Matari NH, Boccaccini A, Butera S, Vittorioso P, Sabatini S, Jenik PD, Costantino P, Serino G (2015). The COP9 SIGNALOSOME is required for postembryonic meristem maintenance in Arabidopsis thaliana. Mol Plant 8:1623-34.

Tian M, Lou L, Liu L, Yu F, Zhao Q, Zhang H, Wu Y, Tang S, Xia R, Zhu B, Serino G, Xie Q (2015). The RING finger E3 ligase STRF1 is involved in membrane trafficking and modulates salt stress response in Arabidopsis thaliana. Plant J. 82:81-92.

Santopolo S, Boccaccini A, Lorrai R, Ruta V, Capauto D, Minutello E, Serino G, Costantino P, Vittorioso P (2015). DOF AFFECTING GERMINATION 2 is a positive regulator of light-mediated seed germination and is repressed by DOF AFFECTING GERMINATION 1. BMC Plant Biol. 15:72

Boccaccini A, Santopolo S, Capauto D, Lorrai R, Minutello E, Serino G, Costantino P, Vittorioso P (2014). The DOF protein DAG1 and the DELLA protein GAI cooperate in negatively regulating the AtGA3ox1 gene. Mol. Plant 7:1486-1489.

Licursi V, Salvi C, De Cesare V, Rinaldi T, Mattei B, Fabbri C, Serino G, Bramasole L, Zimbler J, Pick E, Barnes B, Bard M, Negri R (2014). The Cop9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in S. cerevisiae. FEBS J. 281:175-190.

Franciosini A, Lombardi B, Iafrate S, Pecce V, Mele G, Lupacchini L, Rinaldi G, Kondou Y, Gusmaroli G, Aki S, Tsuge T, Deng XW, Matsui M, Vittorioso P, Costantino P and Serino G (2013). The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation. Mol. Plant 6:1616-1629

Serino G, Pick E (2013). Duplication and familial promiscuity within the proteasome lid and COP9 signalosome kin complexes. Plant Sci. 203-204: 89-97.
Di Giacomo E, Serino G, Frugis G (2013). Emerging role of the ubiquitin proteasome system in the control of shoot apical meristem function. J. Integr. Plant Biol. 55:7-20.

Serino G, Xie Q (2013). The ever expanding role of ubiquitin and SUMO in plant biology. J. Integr. Plant Biol. 55: 5-6.

Kotiguda GG, Weinberg D, Dessau M, Salvi C, Serino G, Chamovitz DA, and Hirsch J (2012). The Organization of a CSN5-containing subcomplex of the COP9 Signalosome. J. Biol. Chem. 287:42031-42041.

De Cesare V, Di Maria V, Salvi C, Licursi V, Rinaldi T, Serino G, Balliano, G, Negri R (2011). Role of the COP9 signalosome in transcription modulation of genes involved in lipid metabolism and ergosterol biosynthesis in S.cerevisiae, FEBS J. 278:83-83

Wei N*, Serino G*, and Deng XW (2008). The COP9 signalosome: more than a protease. Trends in Biochemical Sciences 33:592-600 (* co-first authorship).
Gusmaroli G, Figueroa P, Serino G, and Deng XW (2007). Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Cullin3- based E3 ligases. Plant Cell 19: 564-581.

Cecchetti V, Altamura MM, Serino G, Pomponi M, Falasca G, Costantino P and Cardarelli M (2007). ROX1, a gene induced by rolB, is involved in procambial cell proliferation and xylem differentiation in tobacco stamen. Plant Journal 49: 27-37.

Figueroa P, Gusmaroli G, Serino G, Ma L, Shen Y, Feng S, Bostick M, Callis J, Hellmann H, Estelle M and Deng XW (2005). Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo. Plant Cell 17: 1180-1195.

Serino G, Deng XW (2003). The COP9 signalosome: regulating plant development through the control of proteolysis. Annu. Rev. Plant Biol. 54: 165-182.

Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, Deng XW (2003). Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell 15: 719-731.

Schwechheimer C, Serino G, Deng XW (2002). Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 function. Plant Cell 14:2553-2563.

Peng Z, Serino G and Deng XW (2001). Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted development processes in Arabidopsis. Plant Cell 13:2393-2407.

Peng Z, Serino G and Deng XW (2001). A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3. Development 128:4277-88.

Serino G*, Schwechheimer C*, Callis J, Crosby WL, Lyapina S, Deshaies RJ, Gray WM, Estelle M and Deng XW (2001). Interaction of the COP9 signalosome with the E3 ubiquitin ligase SCFTIR1 in mediating auxin-response. Science, 292:1379-1382 (* co-first authorship).

Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N and Deshaies RJ (2001). Promotion of NEDD8-CUL1 conjugate cleavage by COP9 signalosome. Science 292:1382-1385.

Peng Z, Staub JM, Serino G, Kwok SF, Kurepa J, Bruce BD, Vierstra R, Wei N and Deng XW (2001). The cellular level of PR500, a protein complex related to the19S Regulatory Particle of the proteasome, is regulated in response to stress in plants. Mol. Biol. Cell 12:383-392.

Serino G, Tsuge, T, Kwok SF, Matsui M, Wei N and Deng XW (1999). Arabidopsis cop8 and fus4 mutations define the same locus that encodes subunit 4 of the COP9 signalosome. Plant Cell 11:1967-1979.

Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M and Deng XW (1998). The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr. Biol. 8:919-922.

Bellincampi D, Cardarelli M, Zaghi D, Serino G, Salvi G, Gatz C, Cervone F, Altamura MM, Costantino P and De Lorenzo G. (1996). Oligogalacturonides prevent rhizogenesis in rolB transformed tobacco explants by inhibiting auxin-induced expression of the rolB gene. Plant Cell 8:477-487.

Serino G, Clerot D, Brevet J, Costantino P and Cardarelli M. (1994). Rol genes of Agrobacterium rhizogenes cucumopine strain: sequence, effects, and pattern of expression. Plant Mol Biol 26:415-422.
Serino G and Pick E (2021). NEDDylation and oxidative stress. In: Proteostasis and proteolysis, edited by Chondrogianni, Pick and Gioran, CRC Press, Taylor and Francis group
Serino G and Marzi D (2018) Arabidopsis thaliana as an experimental system. In: eLS., John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0002031.pub3]
Franciosini A, Serino G (2016). Immunoprecipitation of Cullin-RING Ligases (CRLs) in Arabidopsis thaliana Seedlings. Methods Mol Biol 1450:11-21
Franciosini A, Serino G, Deng XW (2014) Signaling: COP9 signalosome. In: Howell S.(Ed.) The Plant Sciences vol II (p. 313-332). Molecular Biology: Springer Reference (www.springerreference.com). Springer-Verlag Berlin Heidelberg
Serino G (2008). Protein synthesis (La sintesi proteica). In: Bozzaro S., Del Sal G., Ferrari S, Tripodi M. Biologia e Genetica. vol. 1 (p. 215-240). PADOVA: Piccin Nuova Libraria (Italy)
Serino G, Sabatini S, Costantino P (2006). Transgenic plants. In: G Melino, G Ciliberto. Argomenti di Biologia Molecolare. SEU, Società Editrice Universo (Italy)
Serino G and Deng XW (2002) Protein Coimmunoprecipitation . in Weigel, D., and Glazebrook, J. Arabidopsis-A Laboratory Manual (p. 233- 237). Cold Spring Harbor Laboratory Press, Cold Spring Harbor.