CELLULAR AND MOLECULAR PATHOLOGY

Course objectives

General Aims The objective of the course of Molecular and Cellular Pathology is to provide a firm foundation for understanding the molecular and cellular basis of disease. Goals: understanding the molecular complexity in human disease basis, understanding how most common diseases are linked to the dysfunction of specific pathways and how the application of molecular and cellular approach might help to advance medical research and the translation and application of knowledge to human disease. Specific Aims 1. Knowledge and Understanding The goal of the courses is to provide students a rigorous intellectual foundation of the cellular and molecular pathogenesis of human disease. Appreciate how most human diseases are linked with molecular or cellular dysfunction. Students should be able to articulate basic disease mechanisms that can underlie an identified pathology. 2. Applying Knowledge and Understanding At the end of the course students will have a solid understanding of the basic mechanisms at the cellular and molecular level that are correlated with the pathologic mechanisms that underlie human disease. This background is particularly important for Pharmaceutical Biotechnolgy students by equipping students with an advanced knowledge of molecular pathology and an understanding of the relevant principles and rationale for practical applications of therapeutic approach. 3. Making judgments Didactic and highly interactive lectures are provided to obtain an understanding of how in most common diseases insufficient knowledge about the pathogenesis of human diseases may limit the effectiveness of the present therapeutic approaches. Students will know how molecular and cellular pathology is presently applied to gain insight into how disease conditions are investigated at a molecular level, as well as understanding how this may positively affect the therapeutic approach to human diseases. 4. Communication skills Students' achievement of learning outcomes is demonstrated by the ability to analyze and critically discuss molecular and cellular mechanisms that contribute to human disease. Students’ evaluation is based by oral exam and the final score represents the sum of the two modules of the course. The overall knowledge of students is verified and students obtain their evaluation from grade 18 to grade 30. An exam is considered passed if the final grade is equal to or higher than 18/30. In the event of a full grade (30/30), the Examination Board may grant honours (lode). 5. Learning skills The Program in Molecular and cellular pathology focuses on the molecular mechanisms that cause diseases, the newest technologies in genomics, and proteomics as well as the development of prognostic, diagnostic and therapeutic tools. This is a crucial aspect to help students understand their learning interests as Pharmacological Biotechnology students, enhancing their dispositions to be active and autonomous learners.

Channel 1
CLAUDIO TALORA Lecturers' profile

Program - Frequency - Exams

Course program
Module 1: Model system in biomedical research. Multi-omics approachs to human diseases. Molecular Mechanism of Cell injury in human Diseases. Molecular Mechanism of oncogenesis and precision medicine. Inflammatory mechanisms: the molecular basis of inflammation: the molecular basis of inflammation. Mechanism Molecular basis of Diseases of the endocrine system. Nuclear Receptor: mechanisms of action and therapeutic targets. Molecular Basis of Pathogenesis of Diabetes. Molecular basis of hepatic pathologies. Module 2: Molecular mechanisms behind degenerative diseases of the heart, skeletal muscle, lungs, circulatory system, peripheral and central nervous system. New approaches in regenerative medicine, tissue engineering, drug delivery, generation of 3D tissue and organ on a chip for disease modeling.
Prerequisites
None. No specific requirement are needed to attend the course: However, a background knowledge of Biology and Genetics, Biochemistry, Histology and Embryology, Microbiology and Virology, Human Anatomy is expected.
Books
Pontieri-Russo-Frati, Patologia Generale, Ed Piccin Robbins and Cotran, Basi patologiche delle malattie, Elsevier Saunders Rubin and Strayer, Patologia Generale, Ed Piccin Thompson & Thompson Genetica in Medicina Robert L. Nussbaum MD FACP FACMG;Roderick R. McInnes CM MD PhD FRS(C) FCAHS FCCMG;Huntington F Willard PhD Thompson & Thompson Genetics in Medicine Robert L. Nussbaum MD FACP FACMG;Roderick R. McInnes CM MD PhD FRS(C) FCAHS FCCMG;Huntington F Willard PhD Material provided by the teacher: research and review articles Teaching material provided by the Instructor's course : Reviews and scientific article.
Teaching mode
Frontal lessons.
Exam mode
Verbal examination- evaluation include a discussion with the student of the topics covered in the classroom.
Lesson mode
Frontal lessons.
  • Lesson code1022409
  • Academic year2024/2025
  • CoursePharmaceutical Biotechnology
  • CurriculumSingle curriculum
  • Year2nd year
  • Semester1st semester
  • SSDMED/04
  • CFU6
  • Subject areaDiscipline biotecnologiche comuni