Biology

Programma dell’insegnamento ENG The course consists of 24 lessons of two hours each, for a total of 48 hours of lessons. The Professor can organize seminars held by external expert in the field of forensic genetics • History of forensic genetics. (4 h) • Human genetic diversity as a tool in forensic genetics. (6 h) • Population genetics basis of forensic inferences. (4 h) • Complex biological samples: Degraded DNA, mixtures, touch DNA. STR profile interpretation. (4 h) • Lineage markers: mtDNA, Y chromosome. (4 h) • X chromosome in forensic genetics. (2 h) • Disaster victim identification. Familial searching, Personal identification. (2 h) • Probability and statistical interpretation. Random match probability, exclusion probability, diversity indexes. (4 h) • Paternity test, paternity index. (4 h) • Phenotype and ancestry informative markers. (2 h) • Next generation sequencing applications. (2 h) • Non-human forensic genetics. (2 h) APPLIED FORENSIC GENETICS • Management of biological forensic samples. (3 h) • DNA extraction and quantitation. (3 h) • Genotyping methods. (3 h) • DNA databases in forensic genetics. (3 h)

The course requires knowledge of Mendelian genetics and population genetics, and basic knowledge of statistics and probability theory.

TAGLIABRACCI A. (2010) "INTRODUZIONE ALLA GENETICA FORENSE". SPRINGER-VERLAG ITALIA. BUTLER JM (2010) “FUNDAMENTALS OF FORENSIC DNA TYPING”. ELSEVIER

Classroom lessons are not mandatory but strongly recommended

The final evaluation consists of an oral examination on the course topics and includes the interpretation of a challenging DNA profile or forensic casework

Non previsto

The course will include both theoretical and applied lectures. Theoretical lectures will provide students with the tools to understand the main topics of forensic genetics. The applied lessons will cover the production and interpretation of genetic profiles and the calculation of various forensic indices. Students will also learn how to consult and use forensic genetics databases available online.