Cellular and molecular mechanisms of the immune response

Course objectives

General skills The aim of this course is to provide the student with a broad knowledge of the molecular and cellular mechanisms of immune responses. The course explores the molecular mechanisms that regulate the movement, activation, differentiation and metabolism of the effector cells of innate (phagocytes, antigen-presenting and natural killer cells) and adaptive immunity (T and B lymphocytes). The course includes lectures and classroom teaching sessions, with a description of the experimental techniques used today for the analysis of the functioning of the immune system and learning assessment activities through written exam simulation tests. Specific skills 1.Knowledge and understanding skills - Knowledge and understanding the nature and role of the molecules involved in the recognition of microbes - Knowledge of the main biochemical pathways and molecules involved in the regulation of both proliferative and effector responses, and in the death of the immune cells - Knowledge and understanding the molecular factors that regulate cellular metabolism and their function in the activation and contraction of the immune response 2. Ability to apply knowledge and understanding Be able to use the specific terminology of the discipline Be able to identify the right procedures to solve the questions of Molecular Immunology Apply the knowledge of the specific topics covered in class and the techniques used in Molecular Immunology 3. Making judgmental The student will learn to discuss and critically evaluate the progress achieved in the Molecular Immunology field and to ask questions for elaborating and deepening the knowledge learned 4. Ability to communicate what has been learned The student will be able to communicate what has been learned during the written exam 5. Ability to continue the study independently in the course of life The student will acquire not only basic knowledge, but also the methodologies and terminology specific to the field of Molecular Immunology. This knowledge will allow the student to continue his / her study independently, even after the end of the course and passing the exam. Prerequisiti: ITA Nonostante non siano richieste propedeuticità, lo studente deve possedere un'adeguata conoscenza della biologia cellulare e molecolare, della biochimica e della fisiologia.

Channel 1
MARIA TERESA FIORILLO Lecturers' profile

Program - Frequency - Exams

Course program
The course is aimed to provide the students with the basic knowledge to understand the cellular and molecular mechanisms regulating the motility, activation, differentiation and metabolism of the effector cells of both innate (phagocytic cells, antigen presenting cells, natural killer cells and lymphoid innate cells) and adaptive immunity (T and B lymphocytes). In particular: 1) The molecules and mechanisms regulating cytoskeleton reorganization events required for motility, adhesion, endocytosis and exocytosis. 2) The signal transduction cascades activated by membrane receptors and regulating cellular activation and differentiation. 3) The mechanisms regulating gene expression: transcription factors and their regulation. 4) The signaling cascades and molecules regulating cellular metabolism and their functions in activating and dampening immune responses. The topics described above will be covered during classroom teaching. The last 12 hours will be reserved for educational workshops with a description of the experimental techniques used for the analysis of the molecular mechanism of the immune response and evaluation of learning activities through written exam simulation tests. These tests will aim to evaluate the knowledge acquired by the student during the course. At the end of the course, the students will have acquired knowledge of the specific topics covered in the classroom, the ability to identify the links between the different parts of the course and the ability to manage the specific discipline language.
Prerequisites
Although no prerequisites are required, it is recommended that students have an adequate knowledge of cellular and molecular biology, biochemistry, and physiology.
Books
Abbas, Lichtman, Pillai. "Molecular and cellular immunology". Edra. IX Edition The student will be provided with teaching materials, articles and reviews on the topics covered during the lessons and uploaded to the Moodle platform.
Teaching mode
The educational format will be based on classroom sections of 2 hours each that will be primarily focused on the description of various aspect of the molecular mechanisms of immune response, followed by 12 hours of educational workshops, with a description of the experimental techniques used for the analysis of the molecular mechanisms of immune response and evaluation of learning activities through written exam simulation tests. These tests will be aimed to evaluate the knowledge acquired by the student.
Frequency
Attendance of the course though not mandatory is strongly recommended.
Exam mode
Assessment of learning outcomes will be done through a written exam at the end of the course, the exam will consist of directly-answer questions on the overall program. In the evaluation of the tests and in the assignment of the final mark, the following skills will be taken into account: the level of knowledge of the different topics (superficial, precise and complete, complete and in-depth), the ability to apply the theoretical concepts (discrete, good, well established), the capacity for analysis, synthesis and interdisciplinary links (sufficient, good, excellent), the critical ability and the formulation of judgments (sufficient, good, excellent).
Bibliography
The bibliography on the individual topics covered during the course will be indicated on the teaching page on E-learning platform.
Lesson mode
The course will be based on two-hour lectures (general concepts and in-depth analysis), focusing primarily on the description of the molecular and cellular mechanisms of the immune response and the experimental techniques currently used in basic research and diagnostics. Learning assessment activities will include exam simulations. These tests will assess the knowledge acquired by the student during the course.
  • Lesson code1047783
  • Academic year2025/2026
  • CourseBiology
  • CurriculumBiotecnologico cellulare
  • Year3rd year
  • Semester1st semester
  • SSDMED/04
  • CFU6