GENERAL PATHOLOGY
Course objectives
The course is aimed to guide the students through the understanding of how the disruption of the homeostatic balance both at cellular and systemic level can lead to the pathology. The students will receive the concepts necessary 1) to understand the mechanisms underlying the cell and tissue response to the stress; 2) to analyse how the alteration of these mechanisms can determine a disease. 3) to be familiar with the networks regulating inflammation, tissue repair, and cell growth disorders such as cancer. Specific skills A) Knowledge and understanding -knowing and understanding of the dynamic equilibrium of the homeostasis that regulate the cell life and death. -knowing and understanding of the cell-cell interactions leading to pathology. - knowing and understanding of the molecular mechanisms regulating inflammation and cancer. - knowing and understanding of the scientific methods to apply for the analysis of the cell response to different stimuli. . B) Applying knowledge and understanding - be able to use the specific terminology - be able to identify the right procedures to analyse the cell and tissue response to the stress. - be able of identifying the right procedures to analyse the gene expression in different pathologies. C) Making judgements - critical thinking through the study of the main aspects of the human pathology as well as the detailed analysis of some fundamental experiments . - learning by questioning D) Communication skills -be able to communicate what has been learned E) Learning skills - learning the specific terminology - be able to make the logical connections between the topics covered - be able to identify the most relevant topics
Channel 1
PAOLA DEL PORTO
Lecturers' profile
Program - Frequency - Exams
Course program
The course of General Pathology intends to illustrate the most relevant mechanisms underlying the inflammatory response and cancer development. In particular, it aims to provide students with basic, molecular, genetic and cellular knowledge to understand the fundamental mechanisms of immune system's response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation (inflammatory response). In addition, an introduction to the fundamental concepts involving cancer biology and hallmarks are delineated to understand how the cancer develop.
Books
Robbins e Cotran. Le basi patologiche delle malattie. Patologia Generale. V. Kumar, A.A. Abbas, J.C Aster. Edra.
Teaching mode
The module consists of 24 hours of traditional classroom teaching
Exam mode
The exam consists of a written
PAOLA DEL PORTO
Lecturers' profile
Program - Frequency - Exams
Course program
The course of General Pathology intends to illustrate the most relevant mechanisms underlying the inflammatory response and cancer development. In particular, it aims to provide students with basic, molecular, genetic and cellular knowledge to understand the fundamental mechanisms of immune system's response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation (inflammatory response). In addition, an introduction to the fundamental concepts involving cancer biology and hallmarks are delineated to understand how the cancer develop.
Books
Robbins e Cotran. Le basi patologiche delle malattie. Patologia Generale. V. Kumar, A.A. Abbas, J.C Aster. Edra.
Teaching mode
The module consists of 24 hours of traditional classroom teaching
Exam mode
The exam consists of a written
MARIA TERESA FIORILLO
Lecturers' profile
Program - Frequency - Exams
Course program
The course is aimed to guide the students through the understanding of the molecular mechanisms controlling the homeostatic balance in cells and tissues and how they are altered in diseases. The program is subdivided in credits focused on the relevant chapters of the human pathology.
During the first module of the course, the students will receive lectures focused on the understanding of the molecular mechanisms governing cell physiology and pathology: the pathways through which the cells respond to different stress such as hypoxia, ionic unbalance, ER stress, etc. as well as the pathways regulating apoptosis, necrosis and autophagy.
Molecular basis and inheritance of the Mendelian as well as multifactorial diseases with paradigmatic examples.
In particular, the following topics will be analyzed:
The pathological phenomenon as an alteration of the homeostatic balance.
Pathogenesis and disease.
Cell response to pathogens: adaptation and cell death (necrosis and apoptosis). Cellular autophagy.
Protein misfolding diseases.
Diseases with genetic, environmental and multifactorial causes.
Genetic predisposition to complex diseases: gene-environment interaction.
The topics described above will be treated in the hours of frontal teaching. The last lessons of the course will be reserved to experimental practice teaching, with a description of experimental techniques currently used for the analysis of cellular responses to stress. At the end of the course, students will have acquired knowledge of the specific topics covered in class, the ability to make connections between the different topics of the course and mastery of the specific language of the discipline.
Prerequisites
Although specific pre-med courses are not strictly required, the students need to have an appropriate level of competence in molecular and cell biology, biochemistry and physiology.
Books
Robbins: Basic Pathology 10th edition Elsevier
Rubin’s Pathology 7th edition
Pontieri: Elementi di Patologia generale e Fisiopatologia generale IV Ed. Piccin
The student will be provided with teaching materials, articles and reviews on the topics covered during the lessons.
Teaching mode
The educational format will be based on 28 hours of frontal teaching that will be given through classroom lessons, with the help of powerpoint. The last 12 hours will consist of educational workshop in the classroom.
Frequency
Attendance of the course is not compulsory but strongly recommended.
Exam mode
The assessment methods are finalized to evaluate the level of knowledge and in-depth analysis of the topics of the teaching program and the ability of reasoning, synthesis and communication of what has been learned by the student. The learning outcomes will be assessed through a written exam at the end of the course, the exam will consist of open-ended questions on the overall program related to the two modules. In the evaluation of the tests and in the assignment of the final score, the following will be taken into account: the level of knowledge of the demonstrated contents (superficial, precise and complete, complete and in-depth), the ability to apply the theoretical concepts (errors in applying the concepts, discrete, good, well established), the capacity for analysis, synthesis and interdisciplinary links (sufficient, good, excellent), the capacity for critical sense and the formulation of judgments (sufficient, good, excellent).
Bibliography
The bibliography on the individual topics covered during the course will be indicated on the teaching page on E-learning platform.
Lesson mode
The educational format of this module of the course will be based on lectures in the classroom of 2 hours each, with the aid of powerpoint, mainly focused on the description of the conditions that alter the homeostatic cellular balance and possible cellular responses and on genetic pathologies. The last 12 hours will consist in laboratory sections with description and practical tests of experimental techniques used in the field of cell biology and pathology.
MARIA TERESA FIORILLO
Lecturers' profile
Program - Frequency - Exams
Course program
The course is aimed to guide the students through the understanding of the molecular mechanisms controlling the homeostatic balance in cells and tissues and how they are altered in diseases. The program is subdivided in credits focused on the relevant chapters of the human pathology.
During the first module of the course, the students will receive lectures focused on the understanding of the molecular mechanisms governing cell physiology and pathology: the pathways through which the cells respond to different stress such as hypoxia, ionic unbalance, ER stress, etc. as well as the pathways regulating apoptosis, necrosis and autophagy.
Molecular basis and inheritance of the Mendelian as well as multifactorial diseases with paradigmatic examples.
In particular, the following topics will be analyzed:
The pathological phenomenon as an alteration of the homeostatic balance.
Pathogenesis and disease.
Cell response to pathogens: adaptation and cell death (necrosis and apoptosis). Cellular autophagy.
Protein misfolding diseases.
Diseases with genetic, environmental and multifactorial causes.
Genetic predisposition to complex diseases: gene-environment interaction.
The topics described above will be treated in the hours of frontal teaching. The last lessons of the course will be reserved to experimental practice teaching, with a description of experimental techniques currently used for the analysis of cellular responses to stress. At the end of the course, students will have acquired knowledge of the specific topics covered in class, the ability to make connections between the different topics of the course and mastery of the specific language of the discipline.
Prerequisites
Although specific pre-med courses are not strictly required, the students need to have an appropriate level of competence in molecular and cell biology, biochemistry and physiology.
Books
Robbins: Basic Pathology 10th edition Elsevier
Rubin’s Pathology 7th edition
Pontieri: Elementi di Patologia generale e Fisiopatologia generale IV Ed. Piccin
The student will be provided with teaching materials, articles and reviews on the topics covered during the lessons.
Teaching mode
The educational format will be based on 28 hours of frontal teaching that will be given through classroom lessons, with the help of powerpoint. The last 12 hours will consist of educational workshop in the classroom.
Frequency
Attendance of the course is not compulsory but strongly recommended.
Exam mode
The assessment methods are finalized to evaluate the level of knowledge and in-depth analysis of the topics of the teaching program and the ability of reasoning, synthesis and communication of what has been learned by the student. The learning outcomes will be assessed through a written exam at the end of the course, the exam will consist of open-ended questions on the overall program related to the two modules. In the evaluation of the tests and in the assignment of the final score, the following will be taken into account: the level of knowledge of the demonstrated contents (superficial, precise and complete, complete and in-depth), the ability to apply the theoretical concepts (errors in applying the concepts, discrete, good, well established), the capacity for analysis, synthesis and interdisciplinary links (sufficient, good, excellent), the capacity for critical sense and the formulation of judgments (sufficient, good, excellent).
Bibliography
The bibliography on the individual topics covered during the course will be indicated on the teaching page on E-learning platform.
Lesson mode
The educational format of this module of the course will be based on lectures in the classroom of 2 hours each, with the aid of powerpoint, mainly focused on the description of the conditions that alter the homeostatic cellular balance and possible cellular responses and on genetic pathologies. The last 12 hours will consist in laboratory sections with description and practical tests of experimental techniques used in the field of cell biology and pathology.
- Lesson code1019206
- Academic year2025/2026
- CourseBiology
- CurriculumBiotecnologico cellulare
- Year3rd year
- Semester2nd semester
- SSDMED/04
- CFU6