PHARMACOLOGY AND TOXICOLOGY

Course objectives

General skills The course is aimed at providing knowledge on drug regulation and development. It is designed to explore the fundamentals of the dynamics of drug absorption, distribution and elimination. The course illustrates the mechanism of action of the main drugs used. A further aim is provide knowledge on principles and procedures for the hazard evaluation resulting from exposure to chemicals in air, water, food and drugs. Principles of risk assessment and the definition of limits of safety of chemical agents will be also presented. Basic knowledge in chemistry, biochemistry and physiology are assumed useful knowledge for the course. Knowledge and understanding Knowledge of the factors that affect pharmacological response. Knowledge and understanding of the mechanisms of actions of the most used drugs Knowledge and understanding criteria adopted to extrapolate experimental toxicity data to humans Applying knowledge and understanding Be able to use the specific terminology Knowing how to recognize the factors affect drug response Knowing how to understand drug technical data sheets and labeling of products present in the environment Making judgements Acquire critical judgment skills on problems related to pharmacology and toxicology Communication skills Be able to communicate what has been learned during the oral exam Learning skills Be able to make the logical connections between the topics covered Be able to identify the most relevant topics

Channel 1
ROBERTA LATTANZI Lecturers' profile

Program - Frequency - Exams

Course program
GENERAL PHARMACOLOGY Principles of pharmacokinetics: absorption, distribution, metabolism and elimination of drugs. Variability in responses to drugs on a genetic basis and in physiological and pathological conditions. Principles of pharmacodynamics: sites and mechanisms of action of drugs, classes of receptors for drugs and signal transduction systems in the drug-receptor interaction; quantal and gradual dose-response relationships. Drug development. Pharmacovigilance. ANALGESICS Neuroanatomy and neurophysiology of pain Opioid and non-opioid analgesics ANTIINFLAMMATORY DRUGS Non-steroidal anti-inflammatorydrugs (NSAIDs) Paracetamol Steroidal anti-inflammatory drugs CARDIOVASCULAR DRUGS Antihypertensive drugs Antidyslipidemic agents Antiplatelets, anticoagulant and thrombolytic drugs Diuretics PHARMACOLOGY OF PSYCHIATRIC AND NEUROLOGICAL INTEREST Anxiolytic, sedative, hypnotic drugs ENDOCRINE PHARMACOLOGY Antidiabetic drugs
Prerequisites
In order to understand the contents of the course and achieve the learning objectives, the student must possess the basic knowledge of elements of general and organic chemistry, physics and biology, as well as the structure of tissues , organs and systems, and the cellular and molecular processes underlying their functioning
Books
- K. Whalen. The basis of pharmacology. III edizione. Zanichelli publisher - B.G.Katzung, A.J. Trevor, Farmacologia. Summary and multiple choice questions. Vth edition, Piccin publisher
Teaching mode
The teacher provide the lectures with traditional methods, with audiovisual aids and with scheduling of the lessons as reported on the GOMP System / Timetable System and published on the CdS website.
Frequency
Attendance of at least 75% of lectures is required to be able to take the exam
Exam mode
Oral evaluation of the topics covered in class
Bibliography
• Bibliographic material (suggested by the teacher)
Lesson mode
The teacher provide the lectures with traditional methods, with audiovisual aids and with scheduling of the lessons as reported on the GOMP System / Timetable System and published on the CdS website.
  • Lesson code1019212
  • Academic year2025/2026
  • CourseBiology
  • CurriculumGenerale
  • Year3rd year
  • Semester2nd semester
  • SSDBIO/14
  • CFU6