CELLULAR BIOLOGY AND HISTOLOGY

Course objectives

General skills This course is designed to explore the fundamentals of cell biology and tissue structure. The main goal is for learners to understand how molecular and cellular components are organized, how cells work, what are the structure and functions of differentiated cells in human tissues. High school basics in chemistry and biochemistry are assumed knowledge for the course. General and Inorganic Chemistry contents (taught in the same semester) are advantageous. The course includes classroom lectures and learning laboratory sessions. During lab sessions, students learn how the histological techniques work, how the images observed with the traditional light microscope can be interpreted for recognizing structural features of the main tissues and how to use the Virtual microscope, a learning resource freely accessible over the Web, for reviewing histological material. Specific skills A) Knowledge and understanding -knowing and understanding the chemical composition and the structure of prokaryotic and eukaryotic cells -knowing and understanding cellular activities through the functions of the specialized cellular components and organelles -knowing and understanding structural and functional properties of differentiated cells of human tissues -knowing and understanding how study methods work in cytology and histology. B) Applying knowledge and understanding - be able to use the specific terminology - practicing problem solving in Cell Biology - be able of identifying cells and tissue types in the histological preparations. C) Making judgements - critical thinking through the historical survey of the main discoveries in cell biology with the detailed analysis of the fundamental experiments - learning by questioning D) Communication skills -be able to communicate what has been learned during the oral exam E) Learning skills - learning the specific terminology - be able to make the logical connections between the topics covered - be able to identify the most relevant topics

Channel 1
MATTIA TONI Lecturers' profile

Program - Frequency - Exams

Course program
Cell Biology and Histology (8+1 CFU, 72 + 12 hrs) PART 1: CELL BIOLOGY (45 hrs) This is an introduction to cell biology where the main features of the cell and its functions are presented. Basics of the cell theory. Differences between prokaryotic and eukaryotic cells, animal vs plant cells. Orders of magnitude and cell size (3 hrs). The chemistry and macromolecules of the cell: carbohydrates, lipids, proteins and nucleic acids (6 hrs). Enzymes and chemical reactions (2 hrs). Plasma membrane: structure and function. Transport across membranes. Basic principles of signal transduction mechanisms. Extracellular matrix. Cell adhesion and cell junctions (8 hrs). Membrane bound organelles: endoplasmic reticulum, Golgi complex, endosomes, lysosomes and peroxisomes (6 hrs). Chemotrophic energy metabolism: glycolysis, fermentation, respiration and mitochondria (2 hrs). The cytoskeleton: intermediate filaments, microtubules and microfilaments (4 hrs). The nucleus: DNA, chromatin, chromosome. Nucleolus and ribosomes. DNA replication. Gene expression: the genetic code and transcription, protein synthesis and sorting. Basic principles of the regulation of gene expression (11 hrs). The cell cycle. Mitosis and meiosis (3 hrs). PART 2: HISTOLOGY (27 hrs) The second part of the course concentrates on the structure and functions of main animal tissues. Epithelia and gland tissues (8 hrs). Connective tissues (4 hrs). Cartilaginous and skeletal tissues (4 hrs). Blood, myeloid and lymphoid tissues, haematopoiesis and immune system (4 hrs). Muscular tissues (3 hrs). Nervous tissue (4 hrs). LABORATORY SESSIONS (12 hrs). Light microscope and virtual microscope observations of the main tissues.
Prerequisites
High school basics in chemistry, biochemistry and human anatomy are assumed knowledge for the course
Books
SINGLE TEXT-BOOK for both PART 1 and 2 • Dalle Donne “Citologia e Istologia” EdiSES (2019) OR PART 1: CELL BIOLOGY One textbook at student’s choice between the followings: • Alberts et al. “L’essenziale di biologia molecolare della cellula” ZANICHELLI, Quarta Ed. 2015 (2011) • Becker, Kleinsmith, Hardin E Bertoni “Il mondo della cellula” Pearson Ed 2015 (2009) • Ginelli e Malcovati “Molecole, Cellule e Organismi Edises” 2016 • Karp, “Biologia molecolare e cellulare”, V Ed., EdiSES, 2015 (2012) PART 2: HISTOLOGY One textbook at student’s choice between the followings: • Adamo et al., “Istologia di V. Monesi”, VI Edizione, Piccin 2012 (V edizione 2004) • Angelini, Botti et al., “Biologia dei Tessuti” Edi-ermes 2007 • Colombo, Olmo “Biologia Cellula e Tessuti” Edi-ermes 2014 • Junqueira, Mescher, “Istologia - Testo e Atlante”, VIII edizione, Piccin 2020(oppure VII ed. 2017) For news on textbooks and teaching materials see: https://elearning2.uniroma1.it
Frequency
Attending lectures and lab sessions is not mandatory but strongly suggested
Exam mode
The final exam includes a written exam and an oral examination. Written exam includes 60 multiple choice items for CB (Cell biology) + 30 open questions for H (Histology), some of which are based on the histological identification of virtual images. The test time is 75 minutes for CB and 30 minutes for H. At the end of the part 1 (CB) there will be an intermediate test that can be validated as CB written exam in the first period (Jan-Feb). The written exam aims to ascertain the student's ability to apply the acquired knowledge to solve questions of cell biology and to identify and classify mammalian tissues. Exams are in classroom. Grading. The score is 1 for each correct answer, 0 for each answer not given/wrong. In the H test, less than 1 can be attributed to incomplete answers. The overall grade of the written exam is the weighted average of the two exam scores [(CB + H)/3]. The minimum score is 36 for CB, and 18 for H. The minimum score to pass the written exam is 54/90 (18/30). The oral exam is mandatory for students passing the written exam with grades from 18/30 to 20/30. It is not mandatory for the other students.
Bibliography
The updated reference bibliography can be consulted on web page of the course: https://elearning2.uniroma1.it
Channel 2
MARIA ELENA MIRANDA BANOS Lecturers' profile

Program - Frequency - Exams

Course program
Cell Biology and Histology (8+1 CFU, 72 + 12 hrs) PART 1: CELL BIOLOGY (45 hrs) This is an introduction to cell biology where the main features of the cell and its functions are presented. Basics of the cell theory. Differences between prokaryotic and eukaryotic cells, animal vs plant cells. Orders of magnitude and cell size (3 hrs). The chemistry and macromolecules of the cell: carbohydrates, lipids, proteins and nucleic acids (6 hrs). Enzymes and chemical reactions (2 hrs). Plasma membrane: structure and function. Transport across membranes. Basic principles of signal transduction mechanisms. Extracellular matrix. Cell adhesion and cell junctions (8 hrs). Membrane bound organelles: endoplasmic reticulum, Golgi complex, endosomes, lysosomes and peroxisomes (6 hrs). Chemotrophic energy metabolism: glycolysis, fermentation, respiration and mitochondria (2 hrs). The cytoskeleton: intermediate filaments, microtubules and microfilaments (4 hrs). The nucleus: DNA, chromatin, chromosome. Nucleolus and ribosomes. DNA replication. Gene expression: the genetic code and transcription, protein synthesis and sorting. Basic principles of the regulation of gene expression (11 hrs). The cell cycle. Mitosis and meiosis (3 hrs). PART 2: HISTOLOGY (27 hrs) The second part of the course concentrates on the structure and functions of main animal tissues. Epithelia and gland tissues (8 hrs). Connective tissues (4 hrs). Cartilaginous and skeletal tissues (4 hrs). Blood, myeloid and lymphoid tissues, haematopoiesis and immune system (4 hrs). Muscular tissues (3 hrs). Nervous tissue (4 hrs). LABORATORY SESSIONS (12 hrs). Light microscope and virtual microscope observations of the main tissues.
Prerequisites
High school basics in chemistry, biochemistry and human anatomy are assumed knowledge for the course
Books
SINGLE TEXT-BOOK for both PART 1 and PART 2 • Dalle Donne “Citologia e Istologia” EdiSES OR SEPARATE TESTS PART 1: CELL BIOLOGY One textbook at the student’s choice between the following: • Alberts et al. “L’essenziale di biologia molecolare della cellula” ZANICHELLI • Becker, Kleinsmith, Hardin E Bertoni “Il mondo della cellula” Pearson • Ginelli e Malcovati “Molecole, Cellule e Organismi’’ EdiSES • Karp “Biologia molecolare e cellulare” EdiSES PART 2: HISTOLOGY One textbook at student’s choice between the followings: • Adamo et al. “Istologia di V. Monesi” Piccin • Angelini, Botti et al. “Biologia dei Tessuti” Edi-ermes • Colombo, Olmo “Biologia Cellula e Tessuti” Edi-ermes • Junqueira, Mescher, “Istologia - Testo e Atlante” Piccin For news on textbooks and teaching materials see: https://elearning2.uniroma1.it
Frequency
Attending lectures and lab sessions is not mandatory but is strongly advised
Exam mode
Written and oral exams are performed in person. The final exam includes a written exam and an oral examination (not compulsory, see the grading system). The written exam includes 60 multiple choice questions for Cell biology + 30 open questions for Histology, some of which are based on the identification of histological images. The time for the test is 60 minutes for Cell biology and 30 minutes for Histology. At the end of the part 1 (Cell biology) there will be an intermediate test that can be validated as the Cell biology written exam in the first official examination period (Jan-Feb). The written exam aims to ascertain the student's ability to apply the acquired knowledge to solve questions of Cell biology and to identify and classify mammalian tissues. Grading. The score is 1 for each correct answer, 0 for each answer not given/wrong. In the Histology test, less than 1 can be attributed to incomplete answers. The overall grade of the written exam is the weighted average of the two exam scores [(Cell biology + Histology)/3]. The minimum score is 36 for Cell biology, and 18 for Histology. The minimum score to pass the written exam is 54/90 (18/30). The oral exam is mandatory for students with grades from 18/30 to 20/30. It is not mandatory for the students with grades higher than 20. The oral exam can result in a maximum increase of three points.
Bibliography
The updated reference bibliography can be consulted on web page of the course: https://elearning2.uniroma1.it
Lesson mode
Learning methods include lectures, exercises and laboratory sessions. Lectures will provide the students with a comprehensive understanding of the main topics concerned with Cell biology and Histology. Students will test their knowledge on each topic by solving simple problems and exercises proposed in classroom through a learning resource (Kahoot! or similar) using their own digital devices (smartphone or tablet). Lab sessions will teach them 1) how to use the light microscope; 2) how to recognize cells and tissues on slide preparations; 3) how staining methods work; 4) how tissues are prepared for histological observation. Students will also be introduced to virtual microscopy by using learning resources freely accessible on the web (Histology guide by R.L. Sorenson and T. C. Brelje; Michigan histology and virtual microscopy), for reviewing histological material.
Channel 3
ANNA RITA ROSSI Lecturers' profile

Program - Frequency - Exams

Course program
PART 1: CELL BIOLOGY (45 hrs) This is an introduction to cell biology where the main features of the cell and its functions are presented. Basics of the cell theory. Differences between prokaryotic and eukaryotic cells, animal vs plant cells. Orders of magnitude and cell size (3 hrs). The chemistry and macromolecules of the cell: carbohydrates, lipids, proteins and nucleic acids (6 hrs). Enzymes and chemical reactions (2 hrs). Plasma membrane: structure and function. Transport across membranes. Basic principles of signal transduction mechanisms. Extracellular matrix. Cell adhesion and cell junctions (8 hrs). Membrane bound organelles: endoplasmic reticulum, Golgi complex, endosomes, lysosomes and peroxisomes (6 hrs). Chemotrophic energy metabolism: glycolysis, fermentation, respiration and mitochondria (2 hrs). The cytoskeleton: intermediate filaments, microtubules and microfilaments (4 hrs). The nucleus: DNA, chromatin, chromosome. Nucleolus and ribosomes. DNA replication. Gene expression: the genetic code and transcription, protein synthesis and sorting. Basic principles of the regulation of gene expression (11 hrs). The cell cycle. Mitosis and meiosis (3 hrs). PART 2: HISTOLOGY (27 hrs) The second part of the course concentrates on the structure and functions of main animal tissues. Epithelia and gland tissues (8 hrs). Connective tissues (4 hrs). Cartilaginous and skeletal tissues (4 hrs). Blood, myeloid and lymphoid tissues, haematopoiesis and immune system (4 hrs). Muscular tissues (3 hrs). Nervous tissue (4 hrs). LABORATORY SESSIONS (12 hrs). Light microscope and virtual microscope observations of the main tissues.
Prerequisites
High school basics in chemistry, biochemistry and human anatomy are assumed knowledge for the course
Books
SINGLE TEXTBOOK FOR BOTH PART 1 AND 2 • Dalle Donne “Citologia e Istologia” EdiSES (2019) OR PART 1: CELL BIOLOGY One textbook at student’s choice between the followings: • Alberts et al. “L’essenziale di biologia molecolare della cellula” ZANICHELLI, Quarta Ed. 2015 (2011) • Becker, Kleinsmith, Hardin E Bertoni “Il mondo della cellula” Pearson Ed 2015 (2009) • Ginelli e Malcovati “Molecole, Cellule e Organismi Edises” 2016 • Karp, “Biologia molecolare e cellulare”, V Ed., EdiSES, 2015 (2012) PART 2: HISTOLOGY One textbook at student’s choice between the followings: • Adamo et al., “Istologia di V. Monesi”, VI Edizione, Piccin 2012 (V edizione 2004) • Angelini, Botti et al., “Biologia dei Tessuti” Edi-ermes 2007 • Colombo, Olmo “Biologia Cellula e Tessuti” Edi-ermes 2014 • Junqueira, Mescher, “Istologia - Testo e Atlante”, VIII edizione, Piccin 2020 (oppure VII ed. 2017) For news on textbooks and teaching materials see: https://elearning2.uniroma1.it
Teaching mode
Learning methods include lectures, exercises and laboratory sessions. Lectures will give students a comprehensive understanding of the main topics concerned with cell biology and histology. Students will test their knowledge on each topic by solving simple problems and exercises submitted in classroom through learning resources (kahoot!, Socrative, Mentimeter) by their digital devices (smartphone or tablet). Lab sessions will teach them 1) how to use the light microscope; 2) how to recognize cells and tissues on slide preparations; 3) how staining methods work; 4) how tissues are prepared for the histological observations. Students will also be introduced to Virtual microscopy by learning resource freely accessible over the Web ((Histology guide by R.L. Sorenson and T. C. Brelje; Michigan histology and virtual microscopy), for reviewing histological material.
Frequency
Attending lectures and lab sessions is not mandatory but strongly suggested
Exam mode
The final exam includes a written exam and an oral examination. Written exam includes 60 multiple choice items for CB (Cell biology) + 30 open questions for H (Histology), some of which are based on the histological identification of virtual images. The test time is 60 minutes for CB and 30 minutes for H. At the end of the part 1 (CB) there will be an intermediate test that can be validated as CB written exam in the first period (Jan-Feb). The written exam aims to ascertain the student's ability to apply the acquired knowledge to solve questions of cell biology and to identify and classify mammalian tissues. Exams are in classroom. Grading. The score is 1 for each correct answer, 0 for each answer not given/wrong. In the H test, less than 1 can be attributed to incomplete answers. The overall grade of the written exam is the weighted average of the two exam scores [(CB + H)/3]. The minimum score is 36 for CB, and 18 for H. The minimum score to pass the written exam is 54/90 (18/30). The oral exam is mandatory for students passing the written exam with grades from 18/30 to 20/30. It is not mandatory for all the other students
Bibliography
The updated reference bibliography can be consulted on the web page of the course: https://elearning2.uniroma1.it, https://elearning.uniroma1.it/course/view.php?id=13976
Lesson mode
Learning methods include lectures, exercises and laboratory sessions. Lectures will give students a comprehensive understanding of the main topics concerned with cell biology and histology. Students will test their knowledge on each topic by solving simple problems and exercises submitted in classroom through learning resources (kahoot!, Socrative, Mentimeter) by their digital devices (smartphone or tablet). Lab sessions will teach them 1) how to use the light microscope; 2) how to recognize cells and tissues on slide preparations; 3) how staining methods work; 4) how tissues are prepared for the histological observations. Students will also be introduced to Virtual microscopy by learning resource freely accessible over the Web ((Histology guide by R.L. Sorenson and T. C. Brelje; Michigan histology and virtual microscopy), for reviewing histological material.
Channel 4
ANTONELLA DE JACO Lecturers' profile

Program - Frequency - Exams

Course program
Cell Biology and Histology (8+1 CFU, 72 + 12 hrs) PART 1: CELL BIOLOGY (45 hrs) This is an introduction to cell biology where the main features of the cell and its functions are presented. Basics of the cell theory. Differences between prokaryotic and eukaryotic cells, animal vs plant cells. Orders of magnitude and cell size (3 hrs). The chemistry and macromolecules of the cell: carbohydrates, lipids, proteins and nucleic acids (6 hrs). Enzymes and chemical reactions (2 hrs). Plasma membrane: structure and function. Transport across membranes. Basic principles of signal transduction mechanisms. Extracellular matrix. Cell adhesion and cell junctions (8 hrs). Membrane bound organelles: endoplasmic reticulum, Golgi complex, endosomes, lysosomes and peroxisomes (6 hrs). Chemotrophic energy metabolism: glycolysis, fermentation, respiration and mitochondria (2 hrs). The cytoskeleton: intermediate filaments, microtubules and microfilaments (4 hrs). The nucleus: DNA, chromatin, chromosome. Nucleolus and ribosomes. DNA replication. Gene expression: the genetic code and transcription, protein synthesis and sorting. Basic principles of the regulation of gene expression (11 hrs). The cell cycle. Mitosis and meiosis (3 hrs). PART 2: HISTOLOGY (27 hrs) The second part of the course concentrates on the structure and functions of main animal tissues. Epithelia and gland tissues (8 hrs). Connective tissues (4 hrs). Cartilaginous and skeletal tissues (4 hrs). Blood, myeloid and lymphoid tissues, haematopoiesis and immune system (4 hrs). Muscular tissues (3 hrs). Nervous tissue (4 hrs). LABORATORY SESSIONS (12 hrs). Light microscope and virtual microscope observations of the main tissues.
Prerequisites
High school basics in chemistry, biochemistry and human anatomy are assumed knowledge for the course
Books
SINGLE TEXT-BOOK for both PART 1 and 2 • Dalle Donne “Citologia e Istologia” EdiSES (2019) OR PART 1: CELL BIOLOGY One textbook at student’s choice between the followings: • Alberts et al. “L’essenziale di biologia molecolare della cellula” ZANICHELLI • Becker, Kleinsmith, Hardin E Bertoni “Il mondo della cellula” Pearson Ed • Ginelli e Malcovati “Molecole, Cellule e Organismi EdiSES” • Karp, “Biologia molecolare e cellulare”, V Ed., EdiSES. PART 2: HISTOLOGY One textbook at student’s choice between the followings: • Adamo et al., “Istologia di V. Monesi”, VI Edizione, Piccin • Angelini, Botti et al., “Biologia dei Tessuti” Edi-ermes • Colombo, Olmo “Biologia Cellula e Tessuti” Edi-ermes • Junqueira, Mescher, “Istologia - Testo e Atlante”, Piccin For news on textbooks and teaching materials see: https://elearning2.uniroma1.it
Teaching mode
Modalità di svolgimento ENG Learning methods include lectures, exercises and laboratory sessions. Lectures will give students a comprehensive understanding of the main topics concerned with cell biology and histology. Students will test their knowledge on each topic by solving simple problems and exercises submitted in classroom through learning resources (kahoot!, Socrative, Mentimeter) by their digital devices (smartphone or tablet). Lab sessions will teach them 1) how to use the light microscope; 2) how to recognize cells and tissues on slide preparations; 3) how staining methods work; 4) how tissues are prepared for the histological observations. Students will also be introduced to Virtual microscope, a learning resource freely accessible over the Web (by Michigan University), for reviewing histological material.
Frequency
Attending lectures and lab sessions is not mandatory but strongly advised
Exam mode
Exams are in classroom. The final exam includes a written exam and an oral examination. Written exam includes 60 multiple choice items for CB (Cell biology) + 30 open questions for H (Histology), some of which are based on the histological identification of virtual images. The test time is 60 minutes for CB and 30 minutes for H. At the end of the part 1 (CB) there will be an intermediate test that can be validated as CB written exam in the first period (Jan-Feb). The written exam aims to ascertain the student's ability to apply the acquired knowledge to solve questions of cell biology and to identify and classify mammalian tissues. Grading. The score is 1 for each correct answer, 0 for each answer not given/wrong. In the H test, less than 1 can be attributed to incomplete answers. The overall grade of the written exam is the weighted average of the two exam scores [(CB + H)/3]. The minimum score is 36 for CB, and 18 for H. The minimum score to pass the written exam is 54/90 (18/30). The oral exam is mandatory for students passing the written exam with grades from 18/30 to 20/30. It is not mandatory for the students that pass with a score higher than 20. The oral can lead to a maximum three-points increase.
Bibliography
The updated reference bibliography can be consulted on web page of the course: https://elearning2.uniroma1.it
Lesson mode
Modalità di svolgimento ENG Learning methods include lectures, exercises and laboratory sessions. Lectures will give students a comprehensive understanding of the main topics concerned with cell biology and histology. Students will test their knowledge on each topic by solving simple problems and exercises submitted in classroom through learning resources (kahoot!, Socrative, Mentimeter) by their digital devices (smartphone or tablet). Lab sessions will teach them 1) how to use the light microscope; 2) how to recognize cells and tissues on slide preparations; 3) how staining methods work; 4) how tissues are prepared for the histological observations. Students will also be introduced to Virtual microscope, a learning resource freely accessible over the Web (by Michigan University), for reviewing histological material.
  • Lesson code1011792
  • Academic year2024/2025
  • CourseBiology
  • CurriculumBiosanitario
  • Year1st year
  • Semester1st semester
  • SSDBIO/06
  • CFU9
  • Subject areaDiscipline biologiche