GIULIA D'AMATI

Orario di ricevimento: mercoledì ore 15-16, istituto di Anatomia Patologica, piano terra, Policlinico Umberto I

Office Hours: Wednesday 3-4 pm, Pathology Building ground floor, Policlinico Umberto I

PERSONAL INFORMATION
Name: Giulia d’Amati
Researcher unique identifier(s): ORCID iD 0000-0002-6959-691X

Nationality: Italy

CURRENT POSITION
Full Professor of Pathology, Department of Radiological, Oncological and Pathological Sciences
“Sapienza” University of Rome, Rome, Italy

EDUCATION
1994, PhD in Molecular Pathology University of Rome "La Sapienza".
1990, Board in Anatomic Pathology University of Rome “La Sapienza
1986, MD Degree University of Rome "La Sapienza"

POST-DOCTORAL TRAINING
1993 Visiting Fellow, Dept. of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA ( Dr. SM Factor)
1991-92 Research Fellow, Dept. of Pathology, UCLA, Los Angeles, USA (Dr W. Lewis)
1989-90 Fellow, Dept. of Pathology, University of Toronto, Toronto, CA (Dr MD Silver)

ACADEMIC APPOINTMENTS
2023: Dean, medical Degree course “F”, “Sapienza”, University of Rome
2019-present: Full Professor of Pathology, “Sapienza”, University of Rome
2001-2019: Associate Professor of Pathology, “Sapienza”, University of Rome
1998-2001:Assistant Professor of Pathology, “Sapienza”, University of Rome
1992-1998: Assistant Professor of Pathology, University of L’Aquila, L’Aquila, Italy
2018- present: Responsible, Academic Mobility, “F” Course (International Medical School), Sapienza University

HOSPITAL STAFF POSITION
1998-2014: Staff Pathologist, Policlinico Umberto I, “Sapienza” University Hospital
2015-2017: Acting Director of Pathology, Policlinico Umberto I, “Sapienza” University Hospital
2017-2019: Director of Pathology, Policlinico Umberto I, “Sapienza” University Hospital
2019-present: Chief, cardiovascular and Thoracic Pathology, Policlinico Umberto I, “Sapienza” University Hospital

TEACHING EXPERIENCE
1992-1998: Lecturer, University of L’Aquila School of Medicine
1998-present: Lecturer, Sapienza University, School of Medicine and Sapienza International Medical School.

SOCIETIES AND ORGANIZATIONS
2002-2007, 2010-2015, 2017-19: Counselor, Society for Cardiovascular Pathology
2013-2016- : Head, Gruppo di Patologica Cardiovascolare, Società Italiana di Anatomia Patologica e Citodiagnostica
2016- present: Head, Education Committee, Association for European Cardiovascular Pathology
2019-2023: Secretary, Society for Cardiovascular Pathology
2023-2025: President Elect, Society for Cardiovascular Pathology
2025- : President, Society for Cardiovascular Pathology
2019-present: Member, Accademia degli Olimpici, Vicenza
2023- present: Counselor, Italian Society for Anatomic Pathology and Cytology

JOURNAL EDITORIAL BOARD
2002- present: Member, Editorial Board, Cardiovascular Pathology
2013- present: Member, Editorial Board, Pathologica
2016- present: Member, Editorial Board, International Journal of Cardiology

REVIEWER ACTIVITY
2005- present: Member, reviewing panels: European Heart Journal, EMBO Molecular Medicine, Human Pathology, PLOS One, Journal of the American College of Cardiology, Human Mutation
Reviewer of grant proposals for the European Research Council
2022- present: Member, Scientific Board and evaluation committee of grant applications, Sapienza University

GRANT SUPPORT (Principal Investigator)
2023- NextGenerationEU _PNRR “HEAL ITALIA - Health Extended Alliance for Innovative Therapies,
Advanced Lab-research, and Integrated Approaches of Precision Medicine” n. 3021, project: PE00000019, Euro 1.209.781,00
2023-: PRIN (MIUR) Grant of Italian Ministry of University. The mechanistic link between genetic substrate and immune reactions in inflammatory cardiomyopathies.
2019- 2021: Istituto Pasteur Fondazione Cenci Bolognetti Mitochondrial tRNA related diseases: implementation of cellular models to evaluate the tissue-specific effects and rescuing mechanisms of therapeutic molecules. Amount: Euro 40.000
2017-2020: AMF Telethòn France: Stabilization of tRNAs as a therapeutic strategy for diseases due to mutations in mt-tRNAs. Amount: Euro 319.000
2013-2015: Telethon Italy, Grant GGP13097. Isolated domains of aminoacyl tRNA syntethases as a novel therapeutic tool for mt tRNA mutation associated disease. Amount: Euro 208.000
2013-2014: AFM Teléthon France: Isolated domains of aminoacyl tRNA syntethases as a possible therapy for mt tRNA mutation associated disease Amount Euro 30.000.
2012-2015: Institute Pasteur, Cenci Bolognetti Foundation. Disease due to mitochondrial tRNA mutations: cellular models to evaluate novel therapeutic strategies Amount: Euro 60.000
AFM Teléthon France: Isolated domains of aminoacyl tRNA syntethases as a possible therapy for mt tRNA mutation associated disease (2013-2014). Amount Euro 30.000.

GRANT SUPPORT (Head of Research Unit)
2015-2018: Italian Ministry of Health, Grant NET-2011-02347173 (2015-2018) Mechanisms and treatment of coronary microvascular dysfunction in patients with genetic or secondary left ventricular hypertrophy.
2009-2011: Grant Fondazione Roma: Evaluation of regenerative cell therapy and tissue engineering for ischemic heart disease: regional and global left ventricular quantitative analysis using non-invasive methods.
Telethon Italy, Grant GGP02333. Pathogenic mechanisms for degeneration of retinal ganglion cells in mitochondrial optic neuropathies (2006-2009).
2005-2007: Italian Ministry of Health. Inflammatory cardiomyopathies: Etiopathogenetic mechanisms and pharmacologic treatment.
2007-2009: PRIN (MIUR) Italian Ministry of University. Analysis of the oxydative metabolism of cardiac stem cells in vivo and in vivo.
2003-2005: PRIN (MIUR). Italian Ministry of University. Epidemiology and morphologic substrates of juvenile cardiac sudden death: a prospectic study in Central Italy.
2001-2003: PRIN (MIUR). Italian Ministry of University. Metabolism of thyroid hormone in heart remodelling. Amount Euro 26.159

GRANT SUPPORT FROM SAPIENZA (Principal Investigator)
2012: Disease due to mt tRNA mutations: evaluation of novel therapeutic strategies. Amount: Euro 22.000
2010 Mutations in mitochondrial tRNA genes:from yeast to human.Amount : Euro 45.000
2009: Analysis of the molecular and biochemical aspects of mitochondrial disease due to homoplasmic mtDNA mutations. Amount: Euro 15.000
2006: Systematic evaluation of mt DNA and its expression in the human body. Amount: Euro 53.600

MAIN RESEARCH INTERESTS
-Analysis of clinical, morphologic biochemical and molecular features of human mitochondrial disorders, in particular mt-tRNA related disease, on cellular models.
-Design and analysis of the effect of therapeutic molecules on cellular models of mt-DNA related disease
-Study of genetic cardiomyopathies and juvenile sudden death
-Analysis of etiopathogenic mechanisms of pathologic remodelling of coronary microcirculation.

MAIN SKILLS
-Histology, histomorphometry, immunohistochemistry, immunofluorescence, cell biology, molecular biology

PUBLICATIONS
From PubMed: 238
- h-index (Scopus, March 2025): 52
No. citations:8798 (Scopus, March 2025)

AWARDS AND HONORS
2011: Scholar in Cardiology, Italian Society of Cardiology
2015: Poster Prize, Telethon Convention, Riva Del Garda, Italy