Orari di ricevimento
Tutti i giorni previo appuntamento
Curriculum
Qualifica: Professore Associato SDD MEDS-26/A (ex MED/46); Dip.to Medicina Molecolare, “Sapienza" Univ. di Roma
Education and training
1994 Master degree in Biology, 110/110 cum laude, Univ. ‘La Sapienza’, Rome; 2001 PhD in Experimental Medicine, 4 years, Univ. of L’Aquila; 2001 Research fellow, 2 years, Project: ‘Role of HLH proteins in the pathogenesis of lymphoproliferative diseases’, Dept. of Experimental Medicine and Pathology, Univ. ‘La Sapienza’, Rome; 2002 Postgraduate Specialty School of Allergology and Clinic Immunology, 70/70 cum laude, 4 years, Univ. ‘La Sapienza’, Rome; 2002 Research fellow, from 7/2002 to 12/2003, Project: ‘Molecular and cellular analysis of Notch3 and pTalpha interplay in leukemogenesis’, Harvard Medical School, Dana Farber Cancer Institute, Dept. of Cancer, Immunology and AIDS, Prof. H. von Boehmer’s Laboratory- Boston, MA, USA.
Academic Appointments
2004-2015 Researcher/Assistant Professor of General Pathology (SSD MED/04), ‘Sapienza’, Univ. of Rome; 2009 Member of the panel of judges for the admission exam to the XXV cycle of the PhD Doctorate School of Molecular Medicine, ‘Sapienza’, Univ. of Rome; 2013-to date Member of the Teaching staff of the PhD Doctorate School of Molecular Medicine, ‘Sapienza’, Univ. of Rome; 2014-2020 Elected member of the Department Council ('Giunta di Dipartimento'), of the Department of Molecular Medicine, ‘Sapienza’, Univ. of Rome; 2014-2020 Elected member of the Faculty Council ('Giunta di Facoltà') of the Faculty of Pharmacy and Medicine, ‘Sapienza’, Univ. of Rome; 2015-present Scientific Member of the Animal Welfare Committee (OPBA) of the Departments of Molecular Medicine and Experimental Medicine, Sapienza, University of Rome; 2015 Member of the panel of judges for the final exam of the XXVII cycle of the PhD Doctorate School of Experimental Medicine and Endocrinology, Univ. of L'Aquila; 2015-present Associate Professor of Technical Sciences of Laboratory Medicine (SSD MED/46), Department of Molecular Medicine, ‘Sapienza’, Univ. of Rome; 2016 Member of the panel of judges for the admission exam to the XXXII cycle of the PhD Doctorate School of Molecular Medicine, ‘Sapienza’, Univ. of Rome; 2020-present Affiliated Researcher of Fondazione IIT (Istituto Italiano di Tecnologia), 'Center for Life Nano- & Neuro-Science' of Rome, Italy; 2021-present Participation as member of the Technical-Scientific Commitee to the 'Centro di Ricerca e Servizi Sperimentazione Preclinica e Benessere Animale (SPBA), ‘Sapienza’, Univ. of Rome; 2022-present Elected member of the Department Council ('Giunta di Dipartimento'), of the Department of Molecular Medicine, ‘Sapienza’, Univ. of Rome; 2023- Elected member of the Faculty Council ('Giunta di Facoltà') of the Faculty of Pharmacy and Medicine, ‘Sapienza’, Univ. of Rome;
Teaching experience
A.Y. 2004/05-2016/17 Course of ‘General Pathophysiology’ for the Health Professions, Bachelor of Nursing Science, ‘Sapienza’, University of Rome, CCL-Z Pomezia; A.Y. 2010/2011-2013/2014 Lectures of ‘Molecular Medicine and animal models of disease’, Master degree in Medical Biotechnology, ‘Sapienza’, University of Rome; A.Y. 2014/15-present Course of ‘Molecular Medicine and animal models of disease’, Master degree in Medical Biotechnology, ‘Sapienza’, University of Rome; A.Y. 2004/05-2014/15 Elective, as part of the Course of ‘Pathology and General Physiopathology’, Master degree in Medicine and Surgery, ‘Sapienza’, University of Rome; A.Y. 2013/14-2017/18 Elective, as part of the Course of ‘Pathology and General Physiopathology’, Master degree in Medicine and Surgery, International Medical School, ‘Sapienza’, University of Rome; A.Y. 2014/15-present Lectures of ‘Pathology’, as part of the Course of pre-clinical Methodology I', Master degree in Medicine and Surgery, ‘Sapienza’, University of Rome; A.Y. 2017/18-present Course of ‘English Language’, Master degree in Medicine and Surgery, ‘Sapienza’, University of Rome; A.Y. 2017/18-present Course of Technical Sciences of Laboratory Medicine, Bachelor of Biomedical Laboratory Technics, AOS S.Camillo-Forlanini, ‘Sapienza’, University of Rome; A.Y. 2017/18-present Course of Technical Sciences of Laboratory Medicine I-II, Bachelor of Biomedical Laboratory Technics, Pozzilli-Neuromed, ‘Sapienza’, University of Rome; A.Y.2018/19-present Course of Diagnostic methods in Anatomical Pathology, Bachelor of Biomedical Laboratory Technics, Pozzilli-Neuromed, ‘Sapienza’, University of Rome; A.Y.2018/19-present Course of in Diagnostic methods in Clinical Pathology, Bachelor of Biomedical Laboratory Technics, Pozzilli-Neuromed, ‘Sapienza’, University of Rome; A.Y. 2018/19-present Course of 'Principles of General Pathology', Bachelor of Bioinformatics (in english language), 'Sapienza', Univ. di Roma; A.Y.2018/19-present Course of Advanced methods in Laboratory Medicine, Bachelor of Biomedical Laboratory Technics, Pozzilli-Neuromed, ‘Sapienza’, University of Rome; A.Y. 2020/2021-present Participation as Tutor in the QuiD courses on 'Teaching Innovation for RTD-Bs' , organized by the 'Gruppo per la Qualità e Innovazione della Didattica' (GdL-QuID, D.R. n.2334 del 18/09/2017), Sapienza, University of Rome
Publications* (total number: 49 peer-reviewed articles; h-index 29)
*last ten years
01: Anastasiadou E, Garg N, Bigi R, Yadav S, Campese AF, Lapenta C, Spada M, Cuomo L, Botta A, Belardelli F, Frati L, Ferretti E, Faggioni A, Trivedi P. Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells. Int J Cancer. 2015 Sep 15;137(6):1491-7. doi: 10.1002/ijc.29489. Epub 2015 Mar 4. PMID: 25704079.
02: Pisano A, Preziuso C, Iommarini L, Perli E, Grazioli P, Campese AF, Maresca A, Montopoli M, Masuelli L, Sadun AA, d'Amati G, Carelli V, Ghelli A, Giordano C. Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy. Hum Mol Genet. 2015 Dec 15;24(24):6921-31. doi: 10.1093/hmg/ddv396. Epub 2015 Sep 26. PMID: 26410888.
03: Verginelli F, Adesso L, Limon I, Alisi A, Gueguen M, Panera N, Giorda E, Raimondi L, Ciarapica R, Campese AF, Screpanti I, Stifani S, Kitajewski J, Miele L, Rota R, Locatelli F. Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β. Oncotarget. 2015 Dec 22;6(41):43216-29. doi: 10.18632/oncotarget.6456. PMID: 26646450; PMCID: PMC4791227.
04: Perli E, Fiorillo A, Giordano C, Pisano A, Montanari A, Grazioli P, Campese AF, Di Micco P, Tuppen HA, Genovese I, Poser E, Preziuso C, Taylor RW, Morea V, Colotti G, d'Amati G. Short peptides from leucyl-tRNA synthetase rescue disease- causing mitochondrial tRNA point mutations. Hum Mol Genet. 2016 Mar 1;25(5):903-15. doi: 10.1093/hmg/ddv619. Epub 2015 Dec 31. PMID: 26721932; PMCID: PMC4754043.
05: Franciosa G, Diluvio G, Gaudio FD, Giuli MV, Palermo R, Grazioli P, Campese AF, Talora C, Bellavia D, D'Amati G, Besharat ZM, Nicoletti C, Siebel CW, Choy L, Rustighi A, Sal GD, Screpanti I, Checquolo S. Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression. Oncogene. 2016 Sep 8;35(36):4741-51. doi: 10.1038/onc.2016.5. Epub 2016 Feb 15. PMID: 26876201; PMCID: PMC5024153.
06: Grazioli P, Felli MP, Screpanti I, Campese AF. The mazy case of Notch and immunoregulatory cells. J Leukoc Biol. 2017 Aug;102(2):361-368. doi: 10.1189/jlb.1VMR1216-505R. Epub 2017 Mar 14. PMID: 28292944.
07: Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nunès JA, Borroto A, Alarcon B, Screpanti I, Tuosto L. A non-conserved amino acid variant regulates differential signalling between human and mouse CD28. Nat Commun. 2018 Mar 14;9(1):1080. doi: 10.1038/s41467-018-03385-8. PMID: 29540686; PMCID: PMC5852078.
08: Di Ianni M, Baldoni S, Del Papa B, Aureli P, Dorillo E, De Falco F, Albi E, Varasano E, Di Tommaso A, Giancola R, Accorsi P, Rotta G, Rompietti C, Silva Barcelos EC, Campese AF, Di Bartolomeo P, Screpanti I, Rosati E, Falzetti F, Sportoletti P. NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells. Front Oncol. 2018 Apr 20;8:105. doi: 10.3389/fonc.2018.00105. PMID: 29732315; PMCID: PMC5919960.
09: Di Stefano C, Grazioli P, Fontanella RA, De Cesaris P, D'Amore A, Regno M, Starace D, Padula F, Fiori ME, Canipari R, Stoppacciaro A, Pesce M, Filippini A, Campese AF, Ziparo E, Riccioli A. Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells. Oncotarget. 2018 Jul 20;9(56):30905-30918. doi: 10.18632/oncotarget.25773. PMID: 30112117; PMCID: PMC6089404.
10: Ferrandino F, Grazioli P, Bellavia D, Campese AF, Screpanti I, Felli MP. Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer. Front Immunol. 2018 Oct 11;9:2165. doi: 10.3389/fimmu.2018.02165. PMID: 30364244; PMCID: PMC6193072.
11: Ferrandino F, Bernardini G, Tsaouli G, Grazioli P, Campese AF, Noce C, Ciuffetta A, Vacca A, Besharat ZM, Bellavia D, Screpanti I, Felli MP. Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation. Oncogene. 2018 Dec;37(49):6285-6298. doi: 10.1038/s41388-018-0401-2. Epub 2018 Jul 23. PMID: 30038265; PMCID: PMC6284016.
12: Grazioli P, Orlando A, Giordano N, Noce C, Peruzzi G, Scafetta G, Screpanti I, Campese AF. NF-κB1 Regulates Immune Environment and Outcome of Notch- Dependent T-Cell Acute Lymphoblastic Leukemia. Front Immunol. 2020 Apr 3;11:541. doi: 10.3389/fimmu.2020.00541. PMID: 32346377; PMCID: PMC7169422.
13: Perli E, Pisano A, Pignataro MG, Campese AF, Pelullo M, Genovese I, de Turris V, Ghelli AM, Cerbelli B, Giordano C, Colotti G, Morea V, d'Amati G. Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects. FASEB J. 2020 Jun;34(6):7675-7686. doi: 10.1096/fj.201903270R. Epub 2020 Apr 18. PMID: 32304340.
14: Fontanella RA, Sideri S, Di Stefano C, Catizone A, Di Agostino S, Angelini DF, Guerrera G, Battistini L, Battafarano G, Del Fattore A, Campese AF, Padula F, De Cesaris P, Filippini A, Riccioli A. CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells. Cancer Biol Med. 2021 May 20;18(3):788–807. doi: 10.20892/j.issn.2095-3941.2020.0495. Epub ahead of print. PMID: 34018387; PMCID: PMC8330537.
15: Grazioli P, Orlando A, Giordano N, Noce C, Peruzzi G, Abdollahzadeh B, Screpanti I, Campese AF. Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia. Front Immunol. 2022 Apr 4;13:809261. doi: 10.3389/fimmu.2022.809261. PMID: 35444651; PMCID: PMC9013886.
16: Baldini E, Cardarelli S, Campese AF, Lori E, Fallahi P, Virili C, Forte F, Pironi D, Di Matteo FM, Palumbo P, Costanzo ML, D'Andrea V, Centanni M, Sorrenti S, Antonelli A, Ulisse S. Evaluation of the Therapeutic Effects of Harmine on Anaplastic Thyroid Cancer Cells. Int J Mol Sci. 2024 Jan 17;25(2):1121. doi: 10.3390/ijms25021121. PMID: 38256193; PMCID: PMC10816100.
17: Sergio I, Varricchio C, Patel SK, Del Gaizo M, Russo E, Orlando A, Peruzzi G, Ferrandino F, Tsaouli G, Coni S, Peluso D, Besharat ZM, Campolo F, Venneri MA, Del Bufalo D, Lai S, Indraccolo S, Minuzzo S, La Starza R, Bernardini G, Screpanti I, Campese AF, Felli MP. Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL. Oncogene. 2024 Aug;43(34):2535-2547. doi: 10.1038/s41388-024-03079-0. Epub 2024 Jun 21. Erratum in: Oncogene. 2024 Aug;43(34):2611. doi: 10.1038/s41388-024-03111-3. PMID: 38907003.
18: Abdollahzadeh B, Cantale Aeo NM, Giordano N, Orlando A, Basciani M, Peruzzi G, Grazioli P, Screpanti I, Felli MP, Campese AF. The NF-κB1/p50 Subunit Influences the Notch/IL-6-Driven Expansion of Myeloid-Derived Suppressor Cells in Murine T-Cell Acute Lymphoblastic Leukemia. Int J Mol Sci. 2024 Sep 13;25(18):9882. doi: 10.3390/ijms25189882. PMID: 39337370; PMCID: PMC11431874.