HUMAN PHISIOLOGY

Course objectives

General Aims At the end of the course students will know the basic physical principles and mechanisms that regulates cell physiology, with particular attention to the electrical properties of excitable cells and neuronal transmission; the function of the organs in the human body; the dynamical integration of the various organs into systems; the general mechanisms of functional control under normal conditions. The student will be aware of the main molecular and cellular mechanisms target of possible pharmacological treatments. Specific Aims: 1. Knowledge acquired by the student The student will know all the aspects of cellular and plasma membrane functioning, of the central and autonomic nervous system, of muscular contraction (skeletal smooth and cardiac muscle), of the cardiovascular system, of the respiratory system, of the urinary system, of the digestive system and of hormonal communication, and the regulation of the pH of the liquid compartments. 2. Ability to apply knowledge and understanding At the end of the course the student will understand the role of the different organ systems in the functioning of the human body and will recognize the consequences produced by the malfunctioning of the individual systems. He/she will know which are the most important correlations between structure and function of the single organs and apparatuses. He/she will know the main cellular and molecular mechanisms responsible for the correct functioning and control of the body's functions. He/she will be able to integrate the knowledge of individual systems in a general vision. 3. Critical judgment skills The lessons will be interactive; the professor will ask continuous questions to the students to stimulate them to develop critical sense and to integrate previous knowledge. These questions will also be used to evaluate and solicit students to make connections with the skills acquired previously, avoiding considering the study of the general physiology as self-standing, but integrating the physiology in the light of the knowledge already acquired (physical, chemical, biological and anatomical). 4. Ability to communicate what has been learned The student will acquire the ability to communicate all the topics covered by the program and to expose them in an integrated perspective in light of the correct functioning of the human organism. Eventually, students will be organized in small groups that will expose to the class oral presentations on specific topics related to the effect of drugs in regulating the physiological functions. 5. Ability to continue the study independently Recommended texts will provide a tool to integrate the knowledge acquired during the class. The texts will remain the reference point of the student who will know where to go to find the concepts in detail. He/she will be able to integrate these concepts with the materials available on specific online sites whose links will be suggested in class.

Channel 1
FLAVIA TRETTEL Lecturers' profile

Program - Frequency - Exams

Course program
The Program of Human Physiology (7 cfu - 56 hours with Prof. Trettel, and 1 cfu, 8 hours with Prof. Onorati) consists of two sections: Cell Physiology (20 hours) and Systems Physiology ( 46 hours) (The time schedule of the following sections may vary according to the educational needs of the class) Cell physiology: Introduction to Physiology; homeostasis concept; positive and negative feedback settings -Plasma membrane - membrane transport -Ionic channels (passive, activated by voltage, extracellular and intracellular ligand, mechanical deformation) – G-Protein coupled receptor-8 HOURS Membrane excitability - The neuron - Action Potential - Myelin - Synaptic communication - molecular basis of electrical and chemical transmission - receptors for neurotransmitters - synaptic integration - 6 HOURS Neuromuscular junction and contraction of skeletal muscle and smooth muscle - Excitability of the cardiomyocytes - 6 HOURS Systems Physiology: (Organization and physiology of the Nervous System- 8 HOURS Prof. Onorati) Organization and Physiology of the Heart and of the Vascular System - 9 HOURS Organization and Physiology of the Respiratory System - Breathing control - 7 HOURS Organization and Physiology of the renal system – 7 HOURS PH adjustment and acid-base balance - 2 HOURS Organization and Physiology of the Digestive System - 5 HOURS Hormones-6 HOURS
Prerequisites
Indispensable: knowledge of Cellular Biology, Human Anatomy, Physics, and General Chemistry is indispensable Important: the acquisition of principles of Organic Chemistry Useful: it would be useful to have some principles of Biochemistry
Books
The use of one of the following books is recommend: D.U. Silverthorn: Fisiologia Umana Un Approccio Integrato (Pearson) L. Sherwood: Fondamenti di Fisiologia Umana (PICCIN)
Frequency
According to the CCS, it is mandatory to attend the lessons. If required, due to Covid19 emergency, we will provide on-line classes (according to the schedule adopted for frontal classes) using Google Meet platform. Additional slide material, or video material will be provided on the web page of the course in e-learning platform.
Exam mode
The assessment methods are characterized by exam sessions scheduled accordingly to the academic calendar (2 for each session, plus some additional sessions). The objective of the evaluation is to certify the student's knowledge on the functioning and homeostatic control mechanisms of the human body with reference to the cellular mechanisms underlying the action of drugs. The elements taken into consideration for the evaluation are the knowledge of the subject, in all the areas covered in the course, the active participation during the lectures, the ability of reasoning demonstrated during the exam, the ability to study independently on the texts indicated. Sufficient knowledge of the topics covered, in the various parts of the program, is required for passing the exam with minimum grades. To achieve a score of 30/30 cum laude, the student must demonstrate that he/she has acquired excellent knowledge of all the topics covered during the course, being able to link them in a logical and consistent way. He/she must also demonstrate that he/she has "digested" the topics. In short, he/she must demonstrate that he/she has acquired an awareness of the proposed program of physiology that goes beyond the common 100% notional learning.
PAOLO ONORATI Lecturers' profile
Channel 2
MYRIAM CATALANO Lecturers' profile

Program - Frequency - Exams

Course program
Program of Human Physiology ( Prof. Catalano, 4 CFU, Prof. D’Alessandro, 4 CFU): (The time scheduled of the topics may vary according to the educational needs found) Introduction to Physiology; concept of homeostasis; positive and negative feedback adjustments - Plasma membrane - Membrane transport - Ionic channels (passive, activated by voltage, by extra and intracellular ligand, by mechanical deformation) - G protein coupled receptors - 4 HOURS Membrane excitability - The neuron - Action Potential - Myelin - Synaptic communication - molecular basis of electrical and chemical transmission - receptors for neurotransmitters - synaptic integration - 4 HOURS Neuromuscular junction and contraction of skeletal muscle and smooth muscle - excitability of heart muscle -6 HOURS Central Nervous System: Anatomo-physiological organization (meninges, cerebrospinal CSF and cerebral ventricle system, blood brain barrier) - Sensory physiology: somatic senses, hearing, sight. 8 HOURS Autonomic Nervous System - Anatomical organization of the sympathetic and orthosympathetic systems - Neurotransmitters, receptors, effects on target organs 4 HOURS Physiology of the endocrine system: classification of hormones - Control of hormone release - glucose homeostasis - calcium homeostasis 6 HOURS Organization and Physiology of the Heart and Cardiovascular System - 8 HOURS Respiratory System Organization and Physiology - Breathing Control - 8 HOURS Organization and Physiology of the Renal System - Regulation of pH and acid base balance - 8 HOURS Blood pressure control - 2 HOURS Organization and Physiology of the Digestive System - 6 HOURS
Prerequisites
Indispensable: knowledge of Cellular Biology, Human Anatomy, Physics, and General Chemistry is indispensable Important: the acquisition of principles of Organic Chemistry Useful: it would be useful to have some principles of Biochemistry
Books
The use of one of the following books is recommend: D.U. Silverthorn: Fisiologia Umana Un Approccio Integrato (Pearson) L. Sherwood: Fondamenti di Fisiologia Umana (PICCIN)
Frequency
According to the CCS, it is mandatory to attend the lessons.
Exam mode
The assessment methods are characterized by exam sessions scheduled accordingly to the academic calendar (2 for each session, plus some additional session ). The final exam can be a multiple choice test followed or not by oral exam. The objective of the evaluation is to certify the student's knowledge on the functioning and homeostatic control mechanisms of the human body with reference to the cellular mechanisms underlying the action of drugs. The topics presented must be treated in a language appropriate. The elements taken into consideration for the evaluation are the knowledge of the subject, in all the areas covered in the course, the use of an appropriate language, the active participation during the lectures, the ability of reasoning demonstrated during the interview examination, the ability to study independently on the texts indicated. Sufficient knowledge of the topics covered, in the various parts of the program, is required for passing the exam with minimum grades. To achieve a score of 30/30 cum laude, the student must demonstrate that he/she has acquired excellent knowledge of all the topics covered during the course, being able to link them in a logical and consistent way. He/she must also demonstrate that he/she has "digested" the topics. In short, he/she must demonstrate that he/she has acquired an awareness of the proposed program of physiology that goes beyond the common 100% notional learning.
Lesson mode
The lessons are conducted frontally with the aid of presentations. The material necessary to follow the lessons is available on e-learning. Some lessons are delivered in a flipped manner, by agreement with the students.
GIUSEPPINA D'ALESSANDRO Lecturers' profile

Program - Frequency - Exams

Course program
Program of Human Physiology ( Prof. Catalano, 4 CFU, Prof. D’Alessandro, 4 CFU): (The time scheduled of the topics may vary according to the educational needs found) Introduction to Physiology; concept of homeostasis; positive and negative feedback adjustments - Plasma membrane - Membrane transport - Ionic channels (passive, activated by voltage, by extra and intracellular ligand, by mechanical deformation) - G protein coupled receptors - 4 HOURS Membrane excitability - The neuron - Action Potential - Myelin - Synaptic communication - molecular basis of electrical and chemical transmission - receptors for neurotransmitters - synaptic integration - 4 HOURS Neuromuscular junction and contraction of skeletal muscle and smooth muscle - excitability of heart muscle -6 HOURS Central Nervous System: Anatomo-physiological organization (meninges, cerebrospinal CSF and cerebral ventricle system, blood brain barrier) - Sensory physiology: somatic senses, hearing, sight. 8 HOURS Autonomic Nervous System - Anatomical organization of the sympathetic and orthosympathetic systems - Neurotransmitters, receptors, effects on target organs 4 HOURS Physiology of the endocrine system: classification of hormones - Control of hormone release - glucose homeostasis - calcium homeostasis 6 HOURS Organization and Physiology of the Heart and Cardiovascular System - 8 HOURS Respiratory System Organization and Physiology - Breathing Control - 8 HOURS Organization and Physiology of the Renal System - Regulation of pH and acid base balance - 8 HOURS Blood pressure control - 2 HOURS Organization and Physiology of the Digestive System - 6 HOURS
Prerequisites
Indispensable: knowledge of Cellular Biology, Human Anatomy, Physics, and General Chemistry is indispensable Important: the acquisition of principles of Biochemistry is important Useful: it is useful to have some knowledge of Pharmacology
Books
D.U. Silverthorn: Fisiologia Umana Un Approccio Integrato (Pearson) L. Sherwood: Fondamenti di Fisiologia Umana (PICCIN)
Teaching mode
In the event of a stay in the state of emergency due to the pandemic from Covid 19, the lessons will be streamed on the Google Meet platform ) All information will be advertised on the e-learning page of the course. The teaching of Human Physiology consists of lectures with the students, eventually with some specific seminars. The lessons are all interactive, so the teacher stimulates the students with questions to which they, by virtue of the courses already followed, can give an answer. This allows the teacher to highligth the links between the current course and some previous courses, whose notions play a key role in the understanding of what is proposed in the class. The continuous reminding to concepts of previous courses must get the student used to not studying the proposed subject as something closed, aimed at passing the final exam, to be filed immediately afterwards, but wants to highlight a multidisciplinary study, to which the student has to be educated, and that is absolutely required for a master's degree student, now almost at the end of his training. The student will find on the e-learning platform teaching material (exam program, recommended texts, links) useful for the preparation of the exam. It is understood that all material is a guide to the exam topics, but they can never absolutely replace the recommended texts.
Frequency
In order to prove their attendance, at each lesson students will be required to provide their signature in the attendance sheet
Exam mode
The assessment methods are characterized by exam sessions scheduled accordingly to the academic calendar (2 for each session, plus some additional session ). The objective of the evaluation is to certify the student's knowledge on the functioning and homeostatic control mechanisms of the human body with reference to the cellular mechanisms underlying the action of drugs. The topics presented must be treated in a language appropriate. The elements taken into consideration for the evaluation are the knowledge of the subject, in all the areas covered in the course, the use of an appropriate language, the active participation during the lectures, the ability of reasoning demonstrated during the interview examination, the ability to study independently on the texts indicated. Sufficient knowledge of the topics covered, in the various parts of the program, is required for passing the exam with minimum grades. To achieve a score of 30/30 cum laude, the student must demonstrate that he/she has acquired excellent knowledge of all the topics covered during the course, being able to link them in a logical and consistent way. He/she must also demonstrate that he/she has "digested" the topics. In short, he/she must demonstrate that he/she has acquired an awareness of the proposed program of physiology that goes beyond the common 100% notional learning.
Lesson mode
In the event of a stay in the state of emergency due to the pandemic from Covid 19, the lessons will be streamed on the Google Meet platform ) All information will be advertised on the e-learning page of the course. The teaching of Human Physiology consists of lectures with the students, eventually with some specific seminars. The lessons are all interactive, so the teacher stimulates the students with questions to which they, by virtue of the courses already followed, can give an answer. This allows the teacher to highligth the links between the current course and some previous courses, whose notions play a key role in the understanding of what is proposed in the class. The continuous reminding to concepts of previous courses must get the student used to not studying the proposed subject as something closed, aimed at passing the final exam, to be filed immediately afterwards, but wants to highlight a multidisciplinary study, to which the student has to be educated, and that is absolutely required for a master's degree student, now almost at the end of his training. The student will find on the e-learning platform teaching material (exam program, recommended texts, links) useful for the preparation of the exam. It is understood that all material is a guide to the exam topics, but they can never absolutely replace the recommended texts.
  • Lesson code10595430
  • Academic year2024/2025
  • CoursePharmacy
  • CurriculumSingle curriculum
  • Year2nd year
  • Semester1st semester
  • SSDBIO/09
  • CFU8
  • Subject areaDiscipline biologiche