ISOTTA CHIMENTI

***********************************************************************************************************

BIOSKETCH.

Isotta Chimenti is Associate Professor in the Faculty of Pharmacy and Medicine, and Team Leader in the Experimental Cardiovascular Pathology Lab of the DSBMC department at “La Sapienza” University of Rome. Her education includes a Master of Science in Medical Biotechnology, and a PhD in Experimental Medicine. She has been a postdoc fellow at the Johns Hopkins University, at the Cedars Sinai Heart Institute, and at the Pasteur Institute – Cenci Bolognetti Foundation. Her research activity is focused on stromal cells and tissue repair, in particular on cardiac microenvironment, cardiac tissue engineering, oxidative and metabolic stress in the cardiovascular system. She has been funded as PI by several Italian National grants (PRIN, Ricerca Finalizzata, Sapienza research funding), and has participated as key staff in a European Horizon 2020 project. She co-authored over 85 Scopus indexed publications.

ACADEMIC APPOINTMENTS AND QUALIFICATIONS:
2020-2031: ASN 2018 qualification for Full Professorship in Applied Medical Technologies (06/N1-MED/46), MIUR-Italian Ministry of Education, University and Research.
2019-ongoing: Associate Professor of Applied Medical Technologies (MED/46–06/N1), Faculty of Pharmacy and Medicine, Department of Medical Surgical Sciences and Biotechnologies, "La Sapienza" University of Rome, Italy.
2011-2019: Researcher/Assistant Professor of General Pathology (MED/04–06/A2), Faculty of Pharmacy and Medicine, Department of Medical Surgical Sciences and Biotechnologies, "La Sapienza" University of Rome, Italy.

EDUCATION:
2010: Doctorate, PhD, Program of Experimental Medicine – BeMM PhD School, "Sapienza" University of Rome.
2005: Master Degree in Molecular and Cellular Medical Biotechnology, cum laude. "Sapienza" University of Rome.
2003: Bachelor of Science in Biotechnology, cum laude. "Sapienza" University of Rome.

RESEARCH ACTIVITY:
2014-ongoing: Team Leader, Experimental Cardiovascular Pathology Lab – Unit of Cardiovascular Pathology and Repair, Dep. Medical Surgical Sciences and Biotechnologies, "La Sapienza" University of Rome, Italy.
2011-2014: Researcher, Experimental Cardiovascular Pathology Lab, Dep. Medical Surgical Sciences and Biotechnologies, "La Sapienza" University of Rome, Italy.
2010 – 2011: Post-doc Research Fellow, Scholarship from Pasteur Institute, Cenci-Bolognetti Foundation. Dep. Molecular Medicine, "Sapienza" University of Rome.
2007 – 2010: Doctorate School Internship, Dep. Experimental Medicine, "Sapienza" University of Rome.
2009: Visiting scientist, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
2006 – 2007: Post-doc Research Fellow, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.

CURRENT RESEARCH INTERESTS:
Cardiac microenvironment; cardiovascular repair; cardiac stromal cells; cardiac tissue engineering; oxidative and metabolic stress the cardiovascular system; mechano-sensing.

GRANTS AND FUNDING AS PRINCIPAL INVESTIGATOR:
2023-2025: Scientific Coordinator and Unit PI, Call “PRIN 2022”, MUR-Italian Ministry of University and Research, “Elucidating MOlecular and cellular MEchanisms of cardiovascular iNsult by modified risk TObacco products (MOMENTO)”. Protocol: 20222KETLS.
2023-2026: Unit PI, Call “Ricerca Finalizzata 2021” from Italian Ministry of Health, “The possible role of MST1 in the development of vascular disease”. Protocol: RF-2021-12375256.
2022-2023: Principal Investigator, Academic Funding 2021 from “Sapienza” University of Rome for Research, “Novel perspectives in cardio-oncology: Early MEchanisms of caRdiotoxicity and strateGiEs for adjuvaNt Therapy (EMERGENT)”. Protocol: RM12117A805ED2FD.
2020-2022: Principal Investigator, Academic Funding 2019 from “Sapienza” University of Rome for Research, “Boosting cardiac regeneration through the interplay between cardiac stromal cells and the microenvironment”. Protocol: RG11916B85CDBF76.
2020-2021: Scientific coordinator, Network-Type FY2020 grant, from Joint Usage/Research Center for Radiation Disaster Medical Science, Hiroshima and Nagasaki Universities. "Effects of low dose therapeutic radiations on cardiac stromal cells for the elucidation of early mechanisms of cardiotoxicity".
2017-2021: Key staff of participant “UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA”, Horizon 2020, Call Euratom fission 2016-2017 (NFRP-2016-2017), project title: “Implications of Medical Low Dose Radiation Exposure”. Proposal number: 755523.
2017-2020: Unit PI, Call “PRIN 2015”, MIUR-Italian Ministry of Education, University and Research, “Improving efficacy, efficiency and clinical application of normothermic ex vivo lung perfusion (EVLP) to improve outcome in lung transplantation setting”. Protocol: 2015BN82FK.
2016-2019: Unit PI, Call “Ricerca Finalizzata 2013” from Italian Ministry of Health. Project title: “The role of autophagy as a protective mechanism in cardiovascular diseases: new insights into oxidative stress modulation and cardiovascular regeneration”. Protocol: GR-2013-02355401.
2014-2017: Principal Investigator and Unit PI, Call “PRIN 2012” (Starting category), MIUR-Italian Ministry of Education, University and Research. Project title: “A BioprocEss for the optimizATion of 3D cardiospHere-basEd constructs for cArdiac RegeneraTive medicine (BEAT3DHEART)”. Protocol: 20123E8FH4.
2014-2015: Task Coordinator, Grant from “Fondazione Roma” Foundation, Task title: “Task 4.1: Set-up of cell culture/regenerative medicine laboratory”, part of Unit 4: “Systems for simulated training in biomedicine”.

BIBLIOMETRICS, SCOPUS DATABASE, UPDATED March 2025:
Year of 1st pub: 2007
Scopus Author ID: 15831256400
Orcid ID: 0000-0002-0865-8814
Printed papers: 86
First/last names: 36
Total citations: 3232
H-index: 27
Cumulative IF: 470
Average IF: 5.6

TEACHING ASSIGNMENTS FOR “LA SAPIENZA” UNIVERSITY OF ROME, ITALY:
2024-ongoing: “Advanced molecular biology techniques”, Bachelor Degree in Molecular Biology, Medicinal Chemistry and Computer Science for Pharmaceutical Applications.
2019-ongoing: “General pathology and physiopathology I-II”, School of Medicine and Surgery, course E.
2017-ongoing: “General pathology and disease models” for Bachelor Degree in Biotechnology.
2013-ongoing: “Cell, Tissue and Organ Bioengineering” for Master Degree in Medical Biotechnology.
2012-ongoing: Chairman of Examining Committee, "Pathophysiology of diseases" for Nursing School.
2017-2025: “Cellular and molecular biology of stem cells” for Master of Science (II Level) in Aesthetic and Regenerative Medicine.
2018-2021: Coordinator Seminar series: “Molecular Medicine”, SSAS-Superior School for Advanced Studies.
2017-2018: Coordinator Seminar series: “Translational Medicine in Cardiology”, SSAS-Superior School for Advanced Studies.
2016-2017: Member of the Organizing Committee, Interdisciplinary Course 2016/2017 - “Physical, virtual and conceptual barriers”, SSAS-Superior School for Advanced Studies.
2012-2019: “Histology” for Nursing School.
2012-2015: Chairman of Examining Committee, "Pathophysiology of diseases" for Physiotherapy School.
2008-2018: Member of the Examining Committee for: “General Pathology” (Bachelor of Biotechnology); “Cellular and Molecular Pathology” and “Molecular Medicine” (MS in Pharmaceutical Biotechnology).

SELECTED PEER REVIEWING ACTIVITY (latest IF):
European Heart Journal (37.6), Circulation Research (16.5), Autophagy (14.6), Nature Protocols (13.1), Journal of Nanobiotechnology (10.6), Acta Biomaterialia (9.4), Pharmacological Research (9.1), Cell Death & Disease (8.1), Cell Reports (7.5), Oxidative Medicine and Cellular Longevity (7.3), Hypertension (6.9), Stem Cells Translational Medicine (5.4).

EDITORIAL ACTIVITY:
Editorial Board Member for “Current Stem Cell Research & Therapy”, ISSN 2212-3946.
Editorial Board Member for “International Journal of Molecular Science”, ISSN 1422-0067.
Academic Editor for “Stem Cells International”, ISSN: 1687-966X.
Review and Topic Editor for “Frontiers in Cardiovascular Medicine”, ISSN 2297-055X.
Topic Editor for “Frontiers in Physiology”, ISSN 1664-042X.
Guest Editor for “Journal of Visualized Experiments”, ISSN 1940-087X.

HONORS AND AWARDS:
2022-ongoing: Member of the Italian Society of Cardiology Working Group on “Molecular and Cellular Biology of the Heart”.
2021-ongoing: member of the United Nation Scientific Committee UNSCEAR - Expert Group on the evaluation of diseases of the circulatory system from radiation exposure (CircuDis).
2022: Cover image, Circulation Research, 2022 Jul 22;131(3).
2018-ongoing: Member of the European Society of Cardiology Working Group on “Cardiovascular Regenerative and Reparative Medicine”.
2019-2021: Member of the Steering Committee, SSAS-Superior School for Advanced Studies, "La Sapienza" University of Rome, Italy.
2015-2021: Junior Fellow in Life Science, SSAS-Superior School for Advanced Studies, "La Sapienza" University of Rome, Italy.
“Who’s who in the world” since 2011.
2011: Keystone Symposia Award Scholarship for the conference: “Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics 2011”, Keystone, CO, USA.