CARMINE SAVOIA

Link Lezione Endocardite Prof Savoia_IV Anno

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CURRICULUM VITAE

CARMINE SAVOIA MD FAHA FESC

• CURRENT POSITION
o Full Professor of Internal Medicine
Clinical and Molecular Medicine Department - Faculty of Medicine and Psychology - Sapienza University of Rome, Rome Italy.
o Head of Internal Medicine of Complexity Program Unit
Sant ’Andrea Hospital - Faculty of Medicine and Psychology - Sapienza University of Rome, Rome Italy.
o Director of Vascular Pathophysiology Laboratory
Clinical and Molecular Medicine Department - Sapienza University of Rome, Rome Italy.

• EDUCATION
 2001: Board certified in Internal Medicine at Sapienza University of Rome, Italy.
 1997-2001: Resident in Internal Medicine, I Clinica Medica, Sapienza University of Rome, Italy
 1995: Medical Degree Magna cum Laude from University Federico II of Naples, Italy.

• DEGREE – HONOR
 FAHA, Fellow American Heart Association (since 2012)
 FESC, Fellow European Society of Cardiology (since 2019)

• ACADEMIC APPOINTMENTS
 2022-currently: Full Professor of Internal Medicine – Clinical and Molecular Medicine Department - Faculty of Medicine and Psychology - Sapienza University of Rome - Sant’Andrea Hospital - Rome, Italy;
 2014 – currently: Visiting Professor (for Research) Institute of Cardiovascular and Medical Sciences – University of Glasgow, UK
 2007- 2022: Associate Professor of Cardiology – Clinical and Molecular Medicine Department - Faculty of Medicine and Psychology - Sapienza University of Rome - Cardiology Unit - Sant’Andrea Hospital - Rome, Italy;
 2002-2007: Research Fellow at Experimental Hypertension Laboratory of CIHR Multidisciplinary Research Group on Hypertension and Hypertension Clinic, Clinical Research Institute of Montreal, University of Montreal, Canada, and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis – Department of Medicine – Jewish General Hospital - McGill University, Montreal, Canada
 2002-2004 Research Felloship, Department of Experimental Medicine and Pathology, Sapienza University of Rome

• OTHER APPOINTMENTS
 2024-currently Faculty Contact for the Medical Area for Disability and
Specific Learning Disorders (SLD)
 2024-currently Vice-President of Degree Program in Medicine and Surgery
 2023-currently: President of International Bachelor Degree of Nursing
 2023-2024: President of the Monitoring Committee of the Faculty of Medicine
and Psychology - Sapienza University of Rome
 2022 Oct-2024 Oct: President- European Council for Cardiovascular Research (ECCR)
 2021Sept-2022 Oct: President Elect - European Council for Cardiovascular Research (ECCR)
 2016-2024: Member of the Executive Committee of the European Council for Cardiovascular Research (ECCR)
 2015-2024: Member of the Monitoring Committee of the Faculty of Medicine and Psychology - Sapienza University of Rome
 2015-2023: Vice-President of International Degree Course in Nursing - Faculty of Medicine and Psychology - Sapienza University of Rome
 2017- 2022: Member of the Executive Committee of the Italian Society of Hypertension
 2014-2017: Member of the Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA)
 2014-2017: Chair of the Italian Society of Hypertension–Lazio Regional Branch
 2009-2010: Deputy member of the board of the Italian Society of Hypertension – Lazio Regional Branch

• TEACHING AND MENTORING
 PhD program in “Pre-clinical and clinical research in biomedical and surgical sciences”
 PhD program in “Experimental Medicine”
 Medical School: 2nd, 3rd, and 6th year.
 Nursing school (2nd & 3rd year)
 Advanced Degree Course in Medical Biotechnologies (2nd year)
 Postgraduate School in Cardiology
 Postgraduate School in Internal Medicine
 Postgraduate School in Emergency Medicine
 Postgraduate School in Lung Diseases

• RESEARCH
 CURRENT SCIENTIFIC INTEREST
Clinical and experimental hypertension. Molecular and vascular biology of hypertension. Molecular mechanisms of cardiovascular remodeling. Role of modulation of angiotensin receptors and aldosterone in vascular function and remodeling. Mechanism of vascular ageing. Role of VEGFR inhibitors in hypertension. Personalized approach to hypertension and cardiovascular disease.

 COLLABORATIONS
o Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK.
o Lady Davis Institute for Medical Research, Sir Mortimer B. Davis – Department of Medicine – Jewish General Hospital - McGill University, Montreal, Canada
o University of Southern Denmark, Institute of Molecular Medicine / Dept. of Cardiovascular and Renal Research
o Center for Cardiovascular Research, Institute of Pharmacology, Charité Universitätsmedizin Berlin, Berlin, Germany
o MDC Max -Delbruck-Centrum Fur Molekulare Medizin Berlin-Buch
o Dip. Medicina Sperim. e Scienze Biochimiche Università di Tor Vergata
o Dipartimeto di Istologia ed Embriologia Medica, Sapienza Università di Roma

 RESEARCH GRANTS
o 2022 Progetti Ateneo (Sapienza University); Ruolo dell'attivazione autonomica simpatica, dell'infiammazione e dell'attivazione piastrinica in pazienti con sindrome coronarica acuta a coronarie indenni. (Principal Investigator)
o 2021 Progetti Ateneo (Sapienza University); High-field MRI advanced neuroimaging characterization of cerebrovascular damage in a mouse model of hypertension-induced cognitive impairment. (Participation)
o 2020 Progetti H2020 (Sapienza University); Hypoxic ischemic brain injury pathophysiology: a deeper understanding of hypoxia-resilient neurons and microvasculature modulation for post-cardiac arrest recovery (HIBImod) (Participation)
o 2019 Progetti di Ateneo (Sapienza University); Role of CD44 splicing variants in prostate and testis cancers as potential markers for monitoring stem cell plasticity (Participation)
o 2018 Progetti di Ateneo (Sapienza University); Oxidative stress and vascular inflammation in hypertension induced by VEGF inhibitors: role of p66Shc. (Principal Investigator)
o 2018 Grandi Attrezzature Scientifiche (Sapienza University); Integrated Platform for phenotypic, functional, and molecular profiles of mouse models. (Participation)
o 2017 Progetti di Ateneo (Sapienza University): Hypertension and cardiovascular fibrosis: role of p66Shc in aldosterone-induced fibrosis (Principal Investigator)
o 2016 Progetti di Ateneo (Sapienza University): Ruolo del peptide Natriuretico Atriale nella regolazione del processo di autofagia. Implicazioni nelle patologie cardiovascolari. (Participation)
o 2015 Grant from Italian Ministry of Education, Universities and Research (PRIN 2015): “Defective tissue repair in metabolic disorders: untangling its role and key mechanisms for novel therapeutic approaches” (Head of Unit)
o 2015 Grant for Biomedical Research from Fondazione Roma; Project: “Analysis of the authophagy-dependent regulation of lymphocyte homeostasis and autophagy manipulation in atherosclerosis” (Head of Unit)
o 2015 Progetti di Ateneo Collaborativi Sapienza University of Rome: Etiopathogenetic relevance of AMPK/SIRT1/PGC-1a/UCP2 pathway in hypertension and aging related vascular damage in an animal model of complex human disease (Participation)
o 2014 Grant for Scientific Collaborations Sapienza University of Rome: Inibitori del VEGFR ed ipertensione arteriosa (Project Leader)
o 2014 Research Grant from Daiichi Sankyo Italia: Influenza del sistema renina angiotensina sul ruolo della transglutaminasi 2 sulla funzione e struttura vascolare di ratti ipertesi: possibili implicazioni sul meccanismo di blocco recettoriale (Principal Investigator)
o 2014 Grant for Scientific Research from Stroder; Project: “Ivabradine on ventricular performance and vascular compliance in patients with post-ischemic ventricular dysfunction” (Principal Investigator)
o 2014 Progetti di Ateneo Collaborativi Sapienza University of Rome: Molecular basis of acute cardiovascular events: role of mitochondrial dysfunction (Participation)
o 2013 Progetti di Ateneo Collaborativi Sapienza University of Rome: Characterization of the vascular properties of a molecular variant of atrial natriuretic peptide as a novel risk factor for acute cardiovascular events (Participation)
o 2012 Progetti di Ateneo Collaborativi Sapienza University of Rome “Regulation of prostate carcinogenesis and tumor progression by microRNAs: Toll-like Receptors and Intercellular Communication through Exosomes” (Participation)
o 2010: Grant for Scientific Research (“Ricerche Universitarie”) from Sapienza University of Rome: “Role of angiotensin II- induced modulation of transglutaminase 2 on vascular remodeling in essential hypertension” (Principal Investigator)
o 2009: Grant for Scientific Research from Novartis Pharma; Project; “Renin Inhibition and Remodeling of Resistance Arteries in double Transgenic Rats” (Principal Investigator)
o 2009: Grant for Scientific Research (“ex Quota di Facoltà”) from Sapienza University of Rome: “Role of ACE2/Angiotensin-(1-7)/Mas Receptor activation on resistance arteries remodeling” (Principal Investigator)
o 2008: Grant for Scientific Research (“ex Quota di Facoltà”) from Sapienza University of Rome: “Renin Inhibition and Remodeling of Resistance Arteries” (Principal Investigator)

• PUBLICATIONS:
Author of more than 90 in extenso publications in international top scientific peer-reviewed journals;
H-Index 32 (SCOPUS)

• MEMBER OF THE EDITORIAL BOARD OF INTERNATIONAL SCIENTIFIC JOURNALS
o Editorial Board: Hypertension (IF 6.9)
o Deputy Editor: High Blood Pressure and Cardiovascular Prevention (IF 3.1)
o Associate Editor: Frontiers in Physiology - Clinical and Translational Physiology (IF 3.2)

• CONFERENCES AND FACULTY
Since 1998 speaker and faculty in several National and International Scientific Meeting (i.e. Scientific Session-American Heart Association; Council for High Blood Pressure Research; Società Italiana dell’Ipertensione Arteriosa; Società Italiana di Cardologia; Société Québécoise d'Hypertension Arterielle; Canadian Society of Hypertension; European Society of Hypertension; European Society of Cardiology; Internation Society of Hypertension; Interamerican Society of Hypertension; Young Investigator Group for Basic Research – European Society of Hypertension; Capri Conference; Rome Cardiology Forum)

• AWARDS AND GRANTS
He has been recipient of several Grants, and awards from National and International Scientific Institutions and Scientific Societies.
Among those:
o 2001: Fellowship and Grant for Cardiovascular Research from Italian Society of Hypertension.
o 2002-2004: Fellowship for cardiovascular research from Sapienza - University of Rome, Italy.
o 2004 Pfizer Canada Award Research Day, Clinical Research Institute of Montreal, University of Montreal, Canada;
o 2005: New Investigator Merit Award, Interamerican Society of Hypertension – supported by a grant of AHA-Council for High Blood Pressure Research;
o 2006: New Investigator Award for US Fellows – supported by an educational grant from CV Therapeutics, AHA-Council for High Blood Pressure Research”
o 2006: Young investigator award” from Italian Society of Cardiology;
o 2007: New Investigator Travel Award-supported by an educational grant from the Inter-American Society of Hypertension, Council for High Blood Pressure AHA and the National Heart, Lung, and Blood Institute;
o 2007 Sarah Strathmore Award: Cardiovascular Research Day, McGill University, Montreal, Canada;
o Numerous awards for scientific presentation at the annual meeting of American Society of Hypertension; Canadian Society of Hypertension; Société Québécoise d'Hypertension Arterielle; International Society of Hypertension; Italian Society of Hypertension.

• COMMITTEES AND JURIES
o 2024: Reviewer of Research Projects for the Austrian Science Fund (FWF)
o 2018-2020 Member of Evaluation Panel CE14-Physiologie et physiopathologie for Research grant from French National Agency (ANR)
o VQR 2004-2010 & 2011-2014 Referee for grading Scientific Research Products
o 2014-2016: Member of the National Committee for confirmation of the tenured position of Assistant Professor in Cardiology for Italian Universities.
o 2012-2013 Referee for grading National Grant Applications and Scientific Research Products
o 2010: Reviewer for the “Boston Area Diabetes Endocrinology Research Center Pilot and Feasibility Grant (BADEREC 2010).

Rome, March 6th, 2025

Autorizzo al trattamento dei miei dati personali in base al DL 196/03.