CLAUDIO DI CRISTOFANO

CLAUDIO DI CRISTOFANO
Curriculum Vitae
Senza dati anagrafici ai fini della pubblicazione
Place: Roma
Date: 08/11/2018

Part I – General Information

Full Name CLAUDIO DI CRISTOFANO

Part II – Education

Type Year Institution Notes (Degree, Experience,…)
University graduation 1994 Sapienza University of Rome
Post-graduate studies
Specialty 2001 University of Ferrara Board in Pathology

Part III – Appointments

IIIA – Academic Appointments

Start End Institution Position
Since
2008 Sapienza University of Rome Researcher (Assistant Professor) of Pathology

IIIB – Other Appointments

Start End Institution Position
Since 2018 Sapienza University of Rome Vice President, School of Medicine E, Faculty of Pharmacy and Medicine
Since 2015 Sapienza University of Rome Coordinator of the III academic year II semester of the School of Medicine E, Faculty of Pharmacy and Medicine
Since 2015 Sapienza University of Rome Coordinator I academic year, Nursing and Midwifery Sciences School, Faculty of Pharmacy and Medicine
Since 2015 Sapienza University of Rome Coordinator of the III academic year, Biomedical Laboratory Technicians School, Faculty of Pharmacy and Medicine
Since 2015 Sapienza University of Rome Coordinator I academic year, Dental Assistant School, Faculty of Pharmacy and Medicine
Since 2015 Sapienza University of Rome Coordinator of the integrated course of Etiopathogenesis of the diseases, Dental Assistant School, Faculty of Pharmacy and Medicine

Part IV – Work experience

Year Institution Occupation or position held
Since 2008 Pathology Unit, ICOT Latina, “Sapienza” University of Rome, Department of Medico-Surgical Sciences and Biotechnologies Assistant Medical Director (Staff Pathology)
2002-2007 Pathology Unit, Santa Chiara University Hospital of Pisa, Department of Surgical, Molecular and Ultrastructural Pathology, University of Pisa. Assistant Medical Director (Staff Pathology)
2001 Pathology Unit, San Camillo-Forlanini Hospital, Roma Assistant Medical Director (Staff Pathology)

Part V – Teaching experience

Year Institution Lecture/Course
Since 2010 Sapienza University of Rome Professor of Pathology, Medical School, Faculty of Pharmacy and Medicine
Since 2012 Sapienza University of Rome Professor of Pathology, Medical Pathology Graduate School, Faculty of Pharmacy and Medicine
Since 2009 Sapienza University of Rome Professor of Histology, Nursing School, Faculty of Pharmacy and Medicine
Since 2009 Sapienza University of Rome Professor of Pathology, Physiotherapists School, Faculty of Pharmacy and Medicine
Since 2009 Sapienza University of Rome Professor of Histology and Pathology, Dental Assistant School, Faculty of Pharmacy and Medicine
Since 2009 Sapienza University of Rome Professor of Molecular Pathology, Biomedical Laboratory Technicians School Faculty of Pharmacy and Medicine
Since 2009 Sapienza University of Rome Professor of Pathology, Nursing and Midwifery Sciences School, Faculty of Pharmacy and Medicine

Part VI - Society memberberships, Awards and Honors

Year Title
Since 2001 Member of International Academy of Pathology (IAP) – Italian Section- Società Italiana di Anatomia Patologica (SIAPEC)
Since 2010 Member of United States Canadian Academy of Pathology (USCAP)
Since 2009 Member of European Society of Pathology (ESP)
Since 2009 Member of European Society of Uropathology
Since 2015 Member of Molecular Pathology Italian Group (SIAPEC)
Since 2010 Member of Uropatology Italian Group (SIAPEC)
Since 2010 Member of Dermatopathology Italian Group (SIAPEC)
Since 2017 Member of Ematopatology Italian Group (SIAPEC)

Part VII - Funding Information [grants as PI-principal investigator or I-investigator]

Year Title Program Grant value
2004 Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine Elli-Lilly 2004 project European
2007 Comparative analysis of gene expression profile and proteomics of pancreatic carcinoma AIRC 2007 Regional
2008 Significato prognostico dell'espressione di ezrina nell'osteosarcoma Sapienza research founds Local
2008 Approccio genomico allo studio della patologia umana Sapienza research founds Local
2009 Analisi della struttura ossea con micro-TC nelle teste femorali espiantate in corso di interventi per protesi di anca: confronto diagnostica-anatomia patologica Sapienza research founds Local
2009 I farmaci anti-TNF-a nella cura della psoriasi. Sapienza research founds Local
2010 Rilevanza clinica della conta e della caratterizzazione molecolare delle cellule tumorali circolanti nel carcinoma della mammella: implicazioni per l'individualizzazione delle terapie. Sapienza research founds Local
2012 Prognostic value of circulating melanoma cells in patients with Stage I-IIIA melanoma Sapienza research founds Local
2013 Molecular mechanisms of metastasis formation in osteosarcoma Sapienza research founds Local
2014 Osteosarcoma: “whole-exome” from diagnosis to therapy. Sapienza research founds Local
2015 Il sequenziamento di nuova generazione nello studio dell'osteosarcoma Sapienza research founds Local
2016 The role of KMT2C in osteosarcoma carcinogenesis, progression and resistance to therapy Sapienza research founds Local
2017 KMT2C function in osteosarcoma carcinogenesis and progression Sapienza research founds Local

Part VIII – Research Activities

Keywords Brief Description
Pathology Claudio Di Cristofano is an experienced pathologist whose main interest is focused on bone and soft tissues, skin, kidney and breast pathology with special regard to cancer diseases.
From 2001 to 2007 he has been chief of Microdissection (LCM) and Tissue Microarray (TMA) of Molecular Pathology Unit at University of Pisa.
His research activity is discovery of oncogenic mechanisms and therapeutic targets in solid tumors by use of molecular methods in cell and tissues samples. In particular he is devoted to identifying novel therapeutic molecular target by FISH, IF, IHC and molecular analysis in tumors sample. During this activity he has used same molecular methods that allow to investigate the protein localization and co-localization in tissue and cell samples.
Since 2008 He is a Researcher (Assistant Professor) of Pathology at ICOT Hospital in Latina, “Sapienza” University of Rome, Department of Medico-Surgical Sciences and Biotechnologies

Oncology
Cancer
Osteosarcoma
Molecular Pathology
Part IX – Summary of Scientific Achievements

Product type Number Data Base Start End
Papers [international] 64 IRIS 2004 2018
Papers [national] 2 IRIS 2004 2018
Books [scientific] 4 IRIS 2004 2018
Books [teaching] 2 IRIS 2004 2018

Total Impact factor 171,248
Impact factors (last 10 years) 141,959
Total Citations 1058
Average Citations per Product 16
Hirsch (H) index 22
Normalized H index* 2,2
*H index divided by the academic seniority.

Part X– Selected Publications

1. Pathological characteristics and prognostic effect of peritumoral capsule penetration in renal cell carcinoma after tumor enucleation. Minervini A, Rosaria Raspollini M, Tuccio A, Di Cristofano C, Siena G, Salvi M, Vittori G, Sebastianelli A, Lapini A, Serni S, Carini M. Urol Oncol. 2014 Jan;32(1):50. e15-22. doi: 10.1016/j.urolonc.2013.07.018. Epub 2013 Nov 13. (IF 2.768) (Citations Scopus 28). (Scopus 2-s2.0-84890792845; ISIweb WOS:000347243300103).

2. VHL and HIF-1α: gene variations and prognosis in early-stage clear cell renal cell carcinoma. Lessi F, Mazzanti CM, Tomei S, Di Cristofano C, Minervini A, Menicagli M, Apollo A, Masieri L, Collecchi P, Minervini R, Carini M, BevilacquaG. Med Oncol. 2014 Mar;31(3):840. doi: 10.1007/s12032-014-0840-8. Epub 2014 Jan 21. (IF 2.634) (Citations Scopus 17). (Scopus 2-s2.0-84892460418; ISIweb WOS:000337728700006).
3. An unusual case of spleen metastasis from carcinoma ex pleomorphic adenoma of the parotid gland. Rossi L, Giordani E, Fontana A, Di Cristofano C, Cavallaro G, Bagni O, Filippi L, Bianchi L, Rinaldi G, Congedi FP, Papa A, Caruso D, Verrico M, Silecchia G, Tomao S. World J Surg Oncol. 2014 Jan 23; 12:18. doi: 10.1186/1477-7819-12-18. (IF 1.408) (Citations Scopus 1). (Scopus 2-s2.0-84892741947; ISIweb WOS:000335346200001).

4. Correlation of the Rac1/RhoA pathway with ezrin expression in osteosarcoma.Chiappetta C, Leopizzi M, Censi F, Puggioni C, Petrozza V, Rocca CD, Di Cristofano C. Appl Immunohistochem Mol Morphol. 2014 Mar;22(3):162-70. doi: 10.1097/PDM.0000000000000033. (IF 2.012) (Scopus citations 9). (Scopus 2-s2.0-84910129287; ISIweb WOS:000333057100002).

5. BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma. Chiappetta C, Proietti I, Soccodato V, Puggioni C, Zaralli R, Pacini L, Porta N, Skroza N, Petrozza V, Potenza C, Della Rocca C, Di Cristofano C. Appl Immunohistochem Mol Morphol. 2015 Mar;23(3):172-7. doi: 10.1097/PAI.0000000000000071. (IF 2.012) (Scopus citations 19). (Scopus 2-s2.0-84925872171; ISIweb WOS:000350987300002).

6. Weaknesses of histological analysis in celiac disease diagnosis: new possible scenarios. Picarelli A, Borghini R, Donato G, Di Tola M, Boccabella C, Isonne C, Giordano M, Di Cristofano C, Romeo F, Di Cioccio G, Marcheggiano A, Villanacci V, Tiberti A. Scand J Gastroenterol. 2014 Nov;49(11):1318-24. doi: 10.3109/00365521.2014.948052. Epub 2014 Aug 12. (IF 2.361) (Scopus citations 13). (Scopus 2-s2.0-84942683795; ISIweb WOS:000345603400007).

7. Breast metastasis and lung large-cell neuroendocrine carcinoma: First clinical observation. Papa A, Rossi L, Verrico M, Di Cristofano C, Moretti V, Strudel M, Zoratto F, Minozzi M, Tomao S.. Clin Respir J. 2015 Sep 14. doi: 10.1111/crj.12385. (IF 1.512) (Scopus citations 1). (Scopus 2-s2.0-84951781656; ISIweb WOS:000409266000005).

8. Computed Tomography Perfusion of Prostate Cancer: Diagnostic Value of Quantitative Analysis. Osimani M, Bellini D, Pastore A, Palleschi G, Di Cristofano C, Rengo M, Porta N, Boboc GI, Della Rocca C, Carbone A, Petrozza V, Laghi A. J Comput Assist Tomogr. 2016 Sep-Oct;40(5):740-5. doi: 10.1097/RCT.0000000000000432. .(IF 1.470) (Scopus citations 0). (Scopus 2-s2.0-84970024948; ISIweb WOS:000385372300011).

9. Whole-exome analysis in osteosarcoma to identify a personalized therapy. Chiappetta C, Mancini M, Lessi F, Aretini P, De Gregorio V, Puggioni C, Carletti R, Petrozza V, Civita P, Franceschi S, Naccarato AG, Rocca CD, Mazzanti CM, Di Cristofano C. Oncotarget. 2017 Jul 5;8(46):80416-80428. doi: 10.18632/oncotarget.19010. eCollection 2017 Oct 6. (IF 5.008) (Scopus citations 5). (Scopus 2-s2.0-85030640077; ISIweb WOS:000412465700029).

10. Increased Plasma Proneurotensin Levels Identify NAFLD in Adults With and Without Type 2 Diabetes. Barchetta I, Cimini FA, Leonetti F, Capoccia D, Di Cristofano C, Silecchia G, Orho-Melander M, Melander O, Cavallo MG. J Clin Endocrinol Metab. 2018 Jun 1;103(6):2253-2260. doi: 10.1210/jc.2017-02751. (IF5.83) (Scopus citations 1). (Scopus 2-s2.0-85045992089; ISIweb WOS:000434881400021).

11. Neurotensin Is a Lipid-Induced Gastrointestinal Peptide Associated with Visceral Adipose Tissue Inflammation in Obesity. Barchetta I, Cimini FA, Capoccia D, Bertoccini L, Ceccarelli V, Chiappetta C, Leonetti F, Di Cristofano C, Silecchia G, Orho-Melander M, Melander O, Cavallo MG. Nutrients. 2018 Apr 23;10(4). pii: E526. doi: 10.3390/nu10040526. (IF 4.196) (Scopus citations 0). (Scopus s2.0-85046000026; ISIweb WOS:000435182900142).

12. The nuclear-cytoplasmic trafficking of a chromatin-modifying and remodelling protein (KMT2C), in osteosarcoma. Chiappetta C1, Puggioni C1, Carletti R1, Petrozza V1, Della Rocca C1, Di Crisfofano C. Oncotarget. 2018 Jul 17;9(55):30624-30634. doi: 10.18632/oncotarget.25755. eCollection 2018 Jul 17. (IF 5.008) (Scopus citations 0). (Scopus 2-s2.0-85050146044).