Orari di ricevimento
Martedi mattina (previo appuntamento)
Curriculum
Full Name Carolina Scagnolari
Part II – Education
Type Year Institution Notes
University graduation 2000 Sapienza University of Rome, Italy Degree in Biological Sciences (110/110 cum laude)
Thesis title: Pharmacokinetics and pharmacodynamics of recombinant interferon beta in patients with relapsing-remitting multiple sclerosis
PhD 2006 Sapienza University of Rome, Italy PhD in Experimental Medicine.
Thesis title: SARS virus and IFN system: induction and antiviral activity
Specialty 2008 Sapienza University of Rome, Italy Specialization in Microbiology and Virology (70/70 cum laude)
Thesis title: The interferon system in viral infections of the respiratory tract
Part III – Appointments
IIIA – Academic Appointments
Start End Institution Position
2001 2005 Sapienza University of Rome, Italy PhD student in Experimental Medicine (17th cycle)
2001 2001 University of Pisa, Retrovirus center, Italy Visiting scientist. Study topic: Use of real time PCR for the detection of HIV-DNA. Study period: 1 month
2003 2003 AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy Visiting scientist. Study topic: Analysis of the sensitivity of SARS coronavirus to the antiviral effect of interferons. Study duration: 2 months
2005 2005 Joan and Sanford I. Weill Medical College, Cornell University, New York City, USA Visiting scientist. Study topic: Development of molecular techniques for the detection of West Nile virus. Period of study: 1 month
2006
Sapienza University of Rome, Italy Research fellow (Borsista di Ricerca) Sponsor: scholarship in the biomedical field, ANLAIDS -ONLUS -National Association for the Fight against AIDS
2007
Sapienza University of Rome, Italy Research fellow (Borsista di Ricerca) Sponsor: scholarship within the VIROLAB project, Agostino Gemelli University Hospital-Catholic University of the Sacred Heart, Rome.
2009
Sapienza University of Rome, Italy Research fellow (Borsista di Ricerca) Sponsor: scholarship within the project 'Infection control in the weak and immunocompromised'.
2010
Sapienza University of Rome, Italy Research fellow (Borsista di Ricerca) Sponsor: scholarship in the biomedical field, ANLAIDS -ONLUS -National Association for the Fight against AIDS
2010-2017
Sapienza University of Rome, Italy Assistant professor at the Faculty of Pharmacy and Medicine, Department of Molecular Medicine, SSD MED07
2018-2024 Sapienza University of Rome, Italy Associate professor at the Faculty of Pharmacy and Medicine, Department of Molecular Medicine, SSD MED07
2024-ongoig. Sapienza University of Rome, Italy. Full Professor at the Faculty of Pharmacy and Medicine, Department of Molecular Medicine, SSD MEDS03-A
2018 2029 ASN - National Scientific Qualification for the role of Full Professor in Microbiology and Clinical Microbiology. SC 06/A3 SSD MED 07. From 08/09/2018-08/09/2029 Call: 2016-2018 (Fifth quarter)
IIIB – Other Appointments
Start End Institution Position
2019 ongoing Sapienza University of Rome, Italy Member of the committee of PhD in Life Science (collegio docenti)
2023 ongoing Sapienza University of Rome, Italy Member of the Quality Assurance Commission of PhD in Life Science (commissione qualità)
2020 ongoing Sapienza University of Rome, Italy President of the Master in Molecular Virology (II level)
2020 ongoing Sapienza University of Rome, Italy Member of the Commission for Research and the Third Mission of the Department of Molecular Medicine, Faculty of Pharmacy and Medicine
2016-2022 Sapienza University of Rome, Italy President of the Bachelor Degree in Nursing (course T), Isernia, Molise
2013-2016 Sapienza University of Rome, Italy Vice president of the Bachelor Degree in Nursing (course T), Isernia, Molise
2016-2020; 2019-2023 Sapienza University of Rome, Italy Member of the Board of Teachers and Researchers of the Faculty of Pharmacy and Medicine (Giunta di Facoltà)
2012 ongoing
Sapienza University of Rome, Italy
Tutor and supervisor of experimental theses at Master in Molecular Virology (II level)
2012 ongoing Sapienza University of Rome, Italy Tutor and supervisor/co-supervisor of experimental theses at the degree course in Biology and degree course in Biotechnology
Part IV – Teaching experience
Year Institution Lecture/Course
2023-2024 Sapienza University of Rome, Italy Lecturer at the Course: Beyond the frontiers of translational immunology (lesson: Induction and viral-mediated evasion strategies of interferon response). PhD students in Life Sciences and Biochemistry
2022-2023 Sapienza University of Rome, Italy Lecturer at the Course: Introduction to Immunology (Lesson: Innate immune receptors and interferon response). PhD students in Life Sciences and Biochemistry
2018-2019 Sapienza University of Rome, Italy Lecturer at the Course: Introduction to Immunology (lesson: Induction and viral-mediated evasion strategies of interferon esponses). PhD students in Life Sciences and Biochemistry
2021-ongoing Sapienza University of Rome, Italy Medicine and Surgery High Technology (HT); Single-cycle Master's Degree. Virology module within the Microbiology course (2 CFU). SSD MED07 (SSD MEDS-03/A)
2020- ongoing Sapienza University of Rome, Italy Medicine and surgery - Medicina e chirurgia "F"; Single-cycle Master's Degree. Virology module within the Microbiology course (1 CFU). English course. SSD MED07 (SSD MEDS-03/A)
2011- ongoing Sapienza University of Rome, Italy Medicine and surgery - Medicina e chirurgia "E" (Polo Pontino, Latina); Single-cycle Master's Degree. Virology module within the Microbiology course (3 CFU). SSD MED07 (SSD MEDS-03/A)
2019-ongoing Sapienza University of Rome, Italy Bachelor’s degree course in Physiotherapy Degree Course A. Microbiology module within Pathophysiologycal basis of diseases course (2 CFU).SSD MED07 (SSD MEDS-03/A)
2022-ongoing Sapienza University of Rome, Italy Bachelor’s degree course in Environment and Workplace Prevention Techniques. Microbiology module within Elements of Biology course (2 CFU).SSD MED07 (SSD MEDS-03/A)
2022-ongoing Sapienza University of Rome, Italy Bachelor’s degree course in Neurophysiopathology techniques. Microbiology module within Cellular and molecular basis of life course (2 CFU).SSD MED07 (SSD MEDS-03/A)
2011-ongoing Sapienza University of Rome, Italy Bachelor’s degree course in Nursing - CourseT degree - Molise Region ASL 2- Pentria Isernia. Microbiology module within Pathophysiologycal basis of diseases course (2 CFU); Coordinator of the course. SSD MED07 (SSD MEDS-03/A)
2018-ongoing Sapienza University of Rome, Italy Bachelor’s degree course in Nursing - CourseT degree - Molise Region ASL 2- Pentria Isernia. Seminar activities (3 CFU); Coordinator
2017-ongoing Sapienza University of Rome, Italy Bachelor’s degree course in Nursing - Course T degree - Molise Region ASL 2- Pentria Isernia. Elective Teaching Activities (ADE, 2/4 CFU); Coordinator
2012-ongoing Sapienza University of Rome, Italy Lecturer at the Second Level Master's Course in Molecular Virology. SSD MED07 (SSD MEDS-03/A)
2020-2021; 2022-2023 Sapienza University of Rome, Italy Lecturer at the First Level Master's Course in Management of the critical patient in case of catastrophic events (CBRNE/ NaTech)
2011-2016 Sapienza University of Rome, Italy Bachelor’s degree course in Dental Hygiene, Molise Region ASL 2- Pentria Isernia. Microbiology module within Molecular Bases of Life course (2 CFU); Coordinator of the course. SSD MED07 (SSD MEDS-03/A)
2016-2023 Sapienza University of Rome, Italy Bachelor’s degree course in Dental Hygiene, Cassino campus. Microbiology module within Molecular Bases of Life course (2 CFU); Coordinator of the course. SSD MED07 (SSD MEDS-03/A)
2015 St. John’s University, College of Pharmacy & Health Sciences, (Campus in Rome) Lecturer in the seminar entitled: 'Viral illnesses, public health effects, and treatment', Department of Pharmaceutical Sciences. Seminar date: 2/02/2015 (English). SSD MED07 (SSD MEDS-03/A)
2002-2007 Sapienza University of Rome, Italy Bachelor’s degree course in Nursing - Colleferro campus. Lecturer in Applied Biology within Biology and Biochemistry course.
Part V - Society memberships, Awards and Honors
Year Title
2002-ongoing Member of the Italian Society of Microbiology
2018-ongoing Member of the Italian Society of Virology
2004 Sivim Award 2004. Best oral communication at the 3° FORUM SIVIM, “Virus and cancers”, Rome, Italy, 2004. Title of the oral presentation: “Molecular markers of HPV infection in HIV-negative or positive women”.
2014 ICAR-CROI Awards 2014. Title of oral presentation: “Interleukin-32: Expression, interaction with IFN and clinical significance in HIV-1-infection", Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA, 2014. Award received at the ICAR congress in Italy.
2014 Special Jury Price 2014 released by Prof. G. Silvestri, Prof B.H Hahn and Prof GS Deeks for the best oral communication at the Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA, 2014. Title of oral presentation: “Interleukin-32: expression, interaction with IFN and clinical significance in HIV-1-infection". Award received at the ICAR congress in Italy.
2015 ICAR-CROI Awards 2015. Title of the oral presentation: “Regulation of IL-32 expression by a promoter polymorphism and microrna29b in HIV-1 infected patients”. Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, USA, 2015. Award received at the ICAR congress in Italy.
2016 2016 Gilead Award. Title of the project: “Analysis of immunogenetic patterns, viral burden and cardiovascular diseases: a new integrative model for the management of HIV-1 patients suffering from cardiovascular damage”. Dr B. Roosjen (General Manager Gilead Science Italy) and Dr. C. Coparale (Italian Fellowship Program Jury).
2019 ICAR-CROI Awards 2019. Title of oral presentation: “Increased SAMHD1 correlates with ISGs in HIV-1– infected patients” (Presenter: Maura Statzu, Mentor/Tutor C Scagnolari). Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, USA, 2019. Award received at the ICAR congress in Italy.
2020 ICAR-CROI Awards 2020. Title of oral presentation: “Decreased expression of mucosal type I IFN response in HPV-infected MSM patients”. (Presenter: Letizia Santinelli, Mentor/Tutor Carolina Scagnolari). Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA, 2020. Award received at the ICAR congress in Italy.
2021 2021 Gilead Award. Title of the project: “Development of a new integrative approach for monitoring SARS-CoV-2 infection-induced versus vaccine-acquired innate and T cell immunity in HIV-1 infected patients”. Prof. A. Lazzarin (HIV Fellowship Program Jury), Dr V. Confalone (General Manager Gilead Science Italy).
2021 ICAR-CROI Awards 2021. Title of oral presentation: “Impairment of type I/III IFN response in the upper airways of SARS-CoV-2 patients” presented as Science Spotlight to Virtual CROI (Presenter: Federica Frasca, Mentor/Tutor Carolina Scagnolari). Conference on Retroviruses and Opportunistic Infections (CROI), Virtual (online), 2021. Award received at the ICAR congress in Italy
2022 ICAR-CROI Awards 2022. Title of oral presentation: “Longitudinal study of anti-Spike antibodies in children after SARS-CoV-2 infection” (Presenter: Federica Frasca, Mentor/Tutor Carolina Scagnolari). Conference on Retroviruses and Opportunistic Infections (CROI), Denver, USA, 2022. Award received at the ICAR congress in Italy
2022 ICAR-CROI Awards 2022. Title of oral presentation: “Detection of circulating and airway autoantibodies to IFN in severe COVID-19 patients” (Presenter: Federica Frasca, Mentor/Tutor Carolina Scagnolari). Conference on Retroviruses and Opportunistic Infections (CROI), Denver, USA, 2022. Award received at the ICAR congress in Italy.
2023 ICAR-CROI Awards 2023. Title of oral presentation: “Inflammasone but not IFN-I/III response is altered in children with long COVID” (Presenter: Luca Maddaloni, Mentor/Tutor Carolina Scagnolari). Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, USA, 2023. Award received at the ICAR congress in Italy.
2024 ICAR-CROI Awards 2024. Title of oral presentation: “MPXV replication induces an IFN response and is suppressed by IFN-γ” (Presenter: Alessandra D’Auria, Mentor/Tutor Carolina Scagnolari). Conference on Retroviruses and Opportunistic Infections (CROI), Denver, USA, 2024. Award received at the ICAR congress in Italy
Part V – Editorial duties
Year Journal’s name
2019-ongoing Editor of Archives of Virology (Springer)
2013-2018 Member of the Advisory Board of Archives of Virology (Springer)
2018-2021 Member of the Editorial Board of New Microbiologica (Edizioni Internazionali srl)
2021-ongoing Editor of New Microbiologica (Edizioni Internazionali srl)
2022-ongoing Editorial board member of Microorganisms (MDPI)
Part VI - Funding Information [grants as PI-principal investigator or I-investigator]
Year
Description
2023 BANDO MUR - Fondo investimenti edilizia universitaria 2021-2035. D.M. 10 dicembre 2021, n. 1274 - lett. C. Title of the project: Characterization of host immune responses to acute and chronic viral infection by multiparameter flow cytometry. Role: PI
2022 Call for applications for Visiting Professors to carry out joint research and teaching activities, Sapienza University of Rome, Italy. Grant assigned to Prof. Raphael Viscidi (Johns Hopkins University, Baltimore, Sapienza University of Rome). Role: PI
2022 INF-ACT PE13–RESEARCH NODE2 (Arthropod Vectors and Vector-Borne Diseases). National Recovery and Resilience Plan (NRRP), Investment 1.3 funded from the European Union – NextGeneration EU Partnerships extended (PE) 13 Emerging Infectious Diseases (Project n. PE00000007). Duration 36 months: October 2022-October 2025. Role: Research component (NODE2). *This grant value has been assigned to C. Scagnolari’s Unit
2022 PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2022. Title of the project: Assessment of the missing link between Human Endogenous Retroviruses and gut Microbiota-Immunity Axis in the colorectal cancer pathogenesis (HERMIA), Prot. 2022Y8FZCP. Role: PI of the Sapienza Research Unit. Duration 24 months: 09/30/2023- 09/29/2025. *This grant value has been assigned to C. Scagnolari’s Unit
2022 Scientific Research - Research Projects Financing, Sapienza University of Rome, Italy. Title of the project: Immune response and microbiota signature following natural SARS-CoV-2 infection and vaccination in HIV-infected individuals. Duration 12 months. Role: PI
2021 Fellowship Program 2021-Gilead, Italy. Title of the project: “Development of a new integrative approach for monitoring SARS-CoV-2 infection-induced versus vaccine- acquired innate and T cell immunity in HIV-1 infected patients”. Duration 12 months. Role: PI
2020 Scientific Research - Research Projects Financing, Sapienza University of Rome, Italy. Title of the project: Analysis of type I-III IFN signature and in vitro responsiveness to IFN-I stimulation in transplant recipients: development of new model to identify patients with the highest risk of CMV infections and rejections. Duration 12 months. Role: PI
2019 ACTIONS CONCERTEES INTERPASTEURIENNES (ACIP), Pilot Project proposal, Pasteur Institute, Paris, France. Title of the project: Dengue virus-mosquito-host interactions: assessing type I interferon mediated immune processes and immunological effects of mosquito salivary glands on Dengue infection. ACIP project A-2019. Components: Dr. Cantaert T. IP in Cambodia; Dr. Duffy D. 3 IP in Paris; Dr. Coulibaly IZ 4 IP in Côte d'Ivoire. Duration 2 years. Role: PI/Coordinator (International project)
2019 Scientific Research - Research Projects Financing, Sapienza University of Rome, Italy. Title of the project. Determination of Interferon stimulated genes inhibiting mouse papillomavirus replication in mouse keratinocytes and mediating in vivo anti papillomavirus response. Duration 12 months. Role: PI
2017 Scientific Research - Research Projects Financing, Sapienza University of Rome, Italy. Title of the project. Microbiota and type I/III interferon gene signature in HPV infected patients: pilot study based on comprehensive analysis in view of a potential therapeutic approach. Duration 12 months. Role: PI
2016 Fellowship Program 2016-Gilead, Italy.
Title of the project: Analysis of immunogenetic patterns, viral burden and cardiovascular diseases: a new integrative model for the management of HIV-1 patients suffering from cardiovascular damage. Duration 12 months. Role: PI
2015 Scientific Research - Funding Research Projects, Sapienza University of Rome, Italy.
Title of the project: Interplay between type I interferon activation and viral burden in determining differences in cardiovascular risk in HIV-1 patients. Duration 12 months. Role: PI
2014 Scientific Research - Funding Research Projects, Sapienza University of Rome, Italy.
Title of the project: Interferon lambda activation and epigenetic regulation during progression of human papilloma virus infection to anogenital cancer. Duration 12 months. Role: PI
2013 Scientific Research - Funding Research Projects, Sapienza University of Rome, Italy. Title of the project: In vitro and ex-vivo characterization of the role of type I and III interferon and inflammatory immune response in the natural history of mosquito-borne USUTU virus infection. Duration 12 months. Role: PI
2013 ACTIONS CONCERTEES INTERPASTEURIENNES (ACIP), Pilot Project proposal, Pasteur Institute, Paris, France. Title of the project: Mosquito borne USUTU virus infection: dissecting virus molecular epidemiology and in vitro and ex-vivo characterization of innate immune responses. ACIP project A07-2013. Components: Dr Beniamino Caputo, IP Sapienza; Dr Cornelia Ceianu IP Romania; Dr Diawo Diallo, IP Senegal. Duration 2 years. Role: PI/Coordinator (International project)
2012 Pasteur Institute -Fondazione Cenci Bolognetti, Rome, Italy.
Title of the project: Interleukin 32: molecular expression, epigenetic regulation, and biological activities in human immunodeficiency virus 1-infection. Duration 3 years. Role: PI
2012 Scientific Research - Funding Research Projects, Sapienza University of Rome, Italy. Title of the project: Impact of Rhinovirus infections, antiviral innate immune response and environmental factors on wheezing illnesses and asthma. Duration 12 months. Role: PI
Part VII – Research Activities
Prof. C. Scagnolari coordinates and carries out the research activities of the Virology Laboratory (Department of Molecular Medicine), which are mainly dedicated to antiviral innate immunity and virus-host interaction. For years, Carolina Scagnolari's research has focused on the analysis of the activation of the interferon system (IFN type I, II and III) and its antiviral activity, a key component of innate immunity, during acute and/or chronic viral infections of public health interest. In this context, part of her past research has been devoted to the identification of factors associated with response to IFN therapy. In addition, she has helped to demonstrate that sustained and increased IFN production promotes the exacerbation of several viral infections, but at the same time, reduced expression of these antiviral systems due to viral and host factors can contribute to severe disease. C. Scagnolari's interdisciplinary collaboration with other national and international research groups has allowed the clinical significance of viral load to be assessed and the molecular epidemiology of emerging viruses to be characterised in detail. In recent years, C. Scagnolari's scientific interest has also focused on the analysis of the effect of oral bacterial supplementation in HIV-1 and HPV infections, with important findings on inflammation and T-cell immunity.
Keywords Brief Description
Antiviral innate immunity;
Virus-host interaction
IFN response;
Anti-IFN autoantibodies C. Scagnolari’s scientific activity is mainly focused on the following topics:
• Factors associated with response to interferon (IFN) therapy
Throughout her career, C. Scagnolari has been investigating the host factors that need to be considered to explain the heterogeneity of clinical response to IFN therapy in patients with various chronic diseases such as multiple sclerosis, chronic hepatitis C infection and cryoglobulinemia. These studies have helped to highlight the important role of anti-IFN neutralizing/binding autoantibodies, IFN-related genes/microRNAs and IFN gene variants (IL-28B; IFNlamda4) in IFN-mediated response and have provided insights into the host factors that influence the outcome of IFN treatment. The main results of this research are reported in the following selected publications:
Scagnolari C, et al. Curr Drug Targets. 2017
Riva E, et al. J Viral Hepat. 2012
Scagnolari C, et al. Clin Microbiol Infect. 2012
Scagnolari C, et al. Virol J. 2010
Scagnolari C, et al. J Neurol. 2007
Scagnolari C, et al. Clin Exp Immunol. 2007
Santantonio T, et al. J Hepatol. 2006
Scagnolari C, et al.Clin Diagn Lab Immunol. 2003
Bagnato F, et al. Neurology. 2002
Scagnolari C, J et al. Interferon Cytokine Res. 2002
• Emerging viruses and IFN resistance
Over the years, a major focus of C. Scagnolari's research has been the study of host-virus interactions at the cellular and molecular level, particularly in the context of viruses and IFNs. During the SARS-CoV-1 outbreak in 2003, C. Scagnolari was one of the first researchers to describe the resistance of SARS-CoV-1 to IFN action. Encouraging results have led her group to investigate IFN activity against a number of emerging viruses, including human metapneumovirus, pandemic H1N1 influenza virus, mosquito-borne viruses, SARS-CoV-2 and monkeypox virus. She has also made several major contributions to the antiviral characterisation of IFNalpha and IFNlambda subtypes. Results related to this research topic have been reported in the following selected publications:
Clementi N, et al. J Infect Dis. 2020 Scagnolari C, et al. J Infect Dis. 2017 Cacciotti G, et al. Virology. 2015 Scagnolari C, et al. J Gen Virol. 2013 Scagnolari C, et al. Viral Immunol. 2011 Scagnolari C, et al., J Interferon Cytokine Res. 2011 Scagnolari C, et al. Antivir Ther. 2004 Antonelli G, et al. Lancet. 2003
• IFN production in acute and chronic viral infections
In recent years, C. Scagnolari has spent much of her time in collaborative, multidisciplinary research settings, and through this experience it has become increasingly clear that although IFNs are universally recognised for their antiviral and immunostimulatory functions, they can also cause decreased host resistance to some viral infections. In this context, C. Scagnolari has made significant contributions to our understanding of the protective or deleterious effects of TLRs, type I/III IFNs and ISG responses in patients infected with HIV-1 and/or HPV, in patients suffering from dengue disease and in those with respiratory viral infections, including those caused by SARS-CoV-2. More recently, she found that patients with severe COVID-19 or coinfection with SARS-COV-2 and HIV develop anti-IFN neutralizing/binding autoantibodies and that an alteration in IFN response characterizes long COVID. In the last decades, C. Scagnolari, in collaboration with Prof. Raphael Viscidi (Johns Hopkins University, USA, Visiting professor in her laboratory), has also carried out research to study the IFN response in COVID-19 patients and to evaluate a recently discovered mouse papillomavirus (MmuPV1) as a model for the analysis of innate immune responses to papillomavirus infection. The main results of this research are reported in the following selected publications:
Fracella M, et al. Eur J Immunol. 2024
Pierangeli A, et al. Front Immunol. 2022
Scordio M, et al. Clin Immunol. 2022
Bitossi C, et al. Microb Pathog. 2022
Frasca F, et al. Eur J Immunol. 2022
Santinelli L, et al. J Med Virol. 2021
Scagnolari C, et al. Virus Res. 2021
Upasani V, et al. Front Immunol. 2020
Scagnolari C, et al. J Infect. 2020
Pinacchio C, et al. AIDS. 2020
Scagnolari C, et al. J Virol. 2020
Santinelli L, et al. Cytokine. 2019
Pierangeli A, et al. J Clin Virol. 2018
Monteleone K, et al. BMC Infect Dis. 2015
Cannella F, et al. Immunobiology. 2015
Monteleone K, et al. Med Microbiol Immunol. 2014
Cannella F, et al. Med Microbiol Immunol. 2014
Selvaggi C, et al. J Infect. 2014
Scagnolari C, et al. Clin Vaccine Immunol. 2009
Viral load;
Viral epidemiology
Although her research interests have largely focused on IFN responses to viral infections, C. Scagnolari has also contributed to important studies on the genetic diversity and molecular epidemiology of respiratory viruses, including respiratory syncytial virus (RSV) and SARS-CoV-2, HPV and polyomaviruses. She has also participated in studies on the relationships between RSV or HPV load, viral clearance dynamics and disease severity. The results of this research are reported in the following selected publications:
Pierangeli A, et al. J Infect. 2023
Prezioso C, et al. Microorganisms. 2021
Midulla F, et al. J Infect Dis. 2020
Midulla F, et al. J Infect Dis. 2019
Scagnolari C, et al. Eur Respir J. 2017
Pierangeli A, Clin Microbiol Infect. 2016
Pierangeli A, et al. Euro Surveill. 2014
Pierangeli A, et al. J Infect. 2012
Scagnolari C, et al. Med Microbiol Immunol. 2012
Pierangeli A, et al. Clin Microbiol Infect. 2012
Midulla F, et al. Eur Respir J. 2012
Pierangeli A, et al. Clin Microbiol Infect. 2010
Serraino D, et al. Clin Microbiol Infect. 2007
Bacteriotherapy;
Microbiota;
T cell subsets
C. Scagnolari has also investigated the ability of oral bacteriotherapy to modulate epithelial barrier functions, microbiota composition, neuroinflammation, IFN pathways, T cell subsets (e.g. Th17) and T cell immune activation in people living with HIV. More recently, she found that clearance of anal HPV infection was more frequently observed in MSM patients receiving oral bacteriotherapy supplementation and that a specific microbiota signature characterised SARS-COV-2 positive patients. The results of this research are reported in the following selected publications:
Santinelli L, et al. J Med Virol. 2023
Cavallari EN, et al. Biomedicines. 2021
d'Ettorre G, et al. Front Med (Lausanne). 2020
Ceccarelli G, et al. Lancet Gastroenterol Hepatol. 2020
Pinacchio C, et al. J Immunol Res. 2018
Ceccarelli G, et al. Nutrients. 2017
Ceccarelli G, et al. Brain Behav. 2017
d'Ettorre G, et al. Immun Inflamm Dis. 2017
Invited speaker at conference
2023 C. Scagnolari. VIRUS RESPIRATORI in era post- pandemica, Title: Interferon e virus respiratori: un’interazione complessa. SIV-ISV. LECCE, 12/15/2023
2023 C. Scagnolari. SYMPOSIUM: The battle between the virus and the host: an ongoing dynamic process. Title: Type I Interferon in HIV and SARS-CoV-2 infection: following the mechanistic thread. 15° CONGRESSO NAZIONALE Italian Conference on AIDS and Antiviral Research (ICAR). Bari, 06/14-16/2023
2023 C. Scagnolari. Microambiente e HPV. Title: La regione anale risposta innata e HPV. 2° FOCUS MULTIDISCIPLINARE SU PAPILLOMAVIRUS (HPV). Una patologia diffusa e complessa. Pisa, 06/08/2023
2022 C. Scagnolari. SESSION PLENARIA NUOVE EVIDENZE SU SARS-CoV-2/COVID-19 Title: SARS-CoV-2 e Interferone: un equilibrio complesso Carolina Scagnolari (Roma). 50° Congresso Nazionale SIM. Naples, 09/19/2022
2021 C. Scagnolari. SESSION 13: COVID-19: PATHOGENESIS, PREVENTION AND CONTROL 5TH Title: SARS-CoV-2 and antiviral interferon response: who wins at tug-of-war? National congress of the Italian Society for Virology. 07/06/2021 Virtual
2021 C. Scagnolari. SYMPOSIUM AUDITORIUM CONCORDIA Antiviral immune control. Title: Interferon pathways in controlling HIV and COVID infections "13° Congresso Nazionale ICAR: Italian Conference on AIDS and Antiviral Research". 22/10/2021
2019 C. Scagnolari. Title: Gut damage in HIV infection: pitfalls and potential interventions. Evento InAction: “Italian Network ACuTe HIV InfectiON” Rome, 05/21/2019
2017 C. Scagnolari. Title: Impatto dei probiotici sulla produzione cellulare di interferoni SIMPOSIO MICROBIOMA, IMMUNOATTIVAZIONE E COMORBIDITA’ HIV-CORRELATE", 12/22/2017
2017 C. Scagnolari. Title: HIV: Interferon type I and viral immune evasion Dal laboratorio alla clinica. Aggiornamento sulle infezioni virali croniche, Sapienza University of Rome. Rome, 12/04/2017
2017 C. Scagnolari. Title: HIV: Interferon type I and viral immune evasion Dal laboratorio alla clinica. Aggiornamento sulle infezioni virali croniche, Sapienza University of Rome. Rome, 12/04/2017
2016 C. Scagnolari. Title: Interferon e virus: delicato equilibrio tra yin e yang. 44° Congresso Nazionale della Società Italiana di Microbiologia. Pisa 09/25-28/2016
2015 C. Scagnolari. Title: New insights into the role of type I Interferon (IFN) and IFN stimulated genes responses in HIV-1 infection. Giornata Romana di Immunologia (in inglese), Auditorium Istituto della I Clinica Medica. Rome, 06/08/2015
2014 C. Scagnolari. Title: Interferon e virus: uno scontro tra titani. Aperitivi scientifici. Istituto Pasteur Italia- Fondazione Cenci Bolognetti. Rome, 03/11/2014
2013 C. Scagnolari. Title: Infezioni respiratorie e immunità innata in età pediatrica. RESEARCH HIGHLIGHTS: VIROLOGIA. 41° CONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI MICROBIOLOGIA. Riccione, 10/13-16/2013
2011 C. Scagnolari. Title: Host factors associated with non-response to pegylated interferon plus ribavirin in HCV infected patients. VIII Forum SIVIM, “I virus dell’Epatite, patogenesi, terapia e monitoraggio dell’infezione: attualità e prospettive. Rome 12/12/2011.
Organization/Chair of Scientific Events:
2024 Organization of the pre-congress course and chair: C. Scagnolari.
Pre-congress course: Addressing viral persistence today and tomorrow. https://www.icar2024.it/pages/corsiPrecongressuali/index.php
Italian Conference on AIDS and Antiviral Research (ICAR), Rome, June 19, 2024
2024 Chair: C. Scagnolari. SESSION 2: VIRAL PATHOGENESIS AND DISEASE
8th national congress of the Italian Society for Virology (SIV). Bologna, July 7-9, 2024
2023 Chair: C. Scagnolari. Bench studies of viral infections. Italian Conference on AIDS and Antiviral Research (ICAR), BARI June 2023
All Publications (2002-2024)
List of all the publications. For each publication report title, authors, reference data, journal IF/year (if applicable), citations (scopus date 22th July 2024); press/media release (if any)*.
1. Conti MG, Piano Mortari E, Nenna R, Pierangeli A, Sorrentino L, Frasca F, Petrarca L, Mancino E, Di Mattia G, Matera L, Fracella M, Albano C, Scagnolari C, Capponi M, Cinicola B, Carsetti R, Midulla F. SARS-CoV-2-specific mucosal immune response in vaccinated versus infected children. Front Cell Infect Microbiol. 2024;14:1231697. doi: 10.3389/fcimb.2024.1231697. IF 4.6, citations 0
2. Fracella M, Mancino E, Nenna R, Virgillito C, Frasca F, D'Auria A, Sorrentino L, Petrarca L, La Regina D, Matera L, Di Mattia G, Caputo B, Antonelli G, Pierangeli A, Viscidi RP, Midulla F, Scagnolari C. Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID. Eur J Immunol. 2024:e2350682. doi: 10.1002/eji.202350682. IF 4.5, citations 0, press/media release (if any)* see below
3. Fracella M, Oliveto G, Roberto P, Cinti L, Gentile M, Coratti E, D'Ettorre G, Cavallari EN, Romano F, Santinelli L, Maddaloni L, Frasca F, Scagnolari C, Antonelli G, Pierangeli A. The Epidemiology of Anal Human Papillomavirus (HPV) in HIV-Positive and HIV-Negative Women and Men: A Ten-Year Retrospective Observational Study in Rome (Italy). Pathogens. 2024;13(2):163. doi: 10.3390/pathogens13020163. IF 3.3, citations 0
4. Wondeu ALD, Abakar MF, Frasca F, Nodjikouambaye AZ, Abdelrazakh F, Naibei N, Dzomo GRT, Djimtoibaye D, Mad-Toingue J, Scagnolari C, Antonelli G, Linardos G, Russo C, Perno CF, Yandai FH, Atturo S, Hiscott J, Colizzi V, Cappelli G, Ngueadoum N, Haroun A, Choua O, Moussa AM. Presence of neutralizing SARS-CoV-2 antibodies in asymptomatic population of N'Djamena, Chad. Immun Inflamm Dis. 2024;12(1):e1154. doi: 10.1002/iid3.1154. IF 3.1, citations 0
5. Maddaloni L, Santinelli L, Bugani G, Cacciola EG, Lazzaro A, Lofaro CM, Caiazzo S, Frasca F, Fracella M, Ajassa C, Leanza C, Napoli A, Cinti L, Gaeta A, Antonelli G, Ceccarelli G, Mastroianni CM, Scagnolari C, d'Ettorre G. Differential expression of Type I interferon and inflammatory genes in SARS-CoV-2-infected patients treated with monoclonal antibodies. Immun Inflamm Dis. 2023;11(10):e968. doi: 10.1002/iid3.968. IF 3.1, citations 0
6. Filardo S, Di Pietro M, Bozzuto G, Fracella M, Bitossi C, Molinari A, Scagnolari C, Antonelli G, Sessa R. Interferon-ε as potential inhibitor of Chlamydia trachomatis infection. Microb Pathog. 2023;185:106427. doi: 10.1016/j.micpath.2023.106427. IF 3.3, citations 0
7. Pierangeli A, Nenna R, Fracella M, Scagnolari C, Oliveto G, Sorrentino L, Frasca F, Conti MG, Petrarca L, Papoff P, Turriziani O, Antonelli G, Stefanelli P, Palamara AT, Midulla F. Genetic diversity and its impact on disease severity in respiratory syncytial virus subtype-A and -B bronchiolitis before and after pandemic restrictions in Rome. J Infect. 2023;87(4):305-314. doi: 10.1016/j.jinf.2023.07.008. IF 14.3, citations 18, press/media release (if any)* see selected publications
8. Fracella M, Scordio M, Sorrentino L, D'Auria A, Ingenito R, Gentile M, Pierangeli A, Antonelli G, Scagnolari C, Frasca F. In Vitro Virucidal Effects of Ultraviolet Light Prototypes on RNA viruses. New Microbiol. 2023 May;46(2):161-169. IF 1.5, citations 1
9. Sorrentino L, Toscanelli W, Fracella M, De Angelis M, Frasca F, Scagnolari C, Petrarca L, Nenna R, Midulla F, Palamara AT, Nencioni L, Pierangeli A. NRF2 Antioxidant Response and Interferon-Stimulated Genes Are Differentially Expressed in Respiratory-Syncytial-Virus- and Rhinovirus-Infected Hospitalized Children. Pathogens. 2023;12(4):577. doi: 10.3390/pathogens12040577. IF 3.3, citations 5
10. Sorrentino L, Fracella M, Frasca F, D'Auria A, Santinelli L, Maddaloni L, Bugani G, Bitossi C, Gentile M, Ceccarelli G, Turriziani O, Mastroianni CM, Antonelli G, d'Ettorre G, Pierangeli A, Scagnolari C. Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients. Microorganisms. 2023;11(3):689. doi: 10.3390/microorganisms11030689. IF 4.1, citations 4
11. Mori M, Quaglio D, Calcaterra A, Ghirga F, Sorrentino L, Cammarone S, Fracella M, D'Auria A, Frasca F, Criscuolo E, Clementi N, Mancini N, Botta B, Antonelli G, Pierangeli A, Scagnolari C. Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity. Microorganisms. 2023;11(2):314. doi: 10.3390/microorganisms11020314. IF 4.1, citations 9
12. Santinelli L, Rossi G, Gioacchini G, Verin R, Maddaloni L, Cavallari EN, Lombardi F, Piccirilli A, Fiorucci S, Carino A, Marchianò S, Lofaro CM, Caiazzo S, Ciccozzi M, Scagnolari C, Mastroianni CM, Ceccarelli G, d'Ettorre G. The crosstalk between gut barrier impairment, mitochondrial dysfunction, and microbiota alterations in people living with HIV. J Med Virol. 2023;95(1):e28402. doi: 10.1002/jmv.28402. IF 6.8, citations 5
13. Fracella M, Oliveto G, Sorrentino L, Roberto P, Cinti L, Viscido A, Di Lella FM, Giuffrè F, Gentile M, Pietropaolo V, Prezioso C, Palma E, Recine N, Palaia I, Scagnolari C, Antonelli G, Pierangeli A. Common Microbial Genital Infections and Their Impact on the Innate Immune Response to HPV in Cervical Cells. Pathogens. 2022 Nov 16;11(11):1361. doi: 10.3390/pathogens11111361. IF 3.3, citations 2
14. Oliveto G, Scagnolari C, Frasca F, Sorrentino L, Matera L, Nenna R, Viscido A, Scordio M, Petrarca L, Maria Zicari A, Gentilini E, D'Ettorre G, Ceccarelli G, Midulla F, Antonelli G, Pierangeli A. The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults. Cytokine. 2022; 158:155997. doi: 10.1016/j.cyto.2022.155997. IF 3.8, citations 1
15. Pierangeli A, Gentile M, Oliveto G, Frasca F, Sorrentino L, Matera L, Nenna R, Viscido A, Fracella M, Petrarca L, D'Ettorre G, Ceccarelli G, Midulla F, Antonelli G, Scagnolari C. Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ω. Front Immunol. 2022;13:873232. doi: 10.3389/fimmu.2022.873232. IF 7.3, citations 12
16. Scordio M, Frasca F, Santinelli L, Sorrentino L, Pierangeli A, Turriziani O, Mastroianni CM, Antonelli G, Viscidi RP, d'Ettorre G, Scagnolari C. High frequency of neutralizing antibodies to type I Interferon in HIV-1 patients hospitalized for COVID-19. Clin Immunol. 2022;241:109068. doi: 10.1016/j.clim.2022.109068. IF 8.6, citations 4
17. Bitossi C, Viscido A, Prezioso C, Brazzini G, Trancassini M, Borrazzo C, Passerini S, Frasca F, Scordio M, Sorrentino L, Oliveto G, Fracella M, D'Auria A, Selvaggi C, Cimino G, Midulla F, Pierangeli A, Antonelli G, Moens U, Pietropaolo V, Scagnolari C. High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis. Microb Pathog. 2022;169:105644. doi: 10.1016/j.micpath.2022.105644. IF 3.8, citations 1
18. Romeo A, Iacovelli F, Scagnolari C, Scordio M, Frasca F, Condò R, Ammendola S, Gaziano R, Anselmi M, Divizia M, Falconi M. Potential Use of Tea Tree Oil as a Disinfectant Agent against Coronaviruses: A Combined Experimental and Simulation Study. Molecules. 2022;27(12):3786. doi: 10.3390/molecules27123786. IF 4.2, citations 13
19. Meza G, Galián F, Jaimes-Bernal C, Márquez FJ, Sinangil F, Scagnolari C, Real LM, Forthal D, Caruz A. IFNL4 genotype influences the rate of HIV-1 seroconversion in men who have sex with men. Virulence. 2022;13(1):757-763. doi: 10.1080/21505594.2022.2066612. IF 5.2, citations 0
20. Frasca F, Scordio M, Santinelli L, Gabriele L, Gandini O, Criniti A, Pierangeli A, Angeloni A, Mastroianni CM, d'Ettorre G, Viscidi RP, Antonelli G, Scagnolari C. Anti-IFN-α/-ω neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity. Eur J Immunol. 2022;52(7):1120-1128. doi: 10.1002/eji.202249824. IF 5.4, citations 28, press/media release (if any)* see selected publications
21. Pinacchio C, Scordio M, Santinelli L, Frasca F, Sorrentino L, Bitossi C, Oliveto G, Viscido A, Ceci FM, Celani L, Ceccarelli G, Antonelli G, Mastroianni CM, d'Ettorre G, Scagnolari C. Analysis of serum microRNAs and rs2910164 GC single-nucleotide polymorphism of miRNA-146a in COVID-19 patients. J Immunoassay Immunochem. 2022;43(4):347-364. doi: 10.1080/15321819.2022.2035394. IF 0.7, citations 8
22. Sorrentino L, Silvestri V, Oliveto G, Scordio M, Frasca F, Fracella M, Bitossi C, D'Auria A, Santinelli L, Gabriele L, Pierangeli A, Mastroianni CM, d'Ettorre G, Antonelli G, Caruz A, Ottini L, Scagnolari C. Distribution of Interferon Lambda 4 Single Nucleotide Polymorphism rs11322783 Genotypes in Patients with COVID-19. Microorganisms. 2022;10(2):363. doi: 10.3390/microorganisms10020363. IF 4.5, citations 4
23. Ceci FM, Fiore M, Gavaruzzi F, Angeloni A, Lucarelli M, Scagnolari C, Bonci E, Gabanella F, Di Certo MG, Barbato C, Petrella C, Greco A, Vincentiis M, Ralli M, Passananti C, Poscia R, Minni A, Ceccanti M, Tarani L, Ferraguti G. Early Routine Biomarkers of SARS-CoV-2 Morbidity and Mortality: Outcomes from an Emergency Section. Diagnostics (Basel). 2022;12(1):176. doi: 10.3390/diagnostics12010176. IF 3.0, citations 19
24. Petrarca L, Nenna R, Di Mattia G, Frassanito A, Castro-Rodriguez JA, Rodriguez Martinez CE, Mancino E, Arima S, Scagnolari C, Pierangeli A, Midulla F. Bronchiolitis phenotypes identified by latent class analysis may influence the occurrence of respiratory sequelae. Pediatr Pulmonol. 2022;57(3):616-622. doi: 10.1002/ppul.25799. IF 3.1, citations 8
25. Frassanito A, Nenna R, Arima S, Petrarca L, Pierangeli A, Scagnolari C, Di Mattia G, Mancino E, Matera L, Porta D, Rusconi F, Midulla F. Modifiable environmental factors predispose term infants to bronchiolitis but bronchiolitis itself predisposes to respiratory sequelae. Pediatr Pulmonol. 2022;57(3):640-647. doi: 10.1002/ppul.25794. IF 3.1, citations 5
26. Farmani AR, Mahdavinezhad F, Scagnolari C, Kouhestani M, Mohammadi S, Ai J, Shoormeij MH, Rezaei N. An overview on tumor treating fields (TTFields) technology as a new potential subsidiary biophysical treatment for COVID-19. Drug Deliv Transl Res. 2022;12(7):1605-1615. doi: 10.1007/s13346-021-01067-5. IF 5.4, citations 4
27. Filardo S, Di Pietro M, Frasca F, Diaco F, Scordio M, Antonelli G, Scagnolari C, Sessa R. Potential IFNγ Modulation of Inflammasome Pathway in Chlamydia trachomatis Infected Synovial Cells. Life (Basel). 2021;11(12):1359. doi: 10.3390/life11121359. IF 3.2, citations 4
28. Cavallari EN, Ceccarelli G, Santinelli L, Innocenti GP, De Girolamo G, Borrazzo C, Spagnolello O, Scagnolari C, Arcieri S, Ciardi A, Pierangeli A, Mastroianni CM, d'Ettorre G. Clinical Effects of Oral Bacteriotherapy on Anal HPV Infection and Related Dysplasia in HIV-Positive MSM: Results from the "HPVinHIV" Trial. Biomedicines. 2021;9(11):1738. doi: 10.3390/biomedicines9111738. IF 4.7, citations 0
29. Prezioso C, Moens U, Oliveto G, Brazzini G, Piacentini F, Frasca F, Viscido A, Scordio M, Guerrizio G, Rodio DM, Pierangeli A, d'Ettorre G, Turriziani O, Antonelli G, Scagnolari C, Pietropaolo V. KI and WU Polyomavirus in Respiratory Samples of SARS-CoV-2 Infected Patients. Microorganisms. 2021;9(6):1259. doi: 10.3390/microorganisms9061259. IF 4.9, citations 5
30. Papoff P, Caresta E, Luciani S, Pierangeli A, Scagnolari C, Giannini L, Midulla F, Montecchia F. The starting rate for high-flow nasal cannula oxygen therapy in infants with bronchiolitis: Is clinical judgment enough? Pediatr Pulmonol. 2021;56(8):2611-2620. doi: 10.1002/ppul.25439. IF 4.0, citations 8
31. Santinelli L, De Girolamo G, Borrazzo C, Vassalini P, Pinacchio C, Cavallari EN, Statzu M, Frasca F, Scordio M, Bitossi C, Viscido A, Ceccarelli G, Mancone M, Mastroianni CM, Antonelli G, d'Ettorre G, Scagnolari C. Alteration of type I interferon response is associated with subclinical atherosclerosis in virologically suppressed HIV-1-infected male patients. J Med Virol. 2021;93(8):4930-4938. doi: 10.1002/jmv.27028. IF 20, citations 5
32. Scagnolari C, Bitossi C, Viscido A, Frasca F, Oliveto G, Scordio M, Petrarca L, Mancino E, Nenna R, Riva E, De Vito C, Midulla F, Antonelli G, Pierangeli A. ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry? Cytokine. 2021;140:155430. doi: 10.1016/j.cyto.2021.155430. IF 3.9, , citations 11
33. Scagnolari C, Pierangeli A, Frasca F, Bitossi C, Viscido A, Oliveto G, Scordio M, Mazzuti L, Di Carlo D, Gentile M, Solimini A, Ceccarelli G, Pugliese F, Mastroianni CM, d'Ettorre G, Turriziani O, Antonelli G; Virology and Infectious Diseases COVID-19 Study Group of Sapienza University. Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19). Virus Res. 2021;295:198283. doi: 10.1016/j.virusres.2020.198283 IF 6.2, citations 23
34. Bitossi C, Frasca F, Viscido A, Oliveto G, Scordio M, Belloni L, Cimino G, Pietropaolo V, Gentile M, d'Ettorre G, Midulla F, Trancassini M, Antonelli G, Pierangeli A, Scagnolari C. SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients. Microorganisms. 2021;9(1):93. doi: 10.3390/microorganisms9010093. IF 4.9, citations 5
35. Upasani V, Scagnolari C, Frasca F, Smith N, Bondet V, Vanderlinden A, Lay S, Auerswald H, Heng S, Laurent D, Ly S, Duong V, Antonelli G, Dussart P, Duffy D, Cantaert T. Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue. Front Immunol. 2020;11:605087. doi: 10.3389/fimmu.2020.605087. IF 7.5, citations 10
36. Manica M, Riello S, Scagnolari C, Caputo B. Spatio-Temporal Distribution of Aedes Albopictus and Culex Pipiens along an Urban-Natural Gradient in the Ventotene Island, Italy. Int J Environ Res Public Health. 2020;17(22):8300. doi: 10.3390/ijerph17228300. IF 3.3, citations 4
37. Clementi N, Scagnolari C, D'Amore A, Palombi F, Criscuolo E, Frasca F, Pierangeli A, Mancini N, Antonelli G, Clementi M, Carpaneto A, Filippini A. Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro. Pharmacol Res. 2021;163:105255. doi: 10.1016/j.phrs.2020.105255. IF 10, citations 96
38. d'Ettorre G, Recchia G, Ridolfi M, Siccardi G, Pinacchio C, Innocenti GP, Santinelli L, Frasca F, Bitossi C, Ceccarelli G, Borrazzo C, Antonelli G, Scagnolari C, Mastroianni CM. Analysis of type I IFN response and T cell activation in severe COVID-19/HIV-1 coinfection: A case report. Medicine (Baltimore). 2020;99(36):e21803. doi: 10.1097/MD.0000000000021803. IF 1.8, citations 19
39. d'Ettorre G, Ceccarelli G, Marazzato M, Campagna G, Pinacchio C, Alessandri F, Ruberto F, Rossi G, Celani L, Scagnolari C, Mastropietro C, Trinchieri V, Recchia GE, Mauro V, Antonelli G, Pugliese F, Mastroianni CM. Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19. Front Med (Lausanne). 2020;7:389. doi: 10.3389/fmed.2020.00389. IF 5.0, citations 152
40. Scagnolari C, Bitossi C, Frasca F, Viscido A, Brazzini G, Trancassini M, Pietropaolo V, Midulla F, Cimino G, Palange P, Pierangeli A, Antonelli G. Differential toll like receptor expression in cystic fibrosis patients' airways during rhinovirus infection. J Infect. 2020 Nov;81(5):726-735. doi: 10.1016/j.jinf.2020.07.021. IF 6.0, citations 4
41. Pinacchio C, Scagnolari C, Iebba V, Santinelli L, Innocenti GP, Frasca F, Bitossi C, Scordio M, Oliveto G, Ceccarelli G, Antonelli G, Mastroianni CM, d'Ettorre G. High abundance of genus Prevotella is associated with dysregulation of IFN-I and T cell response in HIV-1-infected patients. AIDS. 2020;34(10):1467-1473. doi: 10.1097/QAD.0000000000002574. IF 4.1, citations 14
42. Ceccarelli G, Scagnolari C, Pugliese F, Mastroianni CM, d'Ettorre G. Probiotics and COVID-19. Lancet Gastroenterol Hepatol. 2020;5(8):721-722. doi: 10.1016/S2468-1253(20)30196-5. IF 18, citations 34
43. Innocenti GP, Santinelli L, Laghi L, Borrazzo C, Pinacchio C, Fratino M, Celani L, Cavallari EN, Scagnolari C, Frasca F, Antonelli G, Mastroianni CM, d'Ettorre G, Ceccarelli G. Modulation of Phenylalanine and Tyrosine Metabolism in HIV-1 Infected Patients with Neurocognitive Impairment: Results from a Clinical Trial. Metabolites. 2020;10(7):274. doi: 10.3390/metabo10070274. IF 4.9, citations 6
44. Scagnolari C, Bitossi C, Frasca F, Viscido A, Oliveto G, Scordio M, De Vito C, Trancassini M, Midulla F, Cimino G, Pierangeli A, Antonelli G. No detection of SARS-CoV-2 in cystic fibrosis patients at the Regional (Lazio) Reference Center for CF in Italy. J Cyst Fibros. 2020;19(5):837-838. doi: 10.1016/j.jcf.2020.06.018. IF 5.4, citations 9
45. Clementi N, Ferrarese R, Criscuolo E, Diotti RA, Castelli M, Scagnolari C, Burioni R, Antonelli G, Clementi M, Mancini N. Interferon-β-1a Inhibition of Severe Acute Respiratory Syndrome-Coronavirus 2 In Vitro When Administered After Virus Infection. J Infect Dis. 2020;222(5):722-725. doi: 10.1093/infdis/jiaa350. IF 5.2, citations 50
46. Caputo B, Russo G, Manica M, Vairo F, Poletti P, Guzzetta G, Merler S, Scagnolari C, Solimini A. A comparative analysis of the 2007 and 2017 Italian chikungunya outbreaks and implication for public health response. PLoS Negl Trop Dis. 2020;14(6):e0008159. doi: 10.1371/journal.pntd.0008159. IF 4.4, citations 19
47. Antonelli G, Turriziani O, Pierangeli A, d'Ettorre G, Galardo G, Pugliese F, Mastroianni CM, Scagnolari C. Type I interferons can be detected in respiratory swabs from SARS-Cov-2 infected patients. J Clin Virol. 2020;128:104450. doi: 10.1016/j.jcv.2020.104450. IF 3.1, citations 9
48. Mancino E, Cristiani L, Pierangeli A, Scagnolari C, Nenna R, Petrarca L, Di Mattia G, La Regina D, Frassanito A, Oliveto G, Viscido A, Midulla F. A single centre study of viral community-acquired pneumonia in children: No evidence of SARS-CoV-2 from October 2019 to March 2020. J Clin Virol. 2020;128:104385. doi: 10.1016/j.jcv.2020.104385. IF 3.1, citations 6
49. Scagnolari C, Cannella F, Pierangeli A, Mellinger Pilgrim R, Antonelli G, Rowley D, Wong M, Best S, Xing D, Roden RBS, Viscidi R. Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice. J Virol. 2020;94(12):e00087-20. doi: 10.1128/JVI.00087-20. IF 5.1, citations 13
50. Cristiani L, Mancino E, Matera L, Nenna R, Pierangeli A, Scagnolari C, Midulla F. Will children reveal their secret? The coronavirus dilemma. Eur Respir J. 2020;55(4):2000749. doi: 10.1183/13993003.00749-2020. IF 16, citations 121
51. Di Pietro M, Filardo S, Frasca F, Scagnolari C, Manera M, Sessa V, Antonelli G, Sessa R. Interferon-γ Possesses Anti-Microbial and Immunomodulatory Activity on a Chlamydia Trachomatis Infection Model of Primary Human Synovial Fibroblasts. Microorganisms. 2020;8(2):235. doi: 10.3390/microorganisms8020235. IF 4.1, citations 6
52. Midulla F, Di Mattia G, Nenna R, Scagnolari C, Viscido A, Oliveto G, Petrarca L, Frassanito A, Arima S, Antonelli G, Pierangeli A. Novel Variants of Respiratory Syncytial Virus A ON1 Associated With Increased Clinical Severity of Bronchiolitis. J Infect Dis. 2020;222(1):102-110. doi: 10.1093/infdis/jiaa059. IF 5.2, citations 22
53. Nenna R, Fedele G, Frassanito A, Petrarca L, Di Mattia G, Pierangeli A, Scagnolari C, Papoff P, Schiavoni I, Leone P, Moretti C, Midulla F. Increased T-helper Cell 2 Response in Infants With Respiratory Syncytial Virus Bronchiolitis Hospitalized Outside Epidemic Peak. Pediatr Infect Dis J. 2020;39(1):61-67. doi: 10.1097/INF.0000000000002505. IF 2.1, citations 7
54. Petrarca L, Nenna R, Frassanito A, Pierangeli A, Di Mattia G, Scagnolari C, Midulla F. Human bocavirus in children hospitalized for acute respiratory tract infection in Rome. World J Pediatr. 2020;16(3):293-298. doi: 10.1007/s12519-019-00324-5. IF 2.7, citations 33
55. Landi C, Santinelli L, Bianchi L, Shaba E, Ceccarelli G, Cavallari EN, Borrazzo C, Pinacchio C, Scagnolari C, Vullo V, Bini L, d'Ettorre G. Cognitive impairment and CSF proteome modification after oral bacteriotherapy in HIV patients. J Neurovirol. 2020;26(1):95-106. doi: 10.1007/s13365-019-00801-7. IF 2.6, citations 6
56. Pierangeli A, Viscido A, Bitossi C, Frasca F, Gentile M, Oliveto G, Frassanito A, Nenna R, Midulla F, Scagnolari C. Differential interferon gene expression in bronchiolitis caused by respiratory syncytial virus-A genotype ON1. Med Microbiol Immunol. 2020;209(1):23-28. doi: 10.1007/s00430-019-00633-6. IF 3.4, citations 12
57. Falasca F, Cavallari EN, Innocenti GP, Scagnolari C, Mezzaroma I, Santinelli L, Ceccarelli G, Vullo V, Turriziani O, d'Ettorre G. Antiviral Activity of Fecal Water Samples from HIV-1 Infected Subjects Treated with a Specific Probiotic Formulation. Curr HIV Res. 2019;17(3):183-189. doi: 10.2174/1570162X17666190903230622. IF 0.8, citations 0
58. Ceccarelli G, Statzu M, Santinelli L, Pinacchio C, Bitossi C, Cavallari EN, Vullo V, Scagnolari C, d'Ettorre G. Challenges in the management of HIV infection: update on the role of probiotic supplementation as a possible complementary therapeutic strategy for cART treated people living with HIV/AIDS. Expert Opin Biol Ther. 2019;19(9):949-965. doi: 10.1080/14712598.2019.1638907. IF 3.2, citations 27
59. De Angelis M, Scagnolari C, Oliva A, Cavallari EN, Celani L, Santinelli L, Innocenti GP, Borrazzo C, Ceccarelli G, Vullo V, d'Ettorre G. Short-Term Probiotic Administration Increases Fecal-Anti Candida Activity in Healthy Subjects. Microorganisms. 2019 Jun 3;7(6):162. doi: 10.3390/microorganisms7060162. IF 4.1, citations 7
60. Santinelli L, Statzu M, Pierangeli A, Frasca F, Bressan A, Pinacchio C, Nonne C, Turriziani O, Antonelli G, d'Ettorre G, Scagnolari C. Increased expression of IL-32 correlates with IFN-γ, Th1 and Tc1 in virologically suppressed HIV-1-infected patients. Cytokine. 2019;120:273-281. doi: 10.1016/j.cyto.2019.01.012. IF 2.9, citations 12
61. d'Ettorre G, Borrazzo C, Pinacchio C, Santinelli L, Cavallari EN, Statzu M, Fanello G, Ceccarelli G, Antonelli G, Vullo V, Mastroianni CM, Scagnolari C. Increased IL-17 and/or IFN-γ producing T-cell subsets in gut mucosa of long-term-treated HIV-1-infected women. AIDS. 2019 Mar 15;33(4):627-636. doi: 10.1097/QAD.0000000000002122. IF 4.5, citations 6
62. Statzu M, Santinelli L, Viscido A, Pinacchio C, Ceccarelli G, Rotondo C, Corano Scheri G, Mezzaroma I, Turriziani O, Antonelli G, d'Ettorre G, Scagnolari C. Increased SAMHD1 transcript expression correlates with interferon-related genes in HIV-1-infected patients. Med Microbiol Immunol. 2019 Oct;208(5):679-691. doi: 10.1007/s00430-018-0574-x. IF 1.9, citations 7
63. Midulla F, Nenna R, Scagnolari C, Petrarca L, Frassanito A, Viscido A, Arima S, Antonelli G, Pierangeli A. How Respiratory Syncytial Virus Genotypes Influence the Clinical Course in Infants Hospitalized for Bronchiolitis. J Infect Dis. 2019;219(4):526-534. doi: 10.1093/infdis/jiy496. IF 5.0, citations 47
64. Maggi F, Focosi D, Statzu M, Bianco G, Costa C, Macera L, Spezia PG, Medici C, Albert E, Navarro D, Scagnolari C, Pistello M, Cavallo R, Antonelli G. Early Post-Transplant Torquetenovirus Viremia Predicts Cytomegalovirus Reactivations in Solid Organ Transplant Recipients. Sci Rep. 2018 Oct 19;8(1):15490. doi: 10.1038/s41598-018-33909-7. IF 4.0, citations 59
65. Pierangeli A, Scagnolari C, Antonelli G. Respiratory syncytial virus. Minerva Pediatr. 2018;70(6):553-565. doi: 10.23736/S0026-4946.18.05312-4. Review. IF 0.8, citations 24
66. Pinacchio C, Scheri GC, Statzu M, Santinelli L, Ceccarelli G, Innocenti GP, Vullo V, Antonelli G, Brenchley JM, d'Ettorre G, Scagnolari C. Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation. J Immunol Res. 2018; 2018:1738676. doi: 10.1155/2018/1738676. IF 3.4, citations 15
67. Annibali O, Piccioni L, Tomarchio V, Circhetta E, Sarlo C, Franceschini L, Cantonetti M, Rizzo E, Angeletti S, Tirindelli MC, Scagnolari C, Statzu M, Avvisati G, Riva E. Impact of IFN lambda 3/4 single nucleotide polymorphisms on the cytomegalovirus reactivation in autologous stem cell transplant patients. PLoS One. 2018;13(7):e0200221. doi: 10.1371/journal.pone.0200221. IF 2.7, citations 7
68. Fedele G, Schiavoni I, Nenna R, Pierangeli A, Frassanito A, Leone P, Petrarca L, Scagnolari C, Midulla F. Analysis of the immune response in infants hospitalized with viral bronchiolitis shows different Th1/Th2 profiles associated with respiratory syncytial virus and human rhinovirus. Pediatr Allergy Immunol. 2018;29(5):555-557. doi: 10.1111/pai.12919. IF 4.6, citations 24
69. Scagnolari C, Antonelli G. Type I interferon and HIV: Subtle balance between antiviral activity, immunopathogenesis and the microbiome. Cytokine Growth Factor Rev. 2018;40:19-31. doi: 10.1016/j.cytogfr.2018.03.003. IF 5.4, citations 28
70. Pierangeli A, Statzu M, Nenna R, Santinelli L, Petrarca L, Frassanito A, Gentile M, Antonelli G, Midulla F, Scagnolari C. Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity. J Clin Virol. 2018;102:101-109. doi: 10.1016/j.jcv.2018.03.003. IF 3.0, citations 19
71. Najafi Fard S, Schietroma I, Corano Scheri G, Giustini N, Serafino S, Cavallari EN, Pinacchio C, De Girolamo G, Ceccarelli G, Scagnolari C, Vullo V, d'Ettorre G. Direct-acting antiviral therapy enhances total CD4+ and CD8+ T-cells responses, but does not alter T-cells activation among HCV mono-infected, and HCV/HIV-1 co-infected patients. Clin Res Hepatol Gastroenterol. 2018;42(4):319-329. doi: 10.1016/j.clinre.2017.11.006. IF 2.8, citations 25
72. Cannella F, Scagnolari C, Statzu M, Sciandra I, Recine N, d'Ettorre G, Antonelli G, Pierangeli A. Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome. Virus Genes. 2018;54(2):319-322. doi: 10.1007/s11262-017-1527-y. IF 1.6, citations 2
73. Petrarca L, Nenna R, Frassanito A, Pierangeli A, Leonardi S, Scagnolari C, Antonelli G, Papoff P, Moretti C, Midulla F. Acute bronchiolitis: Influence of viral co-infection in infants hospitalized over 12 consecutive epidemic seasons. J Med Virol. 2018 Apr;90(4):631-638. doi: 10.1002/jmv.24994. IF 2.0, citations 44
74. Schiavoni I, Scagnolari C, Horenstein AL, Leone P, Pierangeli A, Malavasi F, Ausiello CM, Fedele G. CD38 modulates respiratory syncytial virus-driven proinflammatory processes in human monocyte-derived dendritic cells. Immunology. 2018;154(1):122-131. doi: 10.1111/imm.12873. IF 4.1, citations 26
75. Ceccarelli G, Brenchley JM, Cavallari EN, Scheri GC, Fratino M, Pinacchio C, Schietroma I, Fard SN, Scagnolari C, Mezzaroma I, Vullo V, d'Ettorre G. Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals. Nutrients. 2017;9(11):1269. doi: 10.3390/nu9111269. IF 4.1, citations 38
76. Ceccarelli G, Fratino M, Selvaggi C, Giustini N, Serafino S, Schietroma I, Corano Scheri G, Pavone P, Passavanti G, Alunni Fegatelli D, Mezzaroma I, Antonelli G, Vullo V, Scagnolari C, d'Ettorre G. A pilot study on the effects of probiotic supplementation on neuropsychological performance and microRNA-29a-c levels in antiretroviral-treated HIV-1-infected patients. Brain Behav. 2017;7(8):e00756. doi: 10.1002/brb3.756. IF 2.2, citations 41
77. Nenna R, Evangelisti M, Frassanito A, Scagnolari C, Pierangeli A, Antonelli G, Nicolai A, Arima S, Moretti C, Papoff P, Villa MP, Midulla F. Respiratory syncytial virus bronchiolitis, weather conditions and air pollution in an Italian urban area: An observational study. Environ Res. 2017;158:188-193. doi: 10.1016/j.envres.2017.06.014. IF 4.7, citations 83
78. d'Ettorre G, Rossi G, Scagnolari C, Andreotti M, Giustini N, Serafino S, Schietroma I, Scheri GC, Fard SN, Trinchieri V, Mastromarino P, Selvaggi C, Scarpona S, Fanello G, Fiocca F, Ceccarelli G, Antonelli G, Brenchley JM, Vullo V. Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitochondrial morphology in ART-treated HIV-1-positive patients. Immun Inflamm Dis. 2017;5(3):244-260. doi: 10.1002/iid3.160. IF: NA (NOT APPPLICBLE) , citations 79
79. Scagnolari C, Midulla F, Nenna R, Papoff P, Antonelli G, Pierangeli A. Rhinovirus species/genotypes and interferon-λ: subtypes, receptor and polymorphisms - missing pieces of the puzzle of childhood asthma? Eur Respir J. 2017;49(3):1700060. doi: 10.1183/13993003.00060-2017. IF 12, citations 0
80. Scagnolari C, Caputo B, Rezza G, Antonelli G. Antiviral Activity of the Combination of Interferon and Ribavirin Against Chikungunya Virus: Are the Results Conclusive? J Infect Dis. 2017;215(3):492-493. doi: 10.1093/infdis/jiw579. IF 5.1, citations 5
81. Scagnolari C, Turriziani O, Monteleone K, Pierangeli A, Antonelli G. Consolidation of molecular testing in clinical virology. Expert Rev Anti Infect Ther. 2017;15(4):387-400. doi: 10.1080/14787210.2017.1271711. Review. IF 3.1, citations 12
82. Nicolai A, Frassanito A, Nenna R, Cangiano G, Petrarca L, Papoff P, Pierangeli A, Scagnolari C, Moretti C, Midulla F. Risk Factors for Virus-induced Acute Respiratory Tract Infections in Children Younger Than 3 Years and Recurrent Wheezing at 36 Months Follow-Up After Discharge. Pediatr Infect Dis J. 2017 Feb;36(2):179-183. doi: 10.1097/INF.0000000000001385. IF 2.3, citations 35
83. Scagnolari C, Corano Scheri G, Selvaggi C, Schietroma I, Najafi Fard S, Mastrangelo A, Giustini N, Serafino S, Pinacchio C, Pavone P, Fanello G, Ceccarelli G, Vullo V, d'Ettorre G. Probiotics Differently Affect Gut-Associated Lymphoid Tissue Indolamine-2,3-Dioxygenase mRNA and Cerebrospinal Fluid Neopterin Levels in Antiretroviral-Treated HIV-1 Infected Patients: A Pilot Study. Int J Mol Sci. 2016;17(10):1639. doi: 10.3390/ijms17101639. IF 3.2, citations 19
84. Monteleone K, Scheri GC, Statzu M, Selvaggi C, Falasca F, Giustini N, Mezzaroma I, Turriziani O, d'Ettorre G, Antonelli G, Scagnolari C. IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection. Arch Virol. 2016;161(11):3263-8. doi: 10.1007/s00705-016-3016-3. IF 2.0, citations 3
85. Cangiano G, Nenna R, Frassanito A, Evangelisti M, Nicolai A, Scagnolari C, Pierangeli A, Antonelli G, Papoff P, Petrarca L, Capocaccia P, Moretti C, Midulla F. Bronchiolitis: Analysis of 10 consecutive epidemic seasons. Pediatr Pulmonol. 2016 Dec;51(12):1330-1335. doi: 10.1002/ppul.23476. IF 2.7, citations 47
86. Scagnolari C, Monteleone K, Cacciotti G, Antonelli G. Role of Interferons in Chronic Hepatitis C Infection. Curr Drug Targets. 2017;18(7):844-850. doi: 10.2174/1389450117666160201112632. IF 3.2, citations 13
87. Scagnolari C, Monteleone K, Selvaggi C, Pierangeli A, D'Ettorre G, Mezzaroma I, Turriziani O, Gentile M, Vullo V, Antonelli G. ISG15 expression correlates with HIV-1 viral load and with factors regulating T cell response. Immunobiology. 2016;221(2):282-90. doi: 10.1016/j.imbio.2015.10.007. IF 2.7, citations 29
88. Pierangeli A, Cannella F, Scagnolari C, Gentile M, Sciandra I, Antonelli G, Ciolfi C, Russo C, Palaia G, Romeo U, Polimeni A. Frequent detection of high human papillomavirus DNA loads in oral potentially malignant disorders. Clin Microbiol Infect. 2016;22(1):95.e9-95.e15. doi: 10.1016/j.cmi.2015.09.011. IF 5.2, citations 17
89. Cacciotti G, Caputo B, Selvaggi C, la Sala A, Vitiello L, Diallo D, Ceianu C, Antonelli G, Nowotny N, Scagnolari C. Variation in interferon sensitivity and induction between Usutu and West Nile (lineages 1 and 2) viruses. Virology. 2015;485:189-98. doi: 10.1016/j.virol.2015.07.015. IF 3.2, citations 20
90. d'Ettorre G, Ceccarelli G, Andreotti M, Selvaggi C, Giustini N, Serafino S, Schietroma I, Nunnari G, Antonelli G, Vullo V, Scagnolari C. Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients. Mediators Inflamm. 2015;2015:395484. doi: 10.1155/2015/395484. IF 3.4, citations 22
91. Nenna R, Ferrara M, Nicolai A, Pierangeli A, Scagnolari C, Papoff P, Antonelli G, Moretti C, Midulla F. Viral Load in Infants Hospitalized for Respiratory Syncytial Virus Bronchiolitis Correlates with Recurrent Wheezing at Thirty-Six-Month Follow-Up. Pediatr Infect Dis J. 2015;34(10):1131-2. doi: 10.1097/INF.0000000000000825. IF 2.5, citations 21
92. Giacomini E, Severa M, Cruciani M, Etna MP, Rizzo F, Pardini M, Scagnolari C, Garaci E, Coccia EM. Dual effect of Thymosin α 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists. Expert Opin Biol Ther. 2015;15 Suppl 1:S59-70. doi: 10.1517/14712598.2015.1019460. IF 3.4, citations 17
93. Monteleone K, Selvaggi C, Cacciotti G, Falasca F, Mezzaroma I, D'Ettorre G, Turriziani O, Vullo V, Antonelli G, Scagnolari C. MicroRNA-29 family expression and its relation to antiviral immune response and viro-immunological markers in HIV-1-infected patients. BMC Infect Dis. 2015;15:51. doi: 10.1186/s12879-015-0768-4. IF 2.6, citations 26
94. Maggi F, Mazzetti P, Focosi D, Macera L, Scagnolari C, Manzin A, Antonelli G, Nelli LC. Lack of usutu virus RNA in cerebrospinal fluid of patients with encephalitis of unknown etiology, Tuscany, Italy. J Med Virol. 2015 Jun;87(6):913-6. doi: 10.1002/jmv.24149. IF 1.9, citations 5
95. Antonelli G, Scagnolari C, Moschella F, Proietti E. Twenty-five years of type I interferon-based treatment: a critical analysis of its therapeutic use. Cytokine Growth Factor Rev. 2015;26(2):121-31. doi: 10.1016/j.cytogfr.2014.12.006. Review. IF 6.5, citations 44
96. Cannella F, Pierangeli A, Scagnolari C, Cacciotti G, Tranquilli G, Stentella P, Recine N, Antonelli G. TLR9 is expressed in human papillomavirus-positive cervical cells and is overexpressed in persistent infections. Immunobiology. 2015;220(3):363-8. doi: 10.1016/j.imbio.2014.10.012. IF 2.7, citations 42
97. Cuomo L, Cirone M, Di Gregorio AO, Vitillo M, Cattivelli M, Magliocca V, Maiorano S, Meledandri M, Scagnolari C, La Rocca S, Trivedi P. Elevated antinuclear antibodies and altered anti-Epstein-Barr virus immune responses. Virus Res. 2015;195:95-9. doi: 10.1016/j.virusres.2014.09.014. IF 2.5, citations 13
98. Riva E, Scagnolari C, Turriziani O, Antonelli G. Hepatitis C virus and interferon type III (interferon-λ3/interleukin-28B and interferon-λ4): genetic basis of susceptibility to infection and response to antiviral treatment. Clin Microbiol Infect. 2014;20(12):1237-45. doi: 10.1111/1469-0691.12797. Review. IF 5.7, citations 18
99. Pierangeli A, Trotta D, Scagnolari C, Ferreri ML, Nicolai A, Midulla F, Marinelli K, Antonelli G, Bagnarelli P. Rapid spread of the novel respiratory syncytial virus A ON1 genotype, central Italy, 2011 to 2013. Euro Surveill. 2014;19(26):20843. doi: 10.2807/1560-7917.es2014.19.26.20843. IF 5.7, citations 70
100. Midulla F, Nicolai A, Ferrara M, Gentile F, Pierangeli A, Bonci E, Scagnolari C, Moretti C, Antonelli G, Papoff P. Recurrent wheezing 36 months after bronchiolitis is associated with rhinovirus infections and blood eosinophilia. Acta Paediatr. 2014;103(10):1094-9. doi: 10.1111/apa.12720. IF 1.6, citations 51
101. Scagnolari C, Selvaggi C, Di Biase E, Fraulo M, Dangond F, Antonelli G. In vitro assessment of the biologic activity of interferon beta formulations used for the treatment of relapsing multiple sclerosis. J Immunoassay Immunochem. 2014;35(3):288-99. doi: 10.1080/15321819.2013.848815. IF 0.7, citations 7
102. Monteleone K, Di Maio P, Cacciotti G, Falasca F, Fraulo M, Falciano M, Mezzaroma I, D'Ettorre G, Turriziani O, Scagnolari C. Interleukin-32 isoforms: expression, interaction with interferon-regulated genes and clinical significance in chronically HIV-1-infected patients. Med Microbiol Immunol. 2014 Jun;203(3):207-16. doi: 10.1007/s00430-014-0329-2. IF 3.0, citations 22
103. Cannella F, Scagnolari C, Selvaggi C, Stentella P, Recine N, Antonelli G, Pierangeli A. Interferon lambda 1 expression in cervical cells differs between low-risk and high-risk human papillomavirus-positive women. Med Microbiol Immunol. 2014;203(3):177-84. doi: 10.1007/s00430-014-0330-9. IF 3.0, citations 27
104. Selvaggi C, Pierangeli A, Fabiani M, Spano L, Nicolai A, Papoff P, Moretti C, Midulla F, Antonelli G, Scagnolari C. Interferon lambda 1-3 expression in infants hospitalized for RSV or HRV associated bronchiolitis. J Infect. 2014;68(5):467-77. doi: 10.1016/j.jinf.2013.12.010. IF 4.4, citations 57
105. Nicolai A, Nenna R, Stefanelli P, Carannante A, Schiavariello C, Pierangeli A, Scagnolari C, Moretti C, Papoff P, Bonci E, Ferrara M, Papasso S, Midulla F. Bordetella pertussis in infants hospitalized for acute respiratory symptoms remains a concern. BMC Infect Dis. 2013;13:526. doi: 10.1186/1471-2334-13-526. IF 2.5, citations 24
106. Pierangeli A, Ciccozzi M, Chiavelli S, Concato C, Giovanetti M, Cella E, Spano L, Scagnolari C, Moretti C, Papoff P, Muraca M, Midulla F, Antonelli G. Molecular epidemiology and genetic diversity of human rhinovirus affecting hospitalized children in Rome. Med Microbiol Immunol. 2013 Aug;202(4):303-11. doi: 10.1007/s00430-013-0296-z. IF 2.4, citations 22
107. Scagnolari C, Antonelli G. Antiviral activity of the interferon α family: biological and pharmacological aspects of the treatment of chronic hepatitis C. Expert Opin Biol Ther. 2013 May;13(5):693-711. doi: 10.1517/14712598.2013.764409. IF 3.6, citations 23
108. Scagnolari C, Caputo B, Trombetti S, Cacciotti G, Soldà A, Spano L, Villari P, Della Torre A, Nowotny N, Antonelli G. Usutu virus growth in human cell lines: induction of and sensitivity to type I and III interferons. J Gen Virol. 2013 Apr;94(Pt 4):789-795. doi: 10.1099/vir.0.046433-0. IF 3.5, citations 17
109. Riva E, Scagnolari C, Monteleone K, Selvaggi C, Picardi A, Mazzarelli C, Pizzigallo E, Vincenzi B, Carducci A, Antonaci S, Giannelli G, Antonelli G. Interleukin-28B (IL-28B) single-nucleotide polymorphisms and interferon plus ribavirin treatment outcome in Italian chronically HCV-infected patients. J Viral Hepat. 2012; 19(9):650-3. doi: 10.1111/j.1365-2893.2012.01606.x. IF 3.0, citations 10
110. Pierangeli A, Scagnolari C, Selvaggi C, Cannella F, Riva E, Impagnatiello A, Bernardi G, Ciardi A, Moschella CM, Antonelli G, Indinnimeo M. High detection rate of human papillomavirus in anal brushings from women attending a proctology clinic. J Infect. 2012 Sep;65(3):255-61. doi: 10.1016/j.jinf.2012.05.004. IF 4.0, citations 6
111. Scagnolari C, Midulla F, Selvaggi C, Monteleone K, Bonci E, Papoff P, Cangiano G, Di Marco P, Moretti C, Pierangeli A, Antonelli G. Evaluation of viral load in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. Med Microbiol Immunol. 2012 Aug;201(3):311-7. doi: 10.1007/s00430-012-0233-6. IF 3.5, citations 49
112. Visentini M, Conti V, Cagliuso M, Siciliano G, Scagnolari C, Casato M, Fiorilli M. Persistence of a large population of exhausted monoclonal B cells in mixed cryoglobuliemia after the eradication of hepatitis C virus infection. J Clin Immunol. 2012 Aug;32(4):729-35. doi: 10.1007/s10875-012-9677-0. IF 3.3, citations 18
113. Scagnolari C, Midulla F, Riva E, Monteleone K, Solimini A, Bonci E, Cangiano G, Papoff P, Moretti C, Pierangeli A, Antonelli G. Evaluation of interleukin 28B single nucleotide polymorphisms in infants suffering from bronchiolitis. Virus Res. 2012 May;165(2):236-40. doi: 10.1016/j.virusres.2012.02.018. IF 2.7, citations 12
114. Scagnolari C, Trombetti S, Soldà A, Milella M, Gaeta GB, Angarano G, Scotto G, Caporaso N, Morisco F, Cozzolongo R, Giannelli G, Fasano M, Santantonio T, Antonelli G. Development and specificities of anti-interferon neutralizing antibodies in patients with chronic hepatitis C treated with pegylated interferon-α. Clin Microbiol Infect. 2012 Oct;18(10):1033-9. doi: 10.1111/j.1469-0691.2011.03729.x. IF 4.5, citations 12
115. Pierangeli A, Scagnolari C, Selvaggi C, Monteleone K, Verzaro S, Nenna R, Cangiano G, Moretti C, Papoff P, Antonelli G, Midulla F. Virological and clinical characterization of respiratory infections in children attending an emergency department during the first autumn-winter circulation of pandemic A (H1N1) 2009 influenza virus. Clin Microbiol Infect. 2012;18(4):366-73. doi: 10.1111/j.1469-0691.2011.03590.x. IF 4.5, citations 16
116. Midulla F, Pierangeli A, Cangiano G, Bonci E, Salvadei S, Scagnolari C, Moretti C, Antonelli G, Ferro V, Papoff P. Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up. Eur Respir J. 2012;39(2):396-402. doi: 10.1183/09031936.00188210. IF 6.3, citations 105
117. Nenna R, Papoff P, Moretti C, Pierangeli A, Sabatino G, Costantino F, Soscia F, Cangiano G, Ferro V, Mennini M, Salvadei S, Scagnolari C, Antonelli G, Midulla F. Detection of respiratory viruses in the 2009 winter season in Rome: 2009 influenza A (H1N1) complications in children and concomitant type 1 diabetes onset. Int J Immunopathol Pharmacol. 2011;24(3):651-9. doi: 10.1177/039463201102400311. IF 2.9, citations 42
118. Pierangeli A, Scagnolari C, Selvaggi C, Verzaro S, Spina MT, Bresciani E, Antonelli G, Bertazzoni G. Rhinovirus frequently detected in elderly adults attending an emergency department. J Med Virol. 2011;83(11):2043-7. doi: 10.1002/jmv.22205. IF 2.8, citations 17
119. Pierangeli A, Degener AM, Ferreri ML, Riva E, Rizzo B, Turriziani O, Luciani S, Scagnolari C, Antonelli G. Interferon-induced gene expression in cervical mucosa during human papillomavirus infection. Int J Immunopathol Pharmacol. 2011;24(1):217-23. doi: 10.1177/039463201102400126. IF 2.9, citations 16
120. Scagnolari C, Trombetti S, Selvaggi C, Carbone T, Monteleone K, Spano L, Di Marco P, Pierangeli A, Maggi F, Riva E, Antonelli G. In vitro sensitivity of human metapneumovirus to type I interferons. Viral Immunol. 2011 Apr;24(2):159-64. doi: 10.1089/vim.2010.0073. IF 1.9, citations 9
121. Papoff P, Moretti C, Cangiano G, Bonci E, Roggini M, Pierangeli A, Scagnolari C, Antonelli G, Midulla F. Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis. Acta Paediatr. 2011;100(7):e17-23. doi: 10.1111/j.1651-2227.2011.02181.x. IF 2.0, citations 50
122. Scagnolari C, Trombetti S, Soldà A, Selvaggi C, Monteleone K, Spano L, Pierangeli A, Clementi M, Turriziani O, Antonelli G. Pandemic 2009 H1N1 influenza virus is resistant to the antiviral activity of several interferon alpha subtypes. J Interferon Cytokine Res. 2011;31(6):475-9. doi: 10.1089/jir.2010.0125. IF. 3.0, citations 19
123. De Rossi A, Zanchetta M, Vitone F, Antonelli G, Bagnarelli P, Buonaguro L, Capobianchi MR, Clementi M, Abbate I, Canducci F, Monachetti A, Riva E, Rozera G, Scagnolari C, Tagliamonte M, Re MC; SIVIM (Italian Society of Medical Virology) Group. Quantitative HIV-1 proviral DNA detection: a multicentre analysis. New Microbiol. 2010;33(4):293-302. IF 0.6, citations 15
124. Scagnolari C, Zingariello P, Vecchiet J, Selvaggi C, Racciatti D, Taliani G, Riva E, Pizzigallo E, Antonelli G. Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha. Virol J. 2010;7:311. doi: 10.1186/1743-422X-7-311. IF 2.5, citations 55
125. Pierangeli A, Scagnolari C, Gentile M, Spina MT, Iudicello A, Bertazzoni G, Antonelli G. Virological diagnosis of respiratory virus infection in patients attending an emergency department during the influenza season. Clin Microbiol Infect. 2010, 16(4):391-3. doi: 10.1111/j.1469-0691.2009.03119.x. IF 4.7, citations 6
126. Midulla F, Scagnolari C, Bonci E, Pierangeli A, Antonelli G, De Angelis D, Berardi R, Moretti C. Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants. Arch Dis Child. 2010;95(1):35-41. doi: 10.1136/adc.2008.153361. IF 2.6, citations 173
127. Scagnolari C, Selvaggi C, Chiavuzzo L, Carbone T, Zaffiri L, d'Ettorre G, Girardi E, Turriziani O, Vullo V, Antonelli G. Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1-infected patients failing antiretroviral therapy. Intervirology. 2009;52(2):107-14. doi: 10.1159/000218082 IF 1.1, citations 20
128. Scagnolari C, Midulla F, Pierangeli A, Moretti C, Bonci E, Berardi R, De Angelis D, Selvaggi C, Di Marco P, Girardi E, Antonelli G. Gene expression of nucleic acid-sensing pattern recognition receptors in children hospitalized for respiratory syncytial virus-associated acute bronchiolitis. Clin Vaccine Immunol. 2009;16(6):816-23. doi: 10.1128/CVI.00445-08. IF 2.3, citations 51
129. Bellomi F, Bramanti P, Trojano M, Scagnolari C, Muto A, Sessa E, La Volpe V, Russo P, Antonelli G. Neutralizing and binding antibodies to interferon beta in patients with multiple sclerosis: a comparison of assay results from three italian centres. J Immunoassay Immunochem. 2009;30(1):40-50. doi: 10.1080/15321810802569857. IF 0.5, citations 6
130. Riva E, Maggi F, Abbruzzese F, Bellomi F, Giannelli G, Picardi A, Scagnolari C, Folgori A, Spada E, Piccolella E, Dianzani F, Antonelli G; Acute Hepatitis C Italian Study Group. Immune complexed (IC) hepatitis C virus (HCV) in chronically and acutely HCV-infected patients. Med Microbiol Immunol. 2009;198(1):13-8. doi: 10.1007/s00430-008-0099-9. IF 3.7, citations 5
131. Pierangeli A, Scagnolari C, Trombetti S, Grossi R, Battaglia M, Moretti C, Midulla F, Antonelli G. Human bocavirus infection in hospitalized children in Italy. Influenza Other Respir Viruses. 2008; 2(5):175-9. doi: 10.1111/j.1750-2659.2008.00057.x. IF NA, citations 28
132. Pierangeli A, Scagnolari C, Degener AM, Bucci M, Ciardi A, Riva E, Indinnimeo M, Mancini G, D'Ettorre G, Vullo V, Antonelli G. Type-specific human papillomavirus-DNA load in anal infection in HIV-positive men. AIDS. 2008;22(15):1929-35. doi: 10.1097/QAD.0b013e32830fbd7a. IF 5.4, citations 29
133. Scagnolari C, Trombetti S, Cicetti S, Antonelli S, Selvaggi C, Perrone L, Visca M, Romano S, Antonelli G. Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses. Intervirology. 2008;51(4):217-23. doi: 10.1159/000154258. IF 1.4, citations 8
134. Scagnolari C, Midulla F, Trombetti S, Pierangeli A, Tromba V, Grossi R, Di Marco P, Dianzani C, Girardi E, Antonelli G. Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis. Exp Biol Med (Maywood). 2007;232(10):1355-9. doi: 10.3181/0705-BC-124. IF 1.9, citations 14
135. Bruno R, Sacchi P, Scagnolari C, Torriani F, Maiocchi L, Patruno S, Bellomi F, Filice G, Antonelli G. Pharmacodynamics of peginterferon alpha-2a and peginterferon alpha-2b in interferon-naïve patients with chronic hepatitis C: a randomized, controlled study. Aliment Pharmacol Ther. 2007;26(3):369-76. doi: 10.1111/j.1365-2036.2007.03392.x. IF NA, citations 37
136. Scagnolari C, Duda P, Bagnato F, De Vito G, Alberelli A, Lavolpe V, Girardi E, Durastanti V, Trojano M, Kappos L, Antonelli G. Pharmacodynamics of interferon beta in multiple sclerosis patients with or without serum neutralizing antibodies. J Neurol. 2007;254(5):597-604. doi: 10.1007/s00415-006-0332-7. IF 2.4, citations 23
137. Pierangeli A, Gentile M, Di Marco P, Pagnotti P, Scagnolari C, Trombetti S, Lo Russo L, Tromba V, Moretti C, Midulla F, Antonelli G. Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, Italy. J Med Virol. 2007;79(4):463-8. doi: 10.1002/jmv.20832. IF 2.8, citations 120
138. Turriziani O, Bucci M, Stano A, Scagnolari C, Bellomi F, Fimiani C, Mezzaroma I, D'Ettorre G, Brogi A, Vullo V, Antonelli G. Genotypic resistance of archived and circulating viral strains in the blood of treated HIV-infected individuals. J Acquir Immune Defic Syndr. 2007;44(5):518-24. doi: 10.1097/QAI.0b013e3180315515. IF 4.4, citations 34
139. Scagnolari C, Bellomi F, Trombetti S, Casato M, Carlesimo M, Bagnato F, Lavolpe V, Bruno R, Millefiorini E, Antonelli L, Girardi E, Turriziani O, Antonelli G. Expression of biomarkers of interferon type I in patients suffering from chronic diseases. Clin Exp Immunol. 2007;147(2):270-6. doi: 10.1111/j.1365-2249.2006.03280.x. IF 2.5, citations 16
140. Scagnolari C, Trombetti S, Alberelli A, Cicetti S, Bellarosa D, Longo R, Spanò A, Riva E, Clementi M, Antonelli G. The synergistic interaction of interferon types I and II leads to marked reduction in severe acute respiratory syndrome-associated coronavirus replication and increase in the expression of mRNAs for interferon-induced proteins. Intervirology. 2007;50(2):156-60. doi: 10.1159/000098242. IF 1.8, citations 15
141. Riva E, Serraino D, Pierangeli A, Bambacioni F, Zaniratti S, Minosse C, Selleri M, Bucci M, Scagnolari C, Degener AM, Capobianchi MR, Antonelli G, Dianzani F; Roman Papillomavirus Study Group*. Markers of human papillomavirus infection and their correlation with cervical dysplasia in human immunodeficiency virus-positive women. Clin Microbiol Infect. 2007;13(1):94-7. doi: 10.1111/j.1469-0691.2006.01568.x. IF 2.9, citations 13
142. Santantonio T, Milella M, Antonelli G, Scagnolari C. Neutralizing antibodies to interferon alpha in a chronic hepatitis C patient non-responder to pegylated interferon. J Hepatol. 2006;45(5):759-61. doi: 10.1016/j.jhep.2006.08.007. IF 6.0, citations 13
143. Di Marco P, Pagnotti P, Bellomi F, De Vito G, Sessa E, Bagnato F, Scagnolari C, Bramanti P, Antonelli G. A novel assay to detect low-titred antibodies to interferon beta in multiple sclerosis patients. New Microbiol. 2006;29(1):11-8. IF NA, citations 1
144. Scagnolari C, Vicenzi E, Bellomi F, Stillitano MG, Pinna D, Poli G, Clementi M, Dianzani F, Antonelli G. Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons. Antivir Ther. 2004;9(6):1003-11. IF 6.0, citations 75
145. Maffeo A, Bellomi F, Solimeo I, Bambacioni F, Scagnolari C, De Pisa F, Dupuis ML, Cianfriglia M, Antonelli G, Turriziani O. P-glycoprotein expression affects the intracellular concentration and antiviral activity of the protease inhibitor saquinavir in a T cell line. New Microbiol. 2004;27(2 Suppl 1):119-26. IF NA, citations 13
146. Bagnato F, Clemenzi A, Scagnolari C, Strizzi L, Di Pasquale A, Bellomi F, Di Marco P, Antonelli G, Antonini G. Neutralizing antibodies against endogenous interferon in myasthenia gravis patients. Eur Cytokine Netw. 2004;15(1):24-9. IF 1.7, citations 10
147. Turriziani O, Scagnolari C, Bellomi F, Solimeo I, Focher F, Antonelli G. Cellular issues relating to the resistance of HIV to antiretroviral agents. Scand J Infect Dis Suppl. 2003;106:45-8. doi: 10.1080/03008870310009669. IF 1.1, citations 6
148. Casato M, Lilli D, Donato G, Granata M, Conti V, Del Giudice G, Rivanera D, Scagnolari C, Antonelli G, Fiorilli M. Occult hepatitis C virus infection in type II mixed cryoglobulinaemia. J Viral Hepat. 2003;10(6):455-9. doi: 10.1046/j.1365-2893.2003.00462.x. IF 3.2, citations 34
149. Bellomi F, Scagnolari C, Tomassini V, Gasperini C, Paolillo A, Pozzilli C, Antonelli G. Fate of neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 years. J Neurol Sci. 2003;215(1-2):3-8. doi: 10.1016/s0022-510x(03)00173-4. IF 2.1, citations 57
150. Antonelli G, Scagnolari C, Vicenzi E, Clementi M. Treatment of SARS with human interferons. Lancet. 2003;362(9390):1158; author reply 1158-9. doi: 10.1016/S0140-6736(03)14482-0. IF 18, citations 7
151. Riva E, Antonelli G, Scagnolari C, Pistello M, Capobianchi MR, Monforte Ad, Pezzotti P, Dianzani F; I.CO.N.A. Study Group. Human immunodeficiency virus (HIV) DNA load and level of immunosuppression in treatment-naive HIV-1-infected patients. J Infect Dis. 2003;187(11):1826-8. doi: 10.1086/375251. IF 4.4, citations 15
152. Scagnolari C, Casato M, Bellomi F, De Pisa F, Turriziani O, Coviello R, Pirro MR, Dianzani F, Antonelli G. Serum interferon (IFN)-neutralizing antibodies and bioactivities of IFNs in patients with severe type II essential mixed cryoglobulinemia. Clin Diagn Lab Immunol. 2003;10(1):70-7. doi: 10.1128/cdli.10.1.70-77.2003. IF 1.8, citations
153. Turriziani O, Scagnolari C, Bambacioni F, Bellomi F, Focher F, Gentile M, Antonelli G. Selection of a T-cell line resistant to stavudine and zidovudine by prolonged treatment with stavudine. Antivir Ther. 2002;7(2):105-11. IF 6.5, citations 4
154. Monzani F, Meucci G, Caraccio N, Saviozzi M, Casolaro A, Moscato G, Lombardo F, Mosti S, Scagnolari C, Bruschi F, Antonelli G, Ferrannini E, Murri L. Discordant effect of IFN-beta1a therapy on anti-IFN antibodies and thyroid disease development in patients with multiple sclerosis. J Interferon Cytokine Res. 2002;22(7):773-81. doi: 10.1089/107999002320271369. IF 1.8, citations 19
155. Giannelli G, De Marzo A, Scagnolari C, Bergamini C, Fransvea E, Bagnato F, Bellomi F, Millefiorini E, Gasperini C, Antonaci S, Antonelli G. Proteolytic balance in patients with multiple sclerosis during interferon treatment. J Interferon Cytokine Res. 2002; 22(6):689-92. doi: 10.1089/10799900260100187. IF 1.8, citations 6
156. Turriziani O, Schuetz JD, Focher F, Scagnolari C, Sampath J, Adachi M, Bambacioni F, Riva E, Antonelli G. Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11. Biochem J. 2002;368(Pt 1):325-32. doi: 10.1042/BJ20020494. IF 4.5, citations 30
157. Bagnato F, Pozzilli C, Scagnolari C, Bellomi F, Pasqualetti P, Gasperini C, Millefiorini E, Galgani S, Spadaro M, Antonelli G. A one-year study on the pharmacodynamic profile of interferon-beta1a in MS. Neurology. 2002;58(9):1409-11. doi: 10.1212/wnl.58.9.1409. IF 5.3, citations 18
158. Scagnolari C, Bellomi F, Turriziani O, Bagnato F, Tomassini V, Lavolpe V, Ruggieri M, Bruschi F, Meucci G, Dicuonzo G, Antonelli G. Neutralizing and binding antibodies to IFN-beta: relative frequency in relapsing-remitting multiple sclerosis patients treated with different IFN-beta preparations. J Interferon Cytokine Res. 2002;22(2):207-13. doi: 10.1089/107999002753536176. IF 1.8, citations 56
*press/media releases related to the selected publications
Fracella M, Mancino E, Nenna R, Virgillito C, Frasca F, D'Auria A, Sorrentino L, Petrarca L, La Regina D, Matera L, Di Mattia G, Caputo B, Antonelli G, Pierangeli A, Viscidi RP, Midulla F, Scagnolari C. Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID. Eur J Immunol. 2024 :e2350682. doi: 10.1002/eji.202350682. IF 4.5, citations 0, press/media release (if any)*
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Pierangeli A, Nenna R, Fracella M, Scagnolari C, Oliveto G, Sorrentino L, Frasca F, Conti MG, Petrarca L, Papoff P, Turriziani O, Antonelli G, Stefanelli P, Palamara AT, Midulla F. Genetic diversity and its impact on disease severity in respiratory syncytial virus subtype-A and -B bronchiolitis before and after pandemic restrictions in Rome. J Infect. 2023;87(4):305-314. doi: 10.1016/j.jinf.2023.07.008. IF 14.3, citations 18, press/media release (if any)* see selected publications.
Frasca F, Scordio M, Santinelli L, Gabriele L, Gandini O, Criniti A, Pierangeli A, Angeloni A, Mastroianni CM, d'Ettorre G, Viscidi RP, Antonelli G, Scagnolari C. Anti-IFN-α/-ω neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity. Eur J Immunol. 2022;52(7):1120-1128. doi: 10.1002/eji.202249824. IF 5.4, citations 28, press/media release (if any)* see selected publications
Book Chapter
1. MicroRNAs and the immune system Frasca F, Scordio M, Scagnolari C. MicroRNA: From Bench to Bedside, 2022, pp. 279–305 Book https://doi.org/10.1016/B978-0-323-89774-7.00007-8 (Book Chapter scientific)
2. Principi di Microbiologia. Scagnolari C Chapter: Sistema Interferon. Casa editrice Ambrosiana (Book Chapter teaching)