Notizie
La didattica per Farmacologia e Tossicologia, IV Anno, II Semestre, viene erogata mediante lezioni in presenza.
Orari di ricevimento
Lunedì: 12.00-14.00
Curriculum
CURRICULUM VITAE
Nome: Giuseppe
Cognome: Battaglia
Luogo e data di nascita: Caltagirone, 13 Febbraio 1964
Cittadinanza: Italiana
Stato Civile Celibe
Indirizzo: Via Campania, 37
Venafro 86079 (IS)
Istituto di appartenenza: Istituto Neurologico Mediterraneo
NEUROMED
Località Camerelle,
86077, Pozzilli (IS)
Tel.: 0865-915201
Fax: 0865-927575
E-mail: giuseppe.battaglia@neuromed.it
Titoli conseguiti:
1983 - Maturità Scientifica (50/60)
1990 - Laurea in Medicina e Chirurgia (110/110 e Lode), Università di Catania
2001 - Dottorato di Ricerca in Neurobiologia
Training:
1986-87 Internato presso l’Istituto di Biochimica, Facoltà di Medicina, Università di Catania
1988-92 Ricercatore presso i Laboratori di Ricerca della Fidia Research Sud, Siracusa
1992-94 Medico interno tirocinante presso l’Istituto di Farmacologia, Facoltà di Medicina,
Università di Catania
1995-97 Postdoctoral Fellow presso Eli Lilly Research Laboratories, Dipartimento di
Ricerca in Malattie del Sistema Nervoso Centrale, Indianapolis (USA)
1997-97 Postdoctoral Fellow presso Maryland Psychiatric Research Center,
Università del Maryland, Facoltà di Medicina, Baltimore (USA)
1997-99 Medico interno presso l’Istituto Neurologico Mediterraneo - NEUROMED, Pozzilli (IS)
2000-02 Assistente Medico presso l’Istituto Neurologico Mediterraneo - NEUROMED, Pozzilli (IS)
2002 - Aiuto Medico presso l’Istituto Neurologico Mediterraneo - NEUROMED, Pozzilli (IS)
Posizione Attuale:
- Aiuto Medico presso l’Istituto Neurologico Mediterraneo - NEUROMED, Pozzilli (IS)
- Responsabile del Laboratorio Radioisotopi dell’Istituto Neurologico Mediterraneo - NEUROMED, Pozzilli (IS)
Premi:
1998 - Vincitore del Premio di Studio “PROFESSOR MOSE’ DA PRADA”, bandito dalla Lega Italiana per la Lotta contro il Morbo di Parkinson, le Malattie Extrapiramidali e le Demenze (LIMPE), e sponsorizzato dalla Roche Pharmaceuticals S.P.A.
2003 - Vincitore del Premio Farmindustria - Società Italiana di Farmacologia (SIF) per Ricerche Farmacologiche riservato a Soci SIF di età inferiore ai 40 anni.
2003 - Vincitore della sessione poster “Controllo farmacologico della morte cellulare e dei processi degenerativi” al 31° Congresso Nazionale della Società Italiana di Farmacologia, Trieste 26-29 giugno 2003.
Corsi di Insegnamento:
1997-2012 Fisiologia Umana per il Corso di Diploma Universitario in Tecnico Sanitario di Laboratorio Biomedico, Università degli Studi “Sapienza”, Roma.
2000-2001 Biofisica per i Corsi di Diploma Universitario in Tecnico Sanitario di Laboratorio Biomedico ed in Fisioterapista, Università degli Studi “Sapienza”, Roma.
2003-2012 Fisiologia Umana per il Corso di Diploma Universitario in Fisioterapista, Università degli Studi “Sapienza”, Roma.
Società d’appartenenza:
- American Society for Neuroscience
- Società Italiana di Farmacologia (SIF)
Membro dell’Editorial Bord di Molecular Pharmacology
Membro del Review Committee in Medicina all’European Synchrotron Radiation Facility, Grenoble, Francia
Referee di riviste internazionali:
Molecular Pharmacology
Neuropsycopharmacology
Neuropharmacology
British Journal of Pharmacology
Current Neuropharmacology
Behavioural Pharmacology
Journal of Neurochemistry
Neuroscience Letters
European Journal of Neuroscience
Neurodegenerative Diseases
Neuroscience
Parkinson’s Disease
Molecular and Cellular Neuroscience
Scientific Reports
International Journal of Developmental Neuroscience
PUBBLICAZIONI IN LINGUA INGLESE SU RIVISTE A COMITATO DI REFEREE
Impact Factor totale: 613,9 (131 pubblicazioni)
Impact Factor medio: 4,68 (131 pubblicazioni)
Gli Impact Factors sono stati calcolati dai "Journal Citation Reports" secondo l'anno di pubblicazione del lavoro.
1. Bruno V., Copani A., Battaglia G., Raffaele R., Shinozaki H., Nicoletti F. Protective effect of metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death. Eur. J. Pharmacol., 1994, 256: 109-112. (I.F. 2.677)
2. Bruno V., Battaglia G., Copani A., Sortino M. A., Canonico P.L., Nicoletti F. Protective actions of idebenone against excitoxic degeneration in cultured cortical neurons. Neurosci. Lett., 1994, 178: 193-196. (I.F. 2.703)
3. Copani A., Bruno V.M.G., Barresi V., Battaglia G., Condorelli D.F., Nicoletti F. Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture. J. Neurochem., 1995, 64: 101-108. (I.F. 4.852)
4. Bruno V., Battaglia G., Copani A., Giffard R.G., Dell’Albani P., Raciti G., Condorelli D.F., Nicoletti F. Activation of metabotropic glutamate receptor subtypes negatively linked to adenylyl cyclase protects cultured cortical neurons against excitotoxic degeneration. Eur. J. Neurosci., 1995, 7: 1906-1913. (I.F. 4.921)
5. Copani A., Bruno V., Dell'Albani P., Battaglia G., Barresi V., Caruso A., Nicoletti F., Condorelli D.F. Growth conditions differentialy affect the constitutive expression of primary response genes in cultured cerebellar granule cells. Neurochemical Res., 1995, 20: 611-616 (I.F. 1.577)
6. Copani A., Bruno V., Battaglia G., Leanza G., Pellitteri A., Russo S., Stanzani S., Nicoletti F. Activation of metabotropic glutamate receptors protect cultured neurons against apoptosis induced by -amiloyd peptide. Mol. Pharmacol., 1995, 47: 890:897. (I.F. 6.580)
7. Di Iorio P., Battaglia G., Ciccarelli R., Ballerini P., Giuliani P., Poli A., Nicoletti F., Caciagli F. Interaction between A1 Adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices. J. Neurochem., 1996, 67: 302-309. (I.F. 4.852)
8. Bruno V., Copani A., Battaglia G., Dell'Albani P., Condorelli D.F., Nicoletti F. Metabotropic glutamate receptors and neuronal degeneration in culture. Adv. Neurol., 1996, 71: 47-51. (I.F. 0.968)
9. Battaglia G., Monn J.A., Schoepp D.D. In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats. Neurosci Lett., 1997, 229: 161-164. (I.F. 1.394)
10. Battaglia G., Bruno V., Ngomba T.R., Di Grezia R., Copani A., Nicoletti F. Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death. E. J. Pharmacol., 1998, 356: 271-274. (I.F. 1.992)
11. Bruno V., Battaglia G., Casabona G., Copani A., Caciagli F., Nicoletti F. Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-β. J. Neurosci., 1998, 18: 9594-9600. (I.F. 8.403)
12. Bruno V., Battaglia G., Copani A., Casabona G., Storto M., Di Giorgi Gerevini V., Ngomba R.T., Nicoletti F. Metabotropic glutamate receptors and neurodegeneration. Prog. Brain Res., 1998, 116: 209-221. (I.F. 2.520)
13. Bruno V., Battaglia G., Kingston A., O’Neill J.M., Catania M.V., Di Grezia R., Nicoletti F. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4-carboxyphenilglycine (LY367385): comparison with LY367366, an antagonist of mGlu1a and mGlu5 receptors. Neuropharmacology, 1999, 38: 199-207. (I.F. 3.240)
14. Gasparini F., Bruno V., Battaglia G., Lukic S., Leonhardt T., Inderbitzin W., Laurie D., Sommer B., Varney M.A., Hess S.D., Johnson C.E., Kuhn R., Urwyler S., Sauer D., Portet C., Schmutz M., Nicoletti F., Flor J. P. (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J. Pharmacol. Exp. Ther., 1999, 289: 1678-1687. (I.F. 3.051)
15. Ciccarelli R., Di Iorio P., Bruno V., Battaglia G., D’Alimonte I., D’Onofrio M., Nicoletti F., Caciagli F. Activation of A1 adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100β protein from cultured astrocytes. Glia, 1999, 27: 275-281. (I.F. 3.670)
16. Nicoletti F., Bruno V., Catania M.V., Battaglia G., Copani A., Barbagallo G., Ceña V., Sanchez-Prieto J., Spano P.F., Pizzi M. Group-I metabotropic glutamate receptors: hypoteses to explain their dual role in neurotoxicity and neuroprotection. Neuropharmacology, 1999, 38: 1477-1484. (I.F. 3.240)
17. Kingston A.E., O'Neill M.J., Bond A., Bruno V., Battaglia G., Nicoletti F., Harris J.R., Clark B.P., Monn J.A., Lodge D., Schoepp D.D. Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors. Ann. N. Y. Acad. Sci., 1999, 890: 438-849. (I.F. 0.959)
18. Battaglia G., La Russa M., Bruno V., Arenare L., Ippolito R., Copani A., Bonina F., Nicoletti F. Systemically administered D-glucose conjugates of 7-chlorokynurenic acid protect against N-methyl-D-aspartate-induced seizure in mice. Brain Res., 2000, 860: 149-156. (I.F. 2.150)
19. Bonina F.P., Arenare L., Ippolito R., Boatto G.P., Battaglia G., Bruno V., De Capraris P. Sinthesys, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs. Int. J. Pharm., 2000, 202: 79-88. (I.F. 0.978).
20. Bruno V., Battaglia G., Ksiazek I., v.d. Putten H., Lukic S., Leonhardt T., Inderbitzin W., Gasparini F., Kuhn R., Hampson D., Nicoletti F., Flor P.J. Neuroprotective activity of group-III metabotropic glutamate receptor agonists in cultured cortical neurons is mediated by the mGluR4 subtype. J. Neurosci., 2000, 20: 6413-6420. (I.F. 8.403)
21. Storto M., De Grazia U., Battaglia G., Felli M.P., Maroder M., Gulino A., Ragona G., Nicoletti F., Screpanti I., Calogero A. Expression of metabotropic glutamate receptors in mouse thymic cells. J. Neuroimmunol., 2000, 109: 112-120. (I.F. 3.285)
22. Bruno V., Ksiazek I., Battaglia G., Lukic S., Leonhardt T., Sauer D., Gasparini F., Kuhn R., Nicoletti F., Flor P.J. Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective. Neuropharmacology, 2000, 39: 2223-2230. (I.F. 3.240)
23. Battaglia G.*, Rassoulpour A.*, Wu Q. H., Hodgkins P.S., Kiss C., Nicoletti F., Schwarcz R. Metabotropic glutamate receptor ligands reduce kynurenate synthesis by intracellular inhibition of kynurenine amino transferase II. J. Neurochem., 2000, 75: 2051-2060. (I.F. 4.651) *co-first authors
24. Fornai F., Battaglia G., Di Grezia R., Orzi F., Nicoletti F., Ruggieri S. Time-course and dose-response study on the effects of chronic L-DOPA administration on striatal dopamine levels and dopamine transporter following MPTP toxicity. Brain Res., 2000, 887: 110-117. (I.F. 2.150)
25. Fornai F., Battaglia G., Gesi M., Orzi F., Nicoletti F., Ruggieri S. Dose-dependent protective effects of apomorphine against methamphetamine-induced nigrostriatal damage. Brain Res., 2001, 898: 27-35. (I.F. 2.150)
26. Bruno V., Battaglia G., Copani A., Cespédes M.V, Galindo M. F., Ceña V, Sánchez-Prieto J., Gasparini F., Kuhn R., Flor P.J., Nicoletti F. An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group-I metabotropic glutamate receptors. Eur. J. Neurosci., 2001, 13: 1469-1478. (I.F. 4.921)
27. Battaglia G., Bruno V., Pisani A., Centonze D., Catania M.V., Calabresi P., Nicoletti F. Selective blockade of type-I metabotropic glutamate receptors induces neuroprotection by enhancing GABAergic transmission. Mol. Cell. Neurosci., 2001, 17: 1071-1083. (I.F. 5.654)
28. D’Onofrio M., Cuomo L., Battaglia G., Ngomba T.R., Storto M., Kingston A.E., Orzi F., De Blasi A., Di Iorio P., Nicoletti F., Bruno V. Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. J. Neurochem., 2001, 78: 435-445. (I.F. 4.651)
29. Bruno V., Battaglia G., Copani A., D’Onofrio M., Di Iorio P., De Blasi A., Melchiorri D., Flor J.P., Nicoletti F. Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J. Cereb. Blood Flow Metab., 2001, 21: 1013-1033. (I.F. 5.714)
30. Flor P.J., Battaglia G., Nicoletti F., Gasparini F., Bruno V. Neuroprotective activity of metabotropic glutamate receptor ligands. Adv. Exp. Med. Biol., 2002, 513: 197-223. (I.F. 0.513)
31. Battaglia G., Fornai F., Busceti L.C., Aloisi G., Cerrito F., De Blasi A., Melchiorri D., Nicoletti F. Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity. J. Neurosci., 2002, 22: 2135-2141. (I.F. 8.502)
32. Battaglia G., Busceti L.C., Cuomo L., Giorgi S. F., Orzi F., De Blasi A., Nicoletti F., Ruggieri S., Fornai F. Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice. Neuropharmacology, 2002, 42: 367-373. (I.F. 4.125)
33. Besong G.*, Battaglia G.*, D’Onofrio M.*, Di Marco R., Ngomba T.R., Storto M., Castiglione M., Mangano K., Busceti L.C., Nicoletti R.F., Bacon K., Tusche M., Valenti O., Conn J.P., Bruno V., Nicoletti F. Activation of group-III metabotropic glutamate receptors inhibits the production of rantes in glial cell cultures. J. Neurosci., 2002, 22: 5403-5411. (I.F. 8.502) *co-first authors
34. Battaglia G., Gesi M., Lenzi P., Busceti L.C., Soldani P., Orzi F., Rampello L., Nicoletti F., Ruggieri S., Fornai F. Morphological and biochemical evidence that apomorphine rescues striatal DA terminals and prevents methamphetamine toxicity. Ann. N. Y. Acad. Sci., 2002, 965: 254-266. (I.F. 1.381)
35. Picconi B., Pisani A., Centonze D., Battaglia G., Storto M., Nicoletti F., Bernardi G., Calabresi P. Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment. Brain, 2002, 125: 2635-2645. (I.F. 7.303)
36. Copani A., Sortino M.A., Caricasole A., Chiechio S., Chisari M., Battaglia G., Giuffrida-Stella A.M., Vancheri C., Nicoletti F. Erratic expression of DNA polymerases by -amyloid causes neuronal death. FASEB J. 2002, 16:2006-2008. (I.F. 9.249)
37. Storto M., Ngomba T.R., Battaglia G., Freitas I., Griffino P., Richelmi P., Nicoletti F., Vairetti M. Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. J. Hepatol., 2003, 38: 179-187. (I.F. 3.761)
38. D’Onofrio M., Arcella A., Bruno V., Battaglia G., Ngomba T.R., Lombari V., Ragona G., Calogero A., Nicoletti F. Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells. J. Neurochem., 2003, 84: 1288-1295. (I.F. 4.651)
39. Scaccianoce S., Matrisciano F., Del Bianco P., Caricasole A., Di Giorgi Gerevini V., Cappuccio I., Melchiorri D., Battaglia G., Nicoletti F. Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis. Neuropharmacology, 2003, 44: 555-561. (I.F. 4.125)
40. Battaglia G., Busceti L.C., Pontarelli F., Fornai F., Paparelli A., Bruno V., Ruggieri S., Nicoletti F. Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Neuropharmacology, 2003, 45: 155-166. (I.F. 4.125)
41. Poli A., Beraudi A., Villani L., Storto M., Battaglia G., Di Giorgi Gerevini V., Cappuccio I., Caricasole A., D’Onofrio M., Nicoletti F. Group-II metabotropic glutamate receptors regulate the vulnerability to hypoxic brain damage. J. Neurosci., 2003, 23: 6023-6029. (I.F. 8.502)
42. Battaglia G., Fornai F., Busceti L.C., Lembo G., Nicoletti F., De Blasi A. Alpha-1b adrenergic receptor knockout mice are protected against methamphetamine toxicity. J. Neurochem., 2003, 86: 413-421. (I.F. 4.651)
43. Maj M., Bruno V., Dragic Z., Battaglia G., Inderbitzin W., Stein T., Gasparini F., Kuhn R., van der Putten H., Nicoletti F., Flor J.P. (-)-PHCCC, a positive allosteric modulator selective for metabotropic glutamate receptor subtype 4: pharmacological and molecular characterization. Neuropharmacology 2003, 45: 895-906. (I.F. 4.125)
44. Stocchi F., Vacca L., Grassini P., Battaglia G., Onofrj M., Valente M., Ruggieri S. Optimizing levodopa pharmacokinetics in Parkinson’s disease: the role of COMT inhibitor. Neurol. Sci., 2003, 24: 217-218. (I.F. 0.38 )
45. Fornai F., Lenzi P., Gesi M., Soldani P, Ferrucci M, Lazzeri G., Capobianco L., Battaglia G., De Blasi A., Nicoletti F., Paparelli A. Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells. J. Neurochem., 2004, 88: 114-123. (I.F. 4.651)
46. Battaglia G., Busceti L.C., Molinaro G., Biagioni F., Storto M., Fornai F., Nicoletti F., Bruno V. Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. J. Neurosci., 2004, 24: 828-835. (I.F. 8.502)
47. Storto M., Battaglia G., Gradini R., Bruno V., Nicoletti F., Vairetti M.P. Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage. Eur. J. Pharmacol., 2004, 497: 25-27. (I.F. 2.164)
48. Chandra S., Fornai F., Kwon H.B., Yazdani U., Atasoy D., Liu X., Hammer E.R., Battaglia G., German C.D., Castello E.P., Südhof C.T. Double knockout mice for α- and β-synucleins: effect on synaptic functions. P. Natl. Acad. Sci. USA., 2004, 101: 14966-14971. (I.F. 10.272)
49. Fornai F., Lenzi P., Gesi M., Ferrucci M., Lazzeri G., Capobianco L., De Blasi A., Battaglia G., Nicoletti F., Ruggieri S., Paparelli A. Similarities between methamphetamine toxicity and proteasome inhibition. Ann. N. Y. Acad. Sci., 2004, 1025: 162-170. (I.F. 1.892)
50. Fornai F., Gesi M., Lenzi P., Ferrucci M., Lazzeri G., Pizzanelli C., Pellegrini A., Battaglia G., Ruggieri S., Paparelli A. Effects of repeated low doses of MDMA on EEG activity and fluoro-jade B histochemistry. Ann. N. Y. Acad. Sci., 2004, 1025: 181-188. (I.F. 1.892)
51. Canudas A.M., DiGiorgi Gerevini V., Iacovelli L., D’Onofrio M., Arcella A., Giangaspero F., Busceti C.L., RicciVitiani L., Battaglia G., Melchiorri D., Nicoletti F. PHCCC, a specific enhancer of mGlu4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. J. Neurosci., 2004, 24: 10343-10352. (I.F. 8.306)
52. Fornai F., Schlüter O.M., Lenzi P., Gesi M., Ruffoli R., Ferrucci M., Lazzeri G., Busceti C.L., Pontarelli F., Battaglia G., Pellegrini A., Nicoletti F., Ruggieri S., Paparelli A., Südhof C.T. Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and α-synuclein. P. Natl. Acad. Sci. USA., 2005, 102: 3413-3418. (I.F. 10.272)
53. Cappuccio I., Calderone A., Busceti C.L., Biagioni F., Pontarelli F., Bruno V., Storto M., Calderone A., Terstappen G.T., Gaviraghi G., Fornai F., Battaglia G., Melchiorri D., Zukin S., Nicoletti F., Caricasole A. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death. J. Neurosci., 2005, 25: 2647-2657. (I.F. 8.306)
54. Rampello L., Alvano A., Battaglia G., Raffaele R., Vecchio I., Malaguarnera M. Different clinical and evolutional patterns in late idiopathic and vascular parkinsonism. J. Neurol., 2005, 252: 1045-1049. (I.F. 2.778)
55. Matrisciano F., Scaccianoce S., Del Bianco P., Panaccione I., Canudas A.M., Battaglia G., Riozzi B., Ngomba R.T., Molinaro G., Tatarelli R., Melchiorri D., Nicoletti F. Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with mGlu2/3 receptor ligands. J. Neurochem., 2005, 93: 1345-1352. (I.F. 4.651)
56. Arcella A., Carpinelli G., Battaglia G., D’Onofrio M., Santoro F., Ngomba T.R., Bruno V., Casolini P., Giangaspero F., Nicoletti F. Pharmacological blockade of group-II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 2005, 7: 236-245. (I.F. 3.365)
57. Di Giorgi-Gerevini V., Melchiorri D., Battaglia G., Busceti L.C., Biagioni F., Ricci-Vitiani L., Iacovelli L., Canudas A.M., Bez A., Parati E., De Maria R., Nicoletti F. Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural stem cells. Cell Death Diff., 2005, 12: 1124-1133. (I.F. 7.008)
58. Caraci F., Chisari M., Frasca G., Canonico P.L., Battaglia A., Calafiore M., Battaglia G., Bosco P., Nicoletti F., Copani A., Sortino M.A. Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity. Brain Res. 2005, 1047: 30-37. (I.F. 2.474)
59. Ngomba R.T., Biagioni F., Casciato S., Willems-van Bree E., Battaglia G., Bruno V., Nicoletti F., van Luijtelaar E.L.J.M. The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 2005, 49: 89-103. (I.F. 3.801)
60. Conn J.P., Battaglia G., Marino M.J., Nicoletti F. Metabotropic glutamate receptors in the basal ganglia motor circuit. Nat. Rev. Neurosci., 2005, 6: 787-798 (I.F. 27.007)
61. Cappuccio I., Spinsanti P., Porcellini A., Desiderati F., De Vita T., Storto M., Capobianco L., Battaglia G., Nicoletti F., Melchiorri D. Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells. Neuropharmacology, 2005, 49: 196-205. (I.F. 3.801)
62. Rampello L., Battaglia G., Raffaele R., Vecchio I., Alvano A. Is it safe to use antidepressants after a stroke? Expert Opin. Drug Saf., 2005, 4: 885-897.
63. Rampello L., Butta V., Raffaele R., Vecchio I., Battaglia G., Cormaci G., Alvano A. Progressive supranuclear palsy: a systematic review. Neurobiol. Dis., 2005, 20: 179-186 (I.F. 4.389)
64. Calafiore M., Battaglia G., Zappalà A., Trovato-Salinaro E., Caraci F., Caruso M., Vancheri C., Sortino M.A., Nicoletti F., Copani A. Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to -amyloid. Neurobiol. Aging, 2006, 27: 606-613. (I.F. 5.552)
65. Rampello L., Alvano A., Battaglia G., Bruno V., Raffaele R., Nicoletti F. Tic disorders: from pathophysiology to treatment. J. Neurol., 2006, 253: 1-15. (I.F. 2.778)
66. Storto M., Capobianco L., Battaglia G., Molinaro G., Gradini R., Riozzi B., Mitchel J.K., Bruno V., Vairetti M.P., Rutter G.Y., Nicoletti F. Insulin secretion is under the control of type-5 metabotropic glutamate receptors. Mol. Pharmacol., 2006, 69:1234-1241. (I.F. 5.08)
67. Calò L., Cinque C., Patanè M., Schillaci D., Battaglia G., Melchiorri D., Nicoletti F., Bruno V. Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration. J. Neurochem., 2006, 98:1-10. (I.F. 4.651)
68. Battaglia G., Busceti C.L., Molinaro G., Biagioni F., Traficante F., Nicoletti F., Bruno V. Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigro-striatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Neurosci., 2006, 26: 7222-7229. (I.F. 8.306)
69. Castri P., Busceti C., Battaglia G., Girardi F., Cavallari M., Orzi F., Fornai F. Protection by apomorphine in two independent models of acute inhibition of oxidative metabolism in rodents. Clin. Exp. Hypertens., 2006, 28: 387-94. (I.F. 0.99)
70. Iacovelli L., Arcella A., Battaglia G., Pazzaglia S., Aronica E., Spinsanti P., Caruso A., De Smaele E., Saran A., Gulino A., D’Onofrio M., Giangaspero F., Nicoletti F. Inhibition of medulloblastoma growth by type-4 metabotropic glutamate receptors. J. Neurosci., 2006, 26: 8388-8397. (I.F. 8.306).
71. Stocchi F., Vacca L., Grassini P., De Pandis M.F., Battaglia G., Cattaneo C., Fariello R.G. Symptom relief in Parkinson disease by safinamide: Biochemical and clinical evidence of efficacy beyond MAO-B inhibition. Neurology, 67(7 Suppl 2): S24-29, 2006. (I.F. 5.678)
72. Biagioni F., Busceti C.L., Molinaro G., Battaglia G., Giorgi F.S., Ruggieri S., Fornai F. Dopamine stimulation via infusion in the lateral ventricle. Ann. N.Y. Acad. Sci., 2006, 1074: 337-343. (I.F. 1.892)
73. Giorgi F.S., di Poggio A.B., Battaglia G., Pellegrini A., Murri L., Ruggieri S., Paparelli A., Fornai F. A short overview on the role of alpha-synuclein and proteasome in experimental models of Parkinson's disease. J. Neural Transm. Suppl., 2006, 70: 105-109. (I.F. 2.512)
74. Battaglia G.*, Farrace M.G.*, Mastroberardino P.G., Viti I., Fimia G.M., Van Beeumen J., Devreese B., Molinaro G., Busceti C.L., Biagioni F., Nicoletti F., Piacentini M. Transglutaminase 2 ablation leads to defective function of mitochondrial respiratory complex I affecting neuronal vulnerability in experimental models of extrapyramidal disorders. J. Neurochem., 2007, 100: 36-49. (I.F. 4.651). *co-first authors
75. Beraudi A., Bruno V., Battaglia G., Rampello L., Nicoletti F., Poli A. Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish carassius auratus. Exp. Eye Res., 2007, 84: 544-552. (I.F. 2.611)
76. Busceti C.L., Biagioni F., Aronica E., Riozzi B., Storto M., Battaglia G., Giorgi F.S., Gradini R., Fornai F., Caricasole A., Nicoletti F., Bruno V. Induction of the Wnt inhibitor, dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy. Epilepsia, 2007, 48: 694-705. (I.F. 3.227).
77. Nicoletti F., Arcella A., Iacovelli L., Battaglia G., Gìangaspero F., Melchiorri D. Metabotropic glutamate receptors: new targets for the control of tumor growth? Trends Pharmacol, 2007, 28: 206-213. (I.F. 10.372).
78. Corti C*., Battaglia G.*, Molinaro G., Riozzi B., Pittaluga A., Corsi M., Nicoletti F., Bruno V. The use of knockout mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J. Neurosci., 2007, 27: 8297-8308. (I.F. 7,506) *co-first authors
79. Nicoletti F., Battaglia G., Storto M., Ngomba R., Iacovelli L., Arcella A., Gradini R., Sale P., Rampello L., De Vita T., Di Marco R., Melchiorri D., Bruno V. Metabotropic glutamate receptors: beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 2007, 32:S40-S45 (I.F. 4.381).
80. Traficante A., Riozzi B., Cannella M., Rampello L., Squitieri F., Battaglia G. Reduced activity of striatal glutamatergic fibres in the R6/2 mouse model of Huntington’s disease. NeuroReport, 2007, 18: 1997-2000. (I.F. 1.995).
81. Ngomba R.T., Ferraguti F., Badura A., Citraro R., Santolini I., Battaglia G., Bruno V., De Sarro G., Simonyi A., van Luijtelaar G., Nicoletti F. Selective activation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 2008, 54:344-354. (I.F. 3.801)
82. Matrisciano F., Zusso M., Panaccione I., Turriziani B., Caruso A., Iacovelli L., Noviello L., Togna G., Melchiorri D., Debetto P., Tatarelli R., Battaglia G., Nicoletti F., Giusti P., Girardi P. Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis. Neuropharmacology, 2008, 54:428-437. (I.F. 3.801)
83. Molinaro G., Battaglia G., Riozzi B., Storto M., Fucile S., Eusebi F., Nicoletti F., Bruno V. GABAergic drugs become neurotoxic in cortical neurons pre-exposed to brain-derived neurotrophic factor. Mol. Cell. Neurosci., 2008, 37:312-322. (I.F. 4.607)
84. Busceti C.L., Biagioni F., Riozzi B., Battaglia G., Storto M., Cinque C., Molinaro G., Gradini R., Caricasole A., Canudas A.M., Bruno V., Nicoletti F., Fornai F. Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylendioxymethamphetamine (“ecstasy”). J. Neurosci., 2008, 28:3234-3245. (I.F. 7.506). Recensito in Nature Medicine, 2008, 14(5):492.
85. Sarichelou I., Cappuccio I., Ferranti F., Mosillo P., Ciceroni C., Sale P., Stocchi F., Battaglia G., Nicoletti F., Melchiorri D. Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons. Cell Death Differ., 2008, 15:700-707. (I.F. 7.463)
86. Caraci F., Battaglia G., Busceti C., Biagioni F., Mastroiacovo F., Bosco P., Drago F., Nicoletti F., Sortino M.A., Copani A. TGF-β 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway. Neurobiol Dis., 2008, 30:234-342. (I.F. 4.128).
87. Caraci F., Busceti C., Biagioni F., Aronica E., Mastroiacovo F., Cappuccio I., Battaglia G., Bruno V., Caricasole A., Nicoletti F., Copani A. The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders. Neurochem. Res., 2008, 33:2401-2406. (I.F. 2.139).
88. Messina S., Molinaro G., Bruno V., Battaglia G., Spinsanti P., Di Pardo A., Nicoletti F., Frati L., Porcellini A. Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes. J. Neurochem., 2008, 106:551-559. (I.F. 4.651).
89. Matrisciano F., Caruso A., Orlando R., Marchiafava M., Bruno V., Battaglia G., Gruber S.H.M., Melchiorri D., Tatarelli R., Girardi P., Mathè A.A., Nicoletti F. Defective group-II metabotropic glutamate receptors in the hippocampus of spontaneously depressed rats. Neuropharmacology, 2008, 55:525-531. (I.F. 3.801)
90. Fazio F., Notartomaso S., Aronica E., Storto M., Battaglia G., Gatti S., Bruno V., Biagioni F., Gradini R., Nicoletti F., Di Marco R. Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis. Neuropharmacology, 2008, 55(4):491-499. (I.F. 3.801)
91. Ciceroni C., Arcella A., Mosillo P., Battaglia G., Mastrantoni E., Oliva M.A., Carpinelli G., Santoro F., Sale P., Ricci-Vitiani L., De Maria R., Pallini R., Giangaspero F., Nicoletti F., Melchiorri D. Pharmacological blockade of mGlu3 metabotropic glutamate receptors enhances differentiation and impairs the tumorigenic potential of human glioblastoma-initiating cells. Neuropharmacology, 2008, 55:568-576. (I.F. 3.801)
92. Musante V., Neri E., Feligioni M., Puliti A.M., Pedrazzi M., Conti V., Usai C., Diaspro A., Ravazzolo R., Henley J.M., Battaglia G., Pittaluga A. Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings. Neuropharmacology, 2008, 55:474-482. (I.F. 3.801)
93. Mastroiacovo F., Busceti C.L., Biagioni F., Moyanova S.G., Meisler M.H., Battaglia G., Caricasole A., Bruno V., Nicoletti F. Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia. J. Cereb. Blood. Flow. Metab., 2009, 29:264-272. (I.F. 5.147)
94. Seeman P., Battaglia G., Corti C., Corsi M., Bruno V. Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2High receptors and marked supersensitivity to the dopamine agonist (+)PHNO. Synapse, 2009, 63:247-251. (I.F. 2.524)
95. Rampello L., Battaglia G., Rampello L., Malaguarnera M. Bilateral benign blepharoclonus. Clin. Neurol. Neurosur., 2009, 111:480-481. (I.F. 1.553)
96. Iacovelli L., Molinaro G., Battaglia G., Motolese M., Di Menna L., Alfiero M., Blahos J., Matrisciano F., Corsi M., Corti C., Bruno V., De Blasi A., Nicoletti F. Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: mGlu2 receptors are resistant to homologous desensitization. Mol. Pharmacol., 2009, 75:991-1003. (I.F.4.002)
97. Molinaro G., Battaglia G., Riozzi B., Di Menna L., Rampello L., Bruno V., Nicoletti F. Memantine treatment reduces the expression of the K+/Cl- cotransporter KCC2 in the hippocampus and cerebral cortex, and attenuates behavioural responses mediated by GABAA receptor activation in mice. Brain Res., 2009, 1265:75-79. (I.F.2.212)
98. Molinaro G., Traficante A., Riozzi B., Di Menna L., Curto M., Pallottino S., Nicoletti F., Bruno V., Battaglia G. Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-HT2A serotonin receptors in the frontal cortex of living mice. Mol. Pharmacol., 2009, 76:379-387. (I.F.4.002)
99. Battaglia G., Molinaro G., Riozzi B., Storto M., Spinsanti P., De Vita T., Mudò G., Corti C., Corsi M., Nicoletti F., Bruno V., Belluardo N. Activation of mGlu3 metabotropic glutamate receptors enhances the production of glial-cell-line-derived neurotrophic factor. Plos One, 2009, 4(8):e6591. (I.F. 4.351)
100. Piccinin S., Cinque C., Calò L., Molinaro G., Battaglia G., Maggi L., Nicoletti F., Melchiorri D., Eusebi F., Massey P., Bashir I.Z. Interaction between ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus. J. Neurosci., 2010, 30(8):2835-2843. (I.F. 7.5)
101. Musante V., Summa M., Neri E., Puliti A., Godowicz TT., Severi P., Battaglia G., Raiteri M., Pittaluga A. The HIV-1 viral protein Tat increases glutamate and decreases GABA exocytosis from human and mouse neocortical nerve endings. Cereb. Cortex, 2010, 20:1974-1984. (I.F. 6.519)
102. Chiechio S., Copani A., Zammataro M., Battaglia G., Gereau IV W.R., Nicoletti F. Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain. Trends Pharmacol., 2010, 31(4):153-60. (I.F. 9.6)
103. Molinaro G., Pietracupa S., Di Menna L., Pescatori L., Usiello A., Battaglia G., Nicoletti F., Bruno V. D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices. Neurosci. Lett., 2010, 478(3):128-130. (I.F. 2.2).
104. Fallarino F., Volpi C., Fazio F., Notartomaso S., Vacca C., Busceti C.L., Bicciato S., Battaglia G., Bruno V., Puccetti P., Fioretti C.M., Nicoletti F., Grohmann U., Di Marco R. Metabotropic glutamate receptor 4 impacts adaptive immunity restraining neuroinflammation. Nat. Med., 2010, 16(8):897-902. (I.F. 27.136).
105. Bruno V., Battaglia G., Nicoletti F. The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases. Neurol. Sci., 2011 Jan;31 Suppl 3:283-8. (I.F. 1.12).
106. Moyanova S., Mastroiacovo F., Kortenska L., Mitreva R., Fardone E., Santolini I., Sobrado M., Battaglia G., Bruno V., Nicoletti F., Ngomba T.R. Protective role for type-4 metabotropic glutamate receptors against ischemic brain damage. J. Cereb. Blood. Flow. Metab., 2011, 31(4):1107-18. (I.F. 5.147)
107. Caraci F., Molinaro G., Battaglia G., Giuffrida M.L., Riozzi B., Traficante A., Bruno V., Cannella M., Merlo S., Drago F., Sortino M.A., Copani A., Nicoletti F. Targeting group-II metabotropic glutamate receptors for the treatment of psychosis associated with Alzheimer’s disease: dual activation of mGlu2 and mGlu3 receptors is neuroprotective, whereas selective activation of mGlu2 receptors amplifies β-amyloid toxicity. Mol. Pharm., 2011, 79(3):618-626. (I.F.4.002)
108. Battaglia G., Cannella M., Riozzi B., Orobello S., Maat-Schieman M.L., Aronica E., Busceti C.L., Ciarmiello A., Sassone J., Ciammola A., Pouladi M.A., Hayden M.R., Sipione S., Bruno V., Nicoletti F., Squitieri F. Early defect of transforming growth factor β-1 formation in Huntington’s disease. J. Cell. Mol. Med., 2011, 15(3):555-571. (I.F. 5.1)
109. Matrisciano F., Busceti C.L., Bucci D., Orlando R.M., Caruso A., Molinaro G., Cappuccio I., Riozzi B., Gradini R., Caraci F., Copani A., Scaccianoce S., Melchiorri D., Bruno V., Battaglia G., Nicoletti F. Induction of the Wnt antagonist, dickkopf-1, is required for stress-induced hippocampal damage in mice. PlosOne 2011, 6(1):e16447. (I.F. 4.351)
110. D’Antoni S., Berretta A., Seminara G., Longone P., Giuffrida-Stella A.M., Battaglia G., Sortino M.A., Nicoletti F., Catania M.V. Pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death. Neurobiol. Dis., 2011, 42(3):252-264. (I.F. 4.518)
111. Ngomba R.T., Santolini I., Biagioni F., Molinaro G., Simonyi A., van Rijn C.M., D’Amore V., Mastroiacovo F., Olivieri G., Gradini R., Ferraguti F., Battaglia G., Bruno V., Puliti A., van Luijtelaar G., Nicoletti F. Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 2011, 60(7-8):1281-1291. (I.F. 3.801)
112. Caraci F., Battaglia G., Bruno V., Bosco P., Carbonaro V., Giuffrida M.L., Drago F., Sortino M.A, Nicoletti F., Copani A. TGF-β1 pathway as a new target for neuroprotection in Alzheimer’s disease. CNS Neuroscience & Therapeutics, 2011, 17:237-249. (I.F. 4.432)
113. Ngomba R.T., Santolini I., Salt T., Ferraguti F., Battaglia G., Nicoletti F., Van Lujtelaar G. Metabotropic glutamate receptors as potential targets for the treatment of absence epilepsy. Epilepsy, 2011, 52(7):1211-1222. (I.F. 4.015).
114. Pérez-Silanes S., Berrade L., Aisa B., Ramirez M., Galiano S., Guccione S., Moltzau L., Levy F., Nicoletti F., Battaglia G., Molinaro G., Aldana I., Monge A. Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. J. Med. Chem., 2011, 54(8):3086-3090. (I.F. 4.895).
115. Rampello L., Casolla B., Rampello L., Pignatelli M., Battaglia G., Gradini R., Orzi F., Nicoletti F. The conditioned eyeblink reflex: a potential tool for the detection of cerebellar dysfunction in multiple sclerosis. Mult. Scler., 2011, 17(10):1155-61. (I.F. 3.279).
116. Spampinato S.F., Molinaro G., Merlo S., Iacovelli L., Caraci F., Battaglia G., Nicoletti F., Bruno V., Sortino M.A. Estrogen receptors and type-1 metabotropic glutamate receptors are interdependent in protecting cortical neurons agains β-amyloid toxicity. Mol. Pharmacol., 2012, 81(1):12-20. (I.F.4.002).
117. Fazio F., Lionetto L., Molinaro G., Bertrand H.O., Acher F., Ngomba R.T., Notartomaso S., Curini M., Rosati O., Scarselli P., Di Marco R., Battaglia G., Bruno V., Simmaco M., Pin J.P, Nicoletti F., Goudet C. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors. Mol. Pharmacol., 2012 May;81(5):643-56. (I.F.4.725).
118. Panaccione I., King R., Molinaro G., Riozzi B., Battaglia G., Nicoletti F., Bashir I.Z. Constitutively active PKMzeta: an essential regulator of synaptic transmission in developing cerebral cortex. Neuropharmacology 2012, In press. (I.F. 4.677).
119. Caraci F., Spampinato S., Sortino M.A., Bosco P., Battaglia G., Bruno V., Drago F., Nicoletti F., Copani A. Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection. Cell Tissue Res. 2012 Jan;347(1):291-301. (I.F. 2.804).
120. Caraci F., Battaglia G., Sortino M.A., Spampinato S., Molinaro G., Copani A., Nicoletti F., Bruno V. Metabotropic Glutamate Receptors in neurodegeneration/neuroprotection: still a hot topic? Neurochem. Int. 2012, 61(4):559-565. (I.F. 3.601).
121. Amalric M., Lopez S., Goudet C., Fisone G., Battaglia G., Nicoletti F., Pin J.-P., Acher F.C. Group III metabotropic glutamate receptor agonists: discovery and pathophysiological applications in Parkinson’s disease. Neuropharmacology, 2012, In press. (I.F. 4.677).
122. Pignatelli M., Vollmayr B., Richter S.H., Middei S., Matrisciano F., Molinaro G., Nasca C., Battaglia G., Ammassari-Teule M., Nisticò R., Nicoletti F., Gass P. Enhanced mGlu5-receptor dependent long-term depression at the schaffer collateral-ca1 synapse of congenitally learned helpless rats. Neuropharmacology, 2012, In press. (I.F. 4.677).
123. Nasca C., Orlando R., Marchiafava M., Boldrini P., Battaglia G., S. Scaccianoce, Matrisciano F., Pittaluga A., Nicoletti F. Exposure to predator odor and resultant anxiety enhances the expression of the α2δ subunit of voltage-sensitive calcium channels in the amygdala. J. Neurochem., 2012, In press. (I.F. 4.061).
124. Busceti C.L., Bucci D., Molinaro G., Paola Di Pietro, Zangrandi L., Gradini R., Rosario Moratalla, Battaglia G., Bruno V., Nicoletti F., Fornai F. Lack or inhibition of dopaminergic stimulation induces a developmental increase of striatal tyrosine hydroxylase-positive interneurons. PlosOne, 2012, 7(9): e44025. (I.F. 4.351)
125. Pieretti S., Mastriota M., Tucci P., Battaglia G., Trabace L., Nicoletti F., Scaccianoce S. Brain nerve growth factor unbalance induced by anabolic androgenic steroids in rat. Med. Sci. Sports Exer., 2012, In Press. (I.F. 4.431)
126. Rampello L, Malaguarnera M, Rampello L, Nicoletti G, Battaglia G. Stabbing headache in patients with autoimmune disorders. Clin Neurol Neurosurg., 2012, 114(6):751-3. (I.F. 1.553)
127. Ciceroni C., Bonelli M., Mastrantoni E., Niccolini C., Laurenza M., Traficante A., Spinsanti P., Ricci-Vitiani L., Arcella A., De Maria R., Nicoletti F., Battaglia G.*, Melchiorri D*. Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas. Cell Death Diff., 2012, In press. *co-last author. (I.F. 8.849)
128. Bernabucci M., Notartomaso S., Zappulla C., Fazio F., Cannella M., Motolese M., Battaglia G., Bruno V., Gradini R., Nicoletti F. N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors. Mol. Pain, 2012, 8(1):77. (I.F. 3.526)
129. Spampinato S.F., Merlo S., Molinaro G., Battaglia G., Bruno V., Nicoletti F., Sortino M.A. Dual effect of estrogen on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor. Endocrinology, 2012, 153(12):5940-8. (I.F. 4.459)
130. Di Menna L., Molinaro G., Di Nuzzo L., Zappulla C., Pozzilli C., Turrini R., Battaglia G., Nicoletti F., Bruno V. Activation of type-1 sphingosine-1-phosphate receptors is protective against excitotoxiC neuronal death in culture. Pharmacol. Res., 2012, 67(1):1-9. (I.F. 4.436)
131. Romanelli P., Battaglia G., Bräuer-Krisch E., Prezado Y., Requardt H., Anschel D.J., Le Duc G., Fardone E., Bravin A. Synchrotron-generated microbeam sensorimotor cortex transections induce seizure control without disruption of neurological functions. PlosOne, 2012, In press. (I.F. 4.351)
132. Nasca C., Xenos D., Barone Y., Caruso A., Scaccianoce S., Matrisciano F., Battaglia G., Mathé A., Pittaluga A., Nicoletti F. The acetylating drug, l-acetylcarnitine, induces a rapid and long-lasting antidepressant effect involving the induction of type-2 metabotropic glutamate receptors. 2012, Submitted.
133. Macaluso A., Bernabucci M., Trabucco A., Ciolli L., Troisi F., Baldini R., Gradini R., Battaglia G., Nicoletti F., Collini S. Analgesic effect of a single preoperative dose of the antibiotic, ceftriaxone, in humans. 2012, Submitted.
134. Cartelli D., Casagrande F., Busceti C., Bucci D., Molinaro G., Traficante A., Passarella D., Giavini E., Battaglia G., Cappelletti G. Microtubules are early altered in mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and treatment with the microtubule stabilizer epothilone d is neuroprotective. 2012, Submitted.
135. Nicoletti F., Battaglia G., Caraci F., Sortino M.A., Drago F., Copani A., Nasca C., Rampello L., Bruno V. Subtype-selective ligands of metabotropic glutamate receptors: potential disease-modifying drugs in the treatment of Parkinson’s disease and Alzheimer’s disease? 2012, Submitted.
CAPITOLI DI LIBRI IN LINGUA INGLESE
1. Nicoletti F., Aronica E., Battaglia G., Bruno V., Casabona G., Catania M.V., Copani A., Genazzani A.A., L’Episcopo M.R., Condorelli D.F. Plasticity of metabotropic glutamate receptors in physiological and pathological conditions. In: Metabotropic glutamate receptors (P.J. Conn and Patel Eds.) Humana Press, 1994, pp 243-269. (ISBN: 0896032914)
2. Nicoletti F., Battaglia G., Bruno V., Casabona G., Copani A., Musco S. Metabotropic glutamate receptors and cerebaral cortex. In: Excitatory Amino Acids and the Cerebral Cortex. (F. Conti and T. P. Hicks Eds.) The MIT Press, London, 1996, pp 73-78. (ISBN: 0262032384)
3. Bruno V., Copani A., Battaglia G., Casabona G., Nicoletti F. Metabotropic glutamate receptors as a drug target in brain ischemia. In: Primer in Cerebrovascular Diseases. (Welch K. M. A., Caplan R. L., Reis J. D., Siesjö K. B. and Weir B. Eds.) Academic Press, New York, 1996, pp. 199-200 (ISBN: 0127431705)
4. Battaglia G., Perry W.K., Monn A.J., Schoepp D.D. Inhibition of glutamate and aspartate release in vivo by (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate, a selective agonist of group II metabotropic glutamate receptors. In: Metabotropic glutamate receptors and brain function, (Moroni F., Nicoletti F. and Pellegrini-Giampietro D. E., Eds.), Portland Press Proceedings, London, 1998, pp 235-241. (ISBN: 1855781174)
5. Flor J.P., Battaglia G., Nicoletti F., Gasparini F., Bruno V. Neuroprotective activity of metabotropic glutamate receptor ligands. In: Molecular and Cellular Biology of Neuroprotection in the CNS. Edited by C. Alzheimer, Kiel, Germany, 2002. (ISBN: 158706104X)
6. Bruno V., Battaglia G., Nicoletti F. Metabotropic glutamate receptors and neurodegeneration. In: Excitotoxicity in neurological diseases, new therapeutic challange. Edited by Carlo Ferrarese and M. Flint Beal, Kluwer Academic Publishers, Norwell, USA, 2004. (ISBN: 1402076800).
7. Nicoletti F., Battaglia G., Bruno V. Metabotropic glutamate receptors: molecular biology, pharmacology and cell biology. In: Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2008. (ISBN: 0080450466).